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## Meet the editor

Prof. Wojciech Kozubski, MD, PhD is the Head of the Department of Neurology, University of Medical Sciences in Poznan, Poland. He graduated from Medical School in Lodz in 1980. In 1983 he received his PhD and in 2002, his professorship. From 1987 to 1991, he was awarded a scholarship from the Academic Unit of Neuroscience, University of London, Department of Neurology, University of Tel-Aviv and the Department of

Neurology, University of Trondheim. He is an author and co-author of over 300 papers concerning the migraine and related headaches, stroke, and dementia. He is the editor of the handbook of clinical neurology for neurologists, the handbook for medical students, monographs on brain tumours, affective diseases of nervous system and therapy in neurology. From 2011 to 2014, he was the President of the Polish Neurological Society.

Contents

**Section 1**

Horizons

**Section 2**

**Preface XI**

Introduction **1**

**Chapter 1 3**

Advances in Migraine Therapy **9**

**Chapter 2 11**

**Chapter 3 27**

**Chapter 4 41**

The Chronic Face of Migraine - Two Approaches **75**

**Chapter 5 77**

**Chapter 6 109**

Introductory Chapter: Migraine in Post-Triptan Era – New Therapeutic

*by Wojciech Kozubski and Izabela Domitrz*

Recent Advances in Migraine Therapy *by Balaji Ommurugan and Vanishree Rao*

*Giuseppe Sanese and Edoardo Raposio*

*and Dimos D. Mitsikostas*

**Section 3**

Chronic Migraine

Chronic Migraine in Adolescence

*and Luísa Manfredin Vila*

Therapeutic Management: When and What

Minimally Invasive Surgical Treatment of Migraine

*by Francesco Simonacci, Nicolò Bertozzi, Gianluigi Lago, Carlo Fante,* 

*by Theodoros Mavridis, Marianthi Breza, Christina I. Deligianni* 

*by Diana Obelieniene, Ruta Pestininkaite and Daiva Rastenyte*

*by Marcos Antonio da Silva Cristovam, Daniel Albiero Piélak, Júlia Deitos, Júlia Natsumi Hashimoto, Lorena Vaz Meleiro Lopes* 

## Contents


### **Section 4** The New Headache Problem on the Scene **123 Chapter 7 125** Medication Overuse Headache

Preface

A migraine, as described over 6 thousand years ago, is one of the oldest described entities, not only in neurology but in all medicine. It is also one of the most common diseases worldwide, including 11-13% of the Western population. Despite years of research and efforts, the disease still remains a mystery in its aetiology and

Probably, because of that the migraine is still a developing field both in laboratory research and in clinical neurology, involving a number of research workers in many countries. In recent years new hopes and, what is more important, possibilities have come into sight on therapeutic horizons. The monoclonal antibodies developed against the CGRP complex had high prophylactic effectiveness, especially in the

This book covers the most important fields in migraine study and touches on the essential problems of symptomatology, pathophysiology, and therapy of the

The authors of the respective chapters are widely recognized experts in clinical

The special attention was confined to specific problems in 'migrainology' and related fields, as the chronic type of the disease, contemporary modes of migraine treatment, and that seems to be especially important nowadays, as it is still a

The book may serve as invaluable help in the diagnosis and therapy of migraines for all the specialists that might be interested in headache problems, i.e. neurologists,

**Wojciech Kozubski MD, PhD**

Poznań University of Medical Sciences,

Professor,

Poland

neurology, strictly confined to migraine and headache problems.

psychiatrists, internal medicine doctors and many others.

troublesome problem of medical overused headache.

pathophysiology with comparatively modest therapeutic results.

Dear Readers,

chronic type of the disease.

disease.

*by Dhruv Bansal, Pritesh Pranay and Fayyaz Ahmed*
