**Author details**

Safa A. Faraj1,2\* and Naeem M. Al-Abedy3

1 Department of Pediatrics, College of Medicine, Wasit University, Kut, Iraq


\*Address all correspondence to: safaafaraj@uowasit.edu.iq

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Serum Hepcidin Hormone Level and Its Genes Polymorphism*

key regulator of iron metabolism. Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche

[9] Petrak J, Havlenova T, Krijt M, Behounek M, Franekova J, Cervenka L, et al. Myocardial iron homeostasis and hepcidin expression in a rat model of heart failure at different levels of dietary iron intake. Biochimica et Biophysica Acta (BBA) - General Subjects. 2019;

[10] Leitch HA, Thachil J. Iron physiology, iron overload, and the porphyrias. Am Soc Hematol Self-Assessment Program, Sixth Ed David P Steensma, Md, Adam Cuker, Md, Ms, Christine L Kempton, Md, Msc, Grzegorz S Nowakowski, MD Download Cit file Ris Ref Manag EasyBib Bookends Mendeley Pap EndNote Ref Works BibTex Close

[11] Skalnaya MG, Skalny AV. Essential Trace Elements in Human Health: A physician's View. Tomsk: Publishing House of Tomsk State University;

[12] Dlouhy AC, Bailey DK, Steimle BL, Parker HV, Kosman DJ. Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux. Journal of Biological Chemistry.

Fakultät; 2018

**1863**(4):703-713

Search. 2016

2018. p. 224

2019;**294**(11):4202-4214

2008;**138**(11):2284-2288

2001;**276**(11):7806-7810

Ganz T. Hepcidin, a urinary

[13] Collins JF, Wessling-Resnick M, Knutson MD. Hepcidin regulation of iron transport. The Journal of Nutrition.

[14] Park CH, Valore EV, Waring AJ,

antimicrobial peptide synthesized in the liver. Journal of Biological Chemistry.

*DOI: http://dx.doi.org/10.5772/intechopen.93622*

[2] Merryweather-Clarke AT, Cadet E, Bomford A, Capron D, Viprakasit V, Miller A, et al. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Human Molecular Genetics. 2003;**12**(17):

[3] Fekri K, Rasouli NA, Zavareh SA, Jalil M, Moradi F, Hosseinpour M, et al. Hepcidin and HFE polymorphisms and ferritin level in β-thalassemia major. International Journal of Hematology-Oncology and Stem Cell Research.

[4] Dhillon BK, Prakash S, Chandak GR, Chawla YK, Das R. H63D mutation in HFE gene is common in Indians and is associated with the European haplotype. Journal of Genetics. 2012;**91**(2):229-232

[5] Sharma V, Panigrahi I, Dutta P, Tyagi S, Choudhry VP, Saxena R. HFE mutation H63D predicts risk of iron over load in thalassemia intermedia irrespective of blood transfusions. Indian Journal of Pathology & Microbiology. 2007;**50**(1):82-85

[6] do Rio Preto J, Oliveira TM, Souza FP, Jardim AC, Cordeiro JA, Pinho JR, et al. HFE gene mutations in Brazilian thalassemic patients. Brazilian Journal of Medical and Biological

[7] Jazayeri M, Bakayev V, Adibi P, Rad FH, Zakeri H, Kalantar E, et al. Frequency of HFE gene mutations in Iranian beta-thalassaemia minor patients. European Journal of Haematology. 2003;**71**(6):408-411

[8] Abbas I. Development of LC-MS/ MS methods for the quantitative determination of hepcidin-25, a

Research. 2006;**39**:12

[1] Ganz T. Hepcidin and iron regulation, 10 years later. Blood.

2011;**117**(17):4425-4433

**References**

2241-2247

2019;**13**(1):42

*Serum Hepcidin Hormone Level and Its Genes Polymorphism DOI: http://dx.doi.org/10.5772/intechopen.93622*
