**5. The randomized open-label, phase III international BOSTON trial in patients with relapsed or refractory multiple myeloma with a median of two prior therapies**

The combination of selinexor and bortezomib once per week plus dexamethasone twice per week (SVd) was compared with bortezomib twice per week in combination with dexamethasone four times per week for the first six months and one half of this dose thereafter (Vd) [30]. Median PFS was longer with selinexor treatment: 13.93 months versus 9.46 months in the Vd group. The improvements in survival and response rates with selinexor were associated with higher rates of adverse events [30].

This work was supported by the project for conceptual development of research organisation No 00023736 (Institute of Hematology and Blood Transfusion) from the Ministry of Health of the Czech Republic.
