**6. ICL lesion removal in quiescent G0/G1 phase**

The comprehension of ICL repair is a difficult task because it has an implication on both strands of DNA. The cells in G0/G1 phase do not require homologous recombination for ICL repair [66]. Moreover, all eukaryotic organisms ranging from *Saccharomyces cerevisiae* to the human beings, require NER for the incisions of ICL. The single stranded gap is produced at the first step of NER by the oligonucleotide on ICL lesion. This can be bypassed with the help of translesion DNA polymerases REV1 just like the DNA polymerases (η, ι, κ, and ζ,). Both the DNA polymerases κ, and ζ, as well as REV1 are vital for this stage of NER [67]**.**
