**5. Conclusion**

This chapter provides a detailed description of the surface plasmon resonance phenomenon with the recent trends that are being applied in the advancement of SPR based sensors where the application of hybrid structures as well as bimetallic configurations are found to be potential techniques to enhance the sensor performances. Besides, it demonstrates different 2D materials applied for sensing capability enhancement of the hybrid SPR biosensors. Also, two 5 layer prism based hybrid heterostructures (Prism-Au-PtSe2-WS2 and Prism-Ag-PtSe2-WS2) have been comprehensively discussed here to show the effectiveness of hybrid technology.
