**4.1 Antimicrobial agents**

*Drug Design - Novel Advances in the Omics Field and Applications*

were docked into a similar binding site. Docking study demonstrated a solid hydrophobicity between amino acids, such as Arganine (ARG141), Glutamine (GLU146), with hydrogen of aldehyde at 2.279. The amino acids included are Glycine GLY176A, Aspartine ASP175A, Threonine THR147B Lysine LYS227A, Phenyl alanine PHE58A and Arganine ARG141B which may be assuming a significant role in the specific

*Representative interactions shown by K20 with amino acid residues of CYP51A1, P45014DM [48].*

In this investigation, researchers scanned for new secondary metabolites from ocean inferred growth strain FKJ-0025 and found two new compounds, sarcopodinols A (1) and B (2), together with a known compound, SF-227. This is the principal report of secondary metabolites separated from family Sarcopodium*.* Cytotoxicity test utilizing human tumor cell lines, 1 demonstrated cytotoxicity against Jurkat cells. Eminently, 2 demonstrated cytotoxicity against HL-60, Jurkat, and Panc1 cells. These outcomes recommend that the absence of 5′-OH is the significant factor behind the lethality against HL-60 and Panc1 cells [49]. The novel Anthraquinone, 2-(dimethoxymethyl)- 1-hydroxyanthracene-9,10-dione, jointly with nine studied compounds (2–10), were taken from a marine derived fungi *A. versicolor*. 1 showed solid inhibitory activity against MRSA ATCC 43300 and MRSA CGMCC 12409 (with MIC estimations of 3.9 and 7.8 μg/mL separately) and moderate activity against analyzed strains of Vibrio. Molecular docking studies with

binding of compounds with target [48] (**Figure 7**).

**4. Recent discoveries**

**Figure 7.**

**124**

Antifungal peptides created by certain lactic acid bacteria strains have high potential for applications in expansive scope of nourishments. The component of peptides antifungal movement is identified with their properties, for example, low atomic weight, secondary structure, concentrations. The antifungal peptides were proposed to be utilized as bio-additives to decrease as well as supplant chemical preservatives [51]. White rot fungi that go under the division eumycota are heterogeneous gathering of fungi having ability to degrade a wide assortment of difficult compounds. Xenobiotic degradation may be due to non-specific enzymes. Manganese peroxidase, laccase, lignin peroxidase were explored seriously for the wide scope of xenobiotics. These organisms are having the ability to separate the lignin in wood without degrading cellulose, sometimes both cellulose and lignin will be degraded [52]. Nanotechnology for the creation of nanoparticles utilizing fungal cells is an ongoing phenomenon. Parasite like *Colletotrichum sp., A. clavatus, and Pestalotia sp.* have been utilized for improvement of nanoparticles against pathogenic microorganisms [33].
