**Conflict of interest**

None of the authors received payments or any benefit for participating in this publication. This chapter has not been sponsored neither influenced for any pharmaceutical company, organization, or institution. Authors freely declare any personal potential conflict of interest that could be related or not with this manuscript.

Dr. Christian Caglevic: Honoraria: Andes Biotechnologies. Speaker: MSD, BMS, Lilly. Principal Investigator: MSD, GSK, Bayer, Boehringer Ingelheim, Astellas, Roche, Astra Zeneca, BMS, Novartis. Advisory and Consulting: MSD, BMS, Roche, Boehringer Ingelheim. Sponsored Educational Program (including travel, accommodations, and expenses): BMS, MSD, Roche.

Dr. Mauricio Mahave: no conflicts of interest.

Dr. Cristobal Sanhueza: Expert testimony: Tecnofarma. Travel-accommodations and expenses: Roche, Tecnofarma.

Dr. Luis Ubillos: Advisory and Consulting: Tecnofarma.
