Vishal Pande

By Ajinkya Pote, Vikas Ahirrao and Vishal Pande

In case cancers are located deep inside the body and are very tough to diagnose, diagnostic tools like MRI/CT scans can be employed to detect these cancers. The major challenge in such cases is the delivery of MRI active agents or visualizing agents to the target site. In this context we will discuss different mesoporous nanoparticles that can be employed to target the tissue at a specific location, its functionalization to reach the target site (Folic acid), different simple dyes as well as specific dyes which offer theranostic functionality. The nanoparticles like mesoporous silica nanoparticles offer the possibility to load therapeutic and diagnostic agents. Its surface allow multiple functionalization and conjugations which offer target specific delivery of these agents. Moreover we will also overview different modern drug delivery inventions for offering theranostic application.

Part of the book: Advanced Drug Delivery Systems

By Sachin Kothawade, Vaibhav Wagh, Vishal Pande and Amit Lunkad

The search for a cure for human immunodeficiency virus (HIV) infection has been a persistent challenge in global health. While antiretroviral therapy (ART) has significantly improved the prognosis for individuals living with HIV, the need for lifelong treatment and the presence of viral reservoirs and drug resistance necessitate innovative approaches. Gene therapy has emerged as a promising avenue in HIV treatment, utilizing genetic modification to address the complexities of the virus. This chapter provides a comprehensive overview of gene therapy approaches in HIV treatment. It explores the fundamental principles and techniques of gene therapy and highlights the specific challenges posed by HIV. Various gene therapy strategies, including gene editing technologies and gene transfer methods, are discussed in detail, along with their potential advantages and limitations. Safety, efficacy, and ethical considerations in gene therapy for HIV are also examined. The chapter concludes with a glimpse into the future of gene therapy in HIV treatment, emphasizing the importance of interdisciplinary collaboration and continued research. This chapter aims to inspire further exploration and harnessing of gene therapy’s transformative potential in the quest for an HIV cure.

Part of the book: HIV Treatment

By Sachin Kothawade, Vishal Pande, Vaibhav Wagh, Kalyani Autade, Sandesh Bole, Rajashri Sumbe and Shubhangi Albhar

This chapter presents an overview of the perspective chapter on pharmaceutical drying within the context of drug manufacturing. It explores the significance of pharmaceutical drying in ensuring the stability and efficacy of drug products. The chapter begins by defining pharmaceutical drying and emphasizing its importance in the manufacturing process. Various methods of pharmaceutical drying, including air drying, vacuum drying, freeze-drying, and spray drying, are discussed, and a comparison between these methods is provided. Factors that influence pharmaceutical drying, such as physical and chemical properties of the product, drying temperature, drying time, pressure, humidity, and solvent properties, are examined. The chapter also highlights the challenges associated with pharmaceutical drying, including product stability and degradation, loss of potency, residual solvents, and the formation of amorphous or crystalline solids. Strategies to overcome these challenges, such as process optimization, the use of drying aids, control of drying parameters, and formulation considerations, are explored. Quality control measures in pharmaceutical drying, including the monitoring of residual moisture and solvent levels, characterization of dried products, and adherence to regulatory guidelines, are discussed.

Part of the book: Drying Science and Technology