**Other declarations**

The research in this chapter was approved by the Charles F. and Joanne Knight Alzheimer disease Research Center (Knight ADRC) and Movement Disorders Center (MDC) Leadership Committees (Ethics approval reference number: T1705).

**217**

**Author details**

Huifangjie Li and Jinbin Xu\*

St. Louis, MO, United States

\*Address all correspondence to: jinbinxu@wustl.edu

provided the original work is properly cited.

Mallinckrodt Institute of Radiology, Washington University School of Medicine,

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

*The Striatal DNA Damage and Neurodegenerations DOI: http://dx.doi.org/10.5772/intechopen.93706*

LBD Lewy body disease

6-OHDA 6-hydroxydopamine

HD Huntington's disease

AOA ataxia oculomotor apraxia N6FFA or kinetin N6-furfuryladenine

APTX aprataxin

NFTs neurofibrillary tangles PDD Parkinson disease dementia

ADHD attention-deficit hyperactivity disorder

SNc substantia nigra pars compact

GWAS genome-wide association studies

TDP1 tyrosyl DNA-phosphodiesterase 1

PNKP polynucleotide kinase/phosphatase
