**4. Conclusions**

3DOM-MBGCs were synthesized successfully by the sol–gel method using spherical PMMA colloidal crystals of 300 nm and non-ionic block copolymer P123 as cotamplates. The morphology of S53P4 bioactive glass revealed wellordered macroporous structure with larger surface area. While, 45S5 bioactive glass had shown distorted 3DOM structure with a bit higher pore diameter. Base on the SEM and FTIR results indicated the better bioactivity of 45S5 than S53P4 bioactive glass ceramics which was able to initiate the formation of hydroxyapatite-like layer on glass surface after soaking in SBF solution within 2 days (45S5) and 3 days (S53P4). The drug delivery system based on 45S5 and S53P4 3DOM-MBGCs have been synthesized, and the release behavior of both porous bioactive glasses were studied. The results indicated that the S53P4 glasses showed higher drug loading efficiency and gave relatively initial fast release compared to the 45S5 due to its high surface area. Even though, the drug loading content was not significant different from that of both bioactive glass ceramics. The resultant drug release mechanism was occupied from the first 60% of gentamicin release profile fitted to the Peppas-Korsmeyer model, which clarified that the kinetics of drug release from the bioactive glass ceramics mostly occurred by Fickian diffusion mechanism.

Therefore, the results indicated the bioactivity and drug release profile of mesoporous bioactive glass ceramics which can accelerate the bone growth or new bone formation and could be a use as a promising drug release system for bone implant materials preparation.

*Three-Dimensionally Ordered Macroporous-Mesoporous Bioactive Glass Ceramics for Drug… DOI: http://dx.doi.org/10.5772/intechopen.95290*
