**11. Conclusion**

The pandemic COVID-19 by SARS-CoV-2 coronavirus is multifactorial in which human inheritances might play a pivotal role together with the co-morbidity diseases and other risk factors. The disease clinical course has been depending on the link between genetic variants, such as the CYP2D6 enzyme system, HO-1 (anti-inflammatory gene), and ACE-2 enzyme. Beside ACE2 polymorphisms, there is TMPRSS2 gene variance that possibly changes the pathogenicity of the virus by changing the interaction between ACE2 and SARS-CoV-2 virus. A good characterization of functional polymorphisms and the host genetics can assist in identifying the pathophysiology of the disease pathway to stratify the risk evaluation and to personalize the treatment procedures.

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**Author details**

Mahmood A. Al-Azzawi1

\* and Moustafa A. Sakr2

2 Genetic Engineering Institute, University of Sadat City, Sadat City, Egypt

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

1 College of Dentistry, Al-Ayen University, An-Nasiriyah, Iraq

\*Address all correspondence to: mmahmood41@yahoo.com

provided the original work is properly cited.

*Co-Evolution between New Coronavirus (SARS-CoV-2) and Genetic Diversity…*

*DOI: http://dx.doi.org/10.5772/intechopen.93676*
