**Chapter 13**

*Genetic Variation*

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes. Nat Genet. 2014;46(3):294-8.

[65] Moltke I, Grarup N, Jørgensen ME, et al. A common Greenlandic *TBC1D4*

resistance and type 2 diabetes. Nature.

[66] UK10K Consortium; Walter K, Min JL, Huang J, et al. The UK10K project identifies rare variants in health and disease. Nature. 2015;526(7571):

variant confers muscle insulin

[67] Zhang Y, Kent JW, Lee A, Cerjak D, et al. Fatty acid binding protein 3 (*fabp3*) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population.

[68] Kaati G, Bygren LO, Pembrey M, Sjostrom M. Transgenerational response to nutrition, early life circumstances and longevity. Eur J Hum Genet.

[69] Flannick J, Florez JC. Type 2

[70] Hakim O, Misteli T. SnapShot: chromosome confirmation capture. *Cell.*

diabetes: genetic data sharing to advance complex disease research. Nat Rev

2007;15(7):784-90.

Genet*.* 2016;17:535-549.

2012;148:1068.e1-1068.e2.

[72] Chen Z, Yu H, Shi X,

Warren CR, Lotta LA, Friesen M, Meissner TB, Langenberg C,

Wabitsch M, Wareham N, Benson MD, Gerszten RE, Cowan CA. Functional screening of candidate causal genes for insulin resistance in human

preadipocytes and adipocytes. Circ Res.

[71] Nica AC, Dermitzakis ET. Expression quantitative trait loci: present and future. *Philos Trans R Soc Lond B Biol Sci.* 2013;368:20120362.

2014;512(7513):190-3.

82-90.

**226**

2020;126:330-6.
