**9. Modulation of antioxidant profile**

Generation of reactive oxygen species and free radicals contributes to the pathogenesis of diabetes [46]. This increased ROS production overruns the cellular antioxidant defense system leading to oxidative stress and damage [47]. Some diabetes research confirm this phenomenon in different diabetes model [48, 49]. Catalase, superoxide dismutase and glutathione are reduced significantly in diabetes [50]. Kaempferol reversed the alterations on oxidative stress markers in alloxaninduced diabetic rats [29].
