**8. Conclusion**

Psoriasis is a disease treated near exclusively from dermatologists. Nevertheless some factors indicate the need for a new attention by the head and neck area specialists, especially by the otorhinolaringologists and maxillofacial surgeons.

Recent literature focuses on relationship between autoimmunity and infection, the latter representing the prince environmental factor that could play a critical role in the pathogenesis of autoimmune diseases in susceptible individuals with the production of cross-reacting antibodies and the induction of the inflammatory second hit. When infectious agents are not recognized as alien and not completely eliminated, pathogen expansion could be promoted by molecular similarity of microbial and host antigens.

As above mentioned important relationship has been demonstrated between tonsillar T cells and skin lesion in PPP patients with immune response to α-streptococci.

Further investigations with translation from bench research to clinical knowledge and vice versa and with interrelation between dermatologists and head and neck specialists could result in considerable progress in understanding immunopathogenesis of Psoriasis and other immuno-mediated diseases.
