*7.1.4 Other drugs*

Danazol has been the medical therapy for treatment of adenomyosis for several years. Danazol has a direct antiestrogen effect on endometriotic lesions

Nonsteroidal anti-inflammatory drugs (NSAIDs) can relieve mild pain associated with adenomyosis. NSAIDs are the analgesia and anti-inflammatory agents through the pathway of inhibition of PGE2 and COX-2.

Combination oral contraceptives can be used to induce endometrial atrophy and decrease endometrial prostaglandin production to improve dysmenorrhea and menorrhagia.
