*2.3.1 Elotuzumab mechanism of action*

SLAMF7 (signaling lymphocytic activation molecule family 7) or CD319 is a cell surface glycoprotein CD2/subset 1 (CS1). SLAMF7 expression is restricted to normal and abnormal plasma cells and NK lymphocytes [49]. Activation of SLAMf7 pathway promotes cell growth and survival. It also plays a critical role in the interaction with the bone marrow microenvironment [49, 50]. Elotuzumab is humanized, first in class IgG1 monoclonal antibody targeting SLAMF7. Elotuzumab primarily activates NK cells promoting antibody-dependent cellular cytotoxicity (ADCC). Elotuzumab has shown no activity when used as a single agent in MM patients.
