*3.1.3 Oxaliplatin*

Oxaliplatin is a third-generation platinum drug which acts as an alkylating agent in causing DNA damage by intrastrand crosslinks. The drug is not nephrotoxic or ototoxic but the main side effect is cold related dysesthesia which can lead to cumulative sensory neuropathy. It is moderately emetogenic and myelosuppressive. It exhibits synergy with fluoropyrimidines and so is normally used in combination with this class of cytotoxics.
