*3.1.1 45S5 Bioglass*

Ceramic 45S5 bioglass with 24.5% sodium oxide, 45% silicon dioxides, 24.5% calcium dioxide and 6% phosphorus pentoxide, shown on **Figure 11**, have attracted the attentions of researchers as a biomaterial substance because of its osseointegration capability, bioactive surface and the ability of healing bone damages [90–92]. It can be prepared by melt-cast method with various crystallinity including amorphous and crystalline [93]. But, to guarantee the perfect amorphous sample crystallization, the heat-treatment should be continued for 1 hour at 1000 °C.
