**5. Conclusion**

DNA damage might progressively alter chromatin conformation and, thereby, gene expression types with age. Oxidative damage to nucleic acid is altered in midbrain structures of PD, DLB, and other neurodegenerative disease patients, consequently, inhibiting mitochondrial function. Mitochondrial dysfunction may play a vital role in the pathogenesis of neurodegeneration. What is more, there is a chicken and egg paradox in the studies trying to correlate neuronal degeneration with the signs of DNA damage.
