*7.1.2 Oral dienogest*

Dienogest, a novel 19-nortestosterone derivative, is a synthetic oral progestin that is highly selective for progesterone receptors. Dienogest reduces the painful symptoms in women with endometriosis [18].

A recent study of the oral dienogest for premenopausal menorrhagia and pelvic pains in women with uterine adenomyosis indicated that oral dienogest might be a valuable alternative for treatment of premenopausal pelvic pains in women with uterine adenomyosis [19]. Another pilot study presented the results on the efficacy and safety of dienogest in the treatment of symptomatic adenomyosis. Dienogest significantly reduced adenomyosis-associated pelvic pain as well as serum CA-125 and CA 19-9 levels [20].
