**Abstract**

CMV virus is worldwide, especially in temperate regions, where it can infect more than 800 plant species belonging to about 40 families. Although the main factor that the plant takes in order not to be infected is because it has preventive means that inhibit the direction of pathogens so that the infection occurs under conditions that suit it and suit its success. Cucumber Mosaic Virus belongs to the group of plant viruses to the genus Cucumovirus, as the virus particles are symmetrically spherical, not enveloped, with a diameter of 29 nm, and the virus has several strains that differ among themselves in terms of factors, symptoms of infection and methods of transmission. The stimulation of induced systemic resistance (ISR) leads to the interest of many researchers. Many types of research and studies have been conducted in the field of biochemical changes in the form of modulating the host's cell wall. The production of phytoalexin. And the manufacture of pathogen-related proteins (Pathogenesis Related Protein). It has been indicated that treatment with various factors, for example (non-pathogenic organisms, weak pathogens, chemical and industrial compounds, plant extracts, nutritional supplements) has the ability to activate plant defense mechanisms and induce systemic resistance against pathogens. In the field of biological control, bacterial types have been used on many pathogens, including fluorescens Pseudomonas and Bacillus subtillus, as they have proven effective in controlling many different fungal and bacterial pathogens as well as viral, and the reason is due to the ability of the bacteria to produce many growth regulators and thus stimulate resistance The systemic plant and the production of phytotoxins are in addition to being one of the most important growth stimuli. New methods have been used to resist viruses by using natural nutritional supplements with effective effect, because plants have defensive means, and for this reason, the use of these supplements can be stimulated in addition to the preventive aspect, a decrease in infection parameters, and an increase in growth indicators and outcome. Several methods have been relied upon to diagnose viruses, the first being the symptoms of reagents, and they are of basic methods. After that, serological tests were adopted, which are highly specialized and accurate in diagnosing viruses, and electron microscopy was used as a method to detect the size and shape of viruses. Polymerase Chain Reaction (PCR) technology is a fast and accurate way to detect plant viruses compared to other tests, such as the ELISA test and plant reagents.

**Keywords:** biological control, cucumber mosaic virus, spirulina, food supplements
