**2. Diagnosis**

Clinical investigation of MM requires the evaluation of bone marrow for plasma cell infıltration, and detection and quantification of monoclonal protein in the serum or urine, and evidence for end-organ damage (i.e., hypercalcemia, renal insuffıciency, anemia, or bone lesions) [11, 12]. This can be done by grouping the different diagnostic and prognostic factors measurable parameters, such as protein analysis, morphology, immunophenotyping, genetics and cytogenetics, and imaging techniques (i.e., MRI, PET/CT) [11].
