**Acknowledgements**

This research was supported by the NIH MIRA R35GM133795 and NSF CAREER CBET-1943302 (P. Chen). Additionally, this material is based upon work supported ALS while serving at the National Science Foundation. Any opinion, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

### **Conflict of interest**

The authors declare no conflict of interest.
