**Meet the editor**

Dr. Jennifer Soung is a board certified dermatologist and Assistant Clinical Professor of Dermatology at the University of California, Irvine. As the director of Dermatology Clinical Research at UC Irvine, Dr. Soung has a broad interest in medical and cosmetic dermatology as well as clinical research. Her clinical and research interest is the treatment of psoriasis. She is currently the

Principal Investigator of two large clinical trials focused on examining new medications for the treatment of psoriasis. Besides psoriasis, Dr. Soung plans to explore new treatment options in rosacea and discoid lupus. Dr. Soung treats adult and pediatric skin conditions, including acne, eczema, rosacea, and skin cancer. She is well-versed in techniques for cosmetic rejuvenation of the aging face including Botox, lasers and chemical peels. Dr. Soung received her Bachelor of Arts at Brown University and earned a medical degree from the Albert Einstein College of Medicine. She completed a medical internship at the West Los Angeles-UCLA Veterans Hospital and a dermatology residency at the University of California, Irvine. Dr. Soung also pursued advanced fellowship training in dermatopharmacology at the Mount Sinai Medical Center, NY and earned top honors for her research on pharmacogenetics.

Contents

**Preface IX** 

**Part 1 Pathophysiology 1** 

Chapter 4 **Psoriatic Skin Models:** 

Peter Härle

**Part 2 Clinical Presentation 63** 

Chapter 6 **Head and Neck Psoriasis 79** 

Chapter 7 **Metabolic Features in Psoriasis 107**  Giulia Ganzetti, Anna Campanati, Giulia Liberati and Annamaria Offidani

Chapter 8 **UVB and Vitamin D in Psoriasis 121** 

A. Osmancevic

Chapter 1 **Psoriasis and Stem Cells 3** 

Kaiming Zhang, Guohua Yin, Xinhua Li,

Anna Balato, Nicola Balato, Matteo Megna, Maria Schiattarella, Serena Lembo and Fabio Ayala

Chapter 2 **Pathogenesis of Psoriasis: The Role of** 

Xuping Niu, Ruixia Hou, Ruifeng Liu and Junqin Li

Chapter 3 **Wound Repair Studies Reveal New Insights to Psoriasis 29**  Chee Ren Ivan Lam, Ming Jie Tan, Yan Yih Goh, Mark Boon Yang Tang and Nguan Soon Tan

**A Need for the Pharmaceutical Industry 47** 

Chapter 5 **Detecting Psoriasis Arthritis Early in the Disease Course – Why This is Important and How Dermatologists and Rheumatologists Can Successfully Cooperate? 65** 

> Sebastiano Bucolo, Valerio Torre, Giuseppe Romano, Carmelo Quattrocchi, Maura Filidoro and Claudio Caldarelli

Jessica Jean, Martha Estrella Garcia-Pérez and Roxane Pouliot

**Pro-Inflammatory Cytokines Produced by Keratinocytes 9** 
