**4. Recent discoveries**

In this investigation, researchers scanned for new secondary metabolites from ocean inferred growth strain FKJ-0025 and found two new compounds, sarcopodinols A (1) and B (2), together with a known compound, SF-227. This is the principal report of secondary metabolites separated from family Sarcopodium*.* Cytotoxicity test utilizing human tumor cell lines, 1 demonstrated cytotoxicity against Jurkat cells. Eminently, 2 demonstrated cytotoxicity against HL-60, Jurkat, and Panc1 cells. These outcomes recommend that the absence of 5′-OH is the significant factor behind the lethality against HL-60 and Panc1 cells [49]. The novel Anthraquinone, 2-(dimethoxymethyl)- 1-hydroxyanthracene-9,10-dione, jointly with nine studied compounds (2–10), were taken from a marine derived fungi *A. versicolor*. 1 showed solid inhibitory activity against MRSA ATCC 43300 and MRSA CGMCC 12409 (with MIC estimations of 3.9 and 7.8 μg/mL separately) and moderate activity against analyzed strains of Vibrio. Molecular docking studies with

**125**

*Natural Medicinal Compounds from Marine Fungi towards Drug Discovery: A Review*

expanding consideration as a source of antibacterial factor [50].

AmpC β-lactamase IV and topoisomerase indicated least binding interactions and supported antimicrobial movement of this compound is a novel compound merited

Antifungal peptides created by certain lactic acid bacteria strains have high potential for applications in expansive scope of nourishments. The component of peptides antifungal movement is identified with their properties, for example, low atomic weight, secondary structure, concentrations. The antifungal peptides were proposed to be utilized as bio-additives to decrease as well as supplant chemical preservatives [51]. White rot fungi that go under the division eumycota are heterogeneous gathering of fungi having ability to degrade a wide assortment of difficult compounds. Xenobiotic degradation may be due to non-specific enzymes. Manganese peroxidase, laccase, lignin peroxidase were explored seriously for the wide scope of xenobiotics. These organisms are having the ability to separate the lignin in wood without degrading cellulose, sometimes both cellulose and lignin will be degraded [52]. Nanotechnology for the creation of nanoparticles utilizing fungal cells is an ongoing phenomenon. Parasite like *Colletotrichum sp., A. clavatus, and Pestalotia sp.* have been utilized for improvement of nanoparticles against

Bioinformatics has built up itself as a basic apparatus in target revelation. In silico pharmacology paradigm is progressing and presents a rich exhibit of chances that will help with expediating the revelation of new targets, and leads to discovery of compounds with biological activities. The drug design is based on analysis of structure of fungal species complexes. Various evaluations are found using quasi in vivo assay and pharmacokinetic analysis. For example, X-ray structures of *C. albicans* CYP51 complexes with posaconazole and VT-1161, providing a molecular mechanism for the potencies of these drugs against pathogens that are intrinsically

Comparative structural analysis indicates the phylum-specific CYP51 features highlights that could coordinate future rational improvement of more productive expansive range antifungals. Basic assay normally focused on antimicrobial and antifungal activity. Viable and safe medications in the field on infections and malignant growth are unquestionably required. Subsequently, it is recommended to widen biological screens for the once in a while examined biological activities,

which might be significant for the treatment of ceaseless illnesses.

*DOI: http://dx.doi.org/10.5772/intechopen.94137*

**4.1 Antimicrobial agents**

pathogenic microorganisms [33].

**5. Conclusion**

resistant to fluconazole.

**Future perspectives**

AmpC β-lactamase IV and topoisomerase indicated least binding interactions and supported antimicrobial movement of this compound is a novel compound merited expanding consideration as a source of antibacterial factor [50].
