**3. Materials & methods**

#### Population

We enrolled a sample of 302 subjects (225 men and 77 women) presenting consecutively at the Unit of Pneumology of the Luigi Sacco Hospital of Milan, for a full cardiopulmonary monitoring during sleep.

#### *Methods*


Patients were asked to give written yes/no responses to written questions as follows: (1) Has the patient experienced abnormal scalp sensitivity or discomfort during headache attacks? If yes, does this abnormal sensitivity or discomfort arise from (a) touching head skin; (b) touching hair; (c) combing hair; (d) brushing hair; (e) wearing glasses; (f) using a hair-band, curlers or elastic for forming a ponytail; (g) lying with head resting on the pain side? Patients replying yes to the first question and at least to one of questions (a-f) were considered to have headache-associated allodynia



## *Statistics*

88 Sleep Disorders

Based on the above reported background, we designed a study to investigate the possible relationships between nocturnal breathing disturbances and headache, particularly






We enrolled a sample of 302 subjects (225 men and 77 women) presenting consecutively at the Unit of Pneumology of the Luigi Sacco Hospital of Milan, for a full cardiopulmonary



Patients were asked to give written yes/no responses to written questions as follows: (1) Has the patient experienced abnormal scalp sensitivity or discomfort during headache attacks? If yes, does this abnormal sensitivity or discomfort arise from (a) touching head skin; (b) touching hair; (c) combing hair; (d) brushing hair; (e) wearing glasses; (f) using a hair-band, curlers or elastic for forming a ponytail; (g) lying with head resting on the pain side? Patients replying yes to the first question and at least to

one of questions (a-f) were considered to have headache-associated allodynia - Sleep behavior was evaluated through semi-structured ad hoc questionnaire exploring the mean latency of sleep onset (more or less of 30 min), the frequency of nights with nocturnal wake-up (<2 or >3 nights/month) and the subjective perception of sleep

**2. Objective** 

migraine, with and without allodynia.

The aims of the study were:

(AHI, SpO2, T<90%).

these groups and

quality during sleep.

**3. Materials & methods** 

monitoring during sleep.

Population

*Methods* 

patients, grouped by different diagnostic types.

clinically made according to the ICHD-II criteria.

quality (satisfied/not-satisfied).

combing hair, brushing hair, wearing glasses, and so on.

problems;

Student T test with Bonferroni correction was used to compare mean ages, mean AHI, mean T<90% and mean SpO2, between groups (subjects with or without headache, with or without allodynia).

Chi square test was applied to compare the distribution of different sleep behavior aspects between different diagnostic groups.
