**Abstract**

The condition of Critically ill patients in the Intensive Care Unit (ICU) can make heavier impairment physical and cognitive functions. The research objective is to prove that physical-cognitive therapy affects towards increasing physical and cognitive functions to Critically ill patients in ICU. The research design was a Randomized Controlled Trials (RCTs). The samples were Critically ill patients in the ICU of Kediri Baptist Hospital as many as 64 Critically ill patients according to inclusion and exclusion criteria. The research has got ethical clearance from the Committee Ethics Medical Faculty of Diponegoro University. The research instrument used Physical Function ICU Test (PFIT) Indonesian Version and Mini-Mental State Examination (MMSE) Indonesian Version. The differential test used Independent t-test on physical function and Mann-Whitney test on cognitive function towards the intervention group and control group. The results showed that physical-cognitive therapy significantly affected increasing physical function (P < 0.001) with a mean increase of 3.2 points and cognitive function (P < 0.001) with a mean increase of 7.3 points. The difference test of influence between the intervention group and the control group was done by testing the posttest data on physical function (P < 0.001) and cognitive function (P < 0.001) in both groups. Effect size >0.8 (Physical Function: 3.2; Cognitive Function: 1.9). In conclusion, there was affecting physical-cognitive therapy towards increasing physical and cognitive functions to Critically ill patients in ICU.

**Keywords:** critically ill patient, intensive care unit, physical-cognitive therapy, physical function, mental stage
