**9.2 BRAF & BRAF/MEK inhibitors**

BRAF is a proto-oncogene, that its protein product is a serine/threonine-protein kinase B-Raf that make conform the MAP kinase/ERKs signaling pathway, which works during cell division and differentiation [69]. In patients with MM, the incidence of BRAF V600E mutations is about 7–12% [70]. Trials evaluating BRAF and BRAF/MEK inhibitors in patients with MM harboring BRAF mutations are still undergoing [71].
