**8. Maintaining glucose homeostasis**

Diabetes features dysregulated glucose metabolism characterized by increased hepatic glucose production and decreased glucose oxidation. This eventually leads to deterioration in glucose control. Alkhalidy *et al* reported that kaempferol ameliorate hyperglycemia and enhance glucose tolerance in insulin deficient mice [45]. Diabetic mice displayed significantly higher pyruvate carboxylase activity. Kaempferol treatment suppressed the elevated pyruvate carboxylase activity and glucose-6 phosphatase activity in the liver suggesting that kaempferol may improve glycemic control in diabetes in part through suppressing gluconeogenesis in the liver via the regulation of pyruvate carboxylase, the first and critical step in gluconeogenesis [45]. It could therefore be a strategy for maintaining glucose homeostasis by targeting the glucose production and metabolic pathways.
