**7. Conclusion**

Minimally invasive ablation treatment of locally advanced pancreatic cancer is a promising, yet challenging task. The application of the IRE as a treatment addition to conventional chemotherapy with optional radiotherapy has the potential to increase the overall survival, which needs further investigation upon its efficacy by means of randomized-controlled, multicenter studies. The percutaneous application of IRE demands a sophisticated workflow from preoperative screening of suitable patients to intraoperative implementation of the predefined ablation plan. Computer-assisted surgery systems can aid the clinician during these steps with dedicated software and hardware tools to achieve reproducible and effective treatments.
