**Author details**

Jin-Ho Lee1,2 and Michael Hausmann1 \*

1 Kirchhoff-Institute for Physics, Heidelberg University, Heidelberg, Germany

2 Radiation Biology Unit (S-US), Department of Safety and Radiation Protection, FZ Jülich GmbH, Juelich, Germany

\*Address all correspondence to: hausmann@kip.uni-heidelberg.de

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**63**

281-344.

76-67

*Super-Resolution Radiation Biology: From Bio-Dosimetry towards Nano-Studies of DNA Repair…*

[7] Cremer C, Kaufmann R, Gunkel M,

Pres S, Weiland Y, Müller P, Ruckelshausen T, Lemmer P, Geiger F, Degenhard M, Wege C, Lemmermann N, Holtappels R, Strickfaden H, Hausmann M (2011) Superresolution imaging of biological nanostructures by Spectral Precision Distance Microscopy (SPDM). Review.

Biotech. J. 6: 1037-1051

2775-2783

4103-4113

7085-7094

4258-4272

[8] Reid DA, Rothenberg E (2015) Single-molecule fluorescence imaging techniques. Encyclopedia Anal Chem. doi:10.1002/9780470027318.a9494

[9] Thompson RE, Larson DR, Webb WW (2002) Precise nanometer localization analysis for individual fluorescent probes. Biophys J 82:

[10] Hendrix J, Flors C, Dedecker P, Hofkens J, Engelborghs Y (2008) Dark states in monomeric red fluorescent proteins studied by fluorescence correlation and single molecule spectroscopy. Biophysical Journal 94:

[11] Sinnecker D, Voigt P, Hellwig N, Schaefer M (2005) Reversible photobleaching of enhanced green fluorescent proteins. Biochemistry 44:

[12] Betzig E, Patterson GH, Sougrat R, Lindwasser OW, Olenych S, Bonifacino J, Davidson MW, Lippincott-Schwartz J, Hess HF (2006) Imaging intracellular fluorescent proteins at nanometer resolution. Science 313: 1642-1645

[13] Hess ST, Girirajan TP, Mason MD (2006) Ultra-high resolution imaging by fluorescence photoactivation localization microscopy. Biophys J 91:

Baddeley D, Kaufmann R, Urich A,

[14] Lemmer P, Gunkel M,

*DOI: http://dx.doi.org/10.5772/intechopen.95597*

Lukášová E,Biswas A, Hildenbrand G, Davídková M, Krasavin E, Kleibl Z, Falková I, Ježková L, Štefančíková L, Ševčík J, Hofer M, Bačíková A, Matula P, Boreyko A, Vachelová J, Michaelidisová A, Kozubek S (2014) Determining OMICS spatiotemporal dimensions using exciting new

nanoscopy techniques to asses complex cell responses to DNA damage – PART A (Radiomics). Crit. Rev. Eukaryot. Gene

[2] Falk M, Hausmann M, Lukášová E,

Davídková M, Krasavin E, Kleibl Z, Falková I, Ježková L, Štefančíková L, Ševčík J, Hofer M, Bačíková A, Matula P, Boreyko A, Vachelová J, Michaelidisová A, Kozubek S (2014) Determining OMICS spatiotemporal dimensions using exciting new nanoscopy techniques to asses complex cell responses to DNA damage – PART B (Structuromics). Crit. Rev. Eukaryot. Gene Express. 24: 225-247

[3] Bolus NE (2001). Basic review of radiation biology and terminology. J. Nucl. Med. Technol. 29: 67-73; test

[4] Martin CJ, Sutton DG, editors. Practical Radiation Protection in Healthcare. 2nd edit. Oxford University

Press; 2015.DOI: 10.1093/med/ 9780199655212.001.0001

[5] Falk M, Hausmann M (2021) A paradigm revolution or just better resolution – will newly emerging super-resolution techniques recognize chromatin architecture as a key factor in radiation DNA damaging and repair regulation? Cancers, 13, 18. https:// dx.doi.org/10.3390/cancers13010018

[6] Cremer C, Masters BR (2013) Resolution enhancement techniques in microscopy. Eur Phys J H 38:

**References**

[1] Falk M, Hausmann M,

Express. 24: 205-223

Biswas A, Hildenbrand G,

*Super-Resolution Radiation Biology: From Bio-Dosimetry towards Nano-Studies of DNA Repair… DOI: http://dx.doi.org/10.5772/intechopen.95597*
