**7. References**


doxorubicin. All results suggest that this easy- manufactured, cost-effective nanoscale

This work was supported by National Natural Science Foundation of China (50673041, 30771036 and BK2007144), National Basic Research Foundation of China (973 Program 2006CB503909, 2004CB518603), Key Program for Science and Technology Research from Chinese Ministry of Education (01005), Young Investigator Grant (NCET-04-0466), the Chinese National Programs for High Technology Research and Development (863 Program

Bigotte, L. (1985). Doxorubicin as a fluorescent nuclear marker in tumors of the human

Bodley, A.; Liu, LF. & Israel, M. (1989). DNA topoisomerase II-mediated interaction of

Cheng, X.; Gao, F. & Xiang, J. (2011). Galactosylated alpha,beta-poly[(2-hydroxyethyl)-L-

Combs, AB. & Acosta, D. (1990). Toxic mechanisms of the heart: a review. *Toxicologic* 

Deryugina, EI. & Quigley, JP. (2006). Matrix metalloproteinases and tumor metastasis.

Dorr, RT.; Shipp, NG. & Lee, KM. (1991). Comparison of cytotoxicity in heart cells and

Eklund, A. (1976). On the determination of available lysine in casein and rapeseed protein

Eliyahu, H.; Barenholz, Y. & Domb, AJ. (2005). Polymers for DNA delivery. *Molecules.* Vol.

Emonard, H. & Grimaud, JA. (1990). Matrix metalloproteinases. A review. *Cellular and Molecular Biology.* Vol. 36, No. 2, (January 1990), pp. 131-53, ISSN 0415-5680 Ferrans, VJ. (1978). Overview of cardiac pathology in relation to anthracycline

Ferreira, AL.; Matsubara, LS. & Matsubara, BB. (2008). Anthracycline-induced

*Pathology.* Vol. 18, No.4, (January 1990), pp. 583-96, ISSN 0192-6233

nervous system: a simple and reliable staining technique. *Clinical Neuropathology.*

doxorubicin and daunorubicin congeners with DNA. *Cancer Research.* Vol. 49,

aspartamide]-bound doxorubicin: improved antitumor activity against hepatocellular carcinoma with reduced hepatotoxicity. *Anticancer Drugs*. Vol. 22,

*Cancer and Metastasis Reviews.* Vol. 25, No.1, (March 2006), pp. 9-34, ISSN 0167-7659

tumor cells exposed to DNA intercalating agents in vitro. *Anticancer Drugs*. Vol. 2,

concentrates using 2,4,6-trinitrobenzenesulphonic acid (TNBS) as a reagent for free epsilon amino group of lysine. *Analytical Biochemistry.* Vol. 70, No.2, (February

cardiotoxicity. *Cancer treatment reports.* Vol. 62, No. 6, (June 1978), pp. 955-61, ISSN

cardiotoxicity. *Cardiovascular and Hematological Agents in Medicinal Chemistry.* Vol.

2006AA02Z177), China Postdoctoral Science Fundation 200801364 and 20080431077.

Vol. 4, No.5, (September 1985), pp. 220-6, ISSN 0722-5091

No.21, (October 1989), pp. 5969-78, ISSN 0008-5472

No.2, (February 2011), pp. 136-47, ISSN 0959-4973

No.1, (February 1991), pp. 27-33, ISSN 0959-4973

10, No. 1, (November 2005), pp. 36-64, ISSN 1420-3049

36, No. 2, (January 2008), pp. 131-53, ISSN 0415-5680

1976), pp. 434-9, ISSN 0003-2697

0361-5960

formulation of doxorubicin hold great promise to be used to clinical practices.

**6. Acknowledgements** 

**7. References** 


Yoshikawa, K. & Kitaoka, H. (1971). Prolonged intra-aortic infusion therapy with anti-tumor agents for advanced cancer of the stomach, colon and rectum. *The Japanese Journal of Surgery.* Vol. 1, No.4, (December 1971), pp. 256-62, ISSN 0047-1909

Yoshikawa, K. & Kitaoka, H. (1971). Prolonged intra-aortic infusion therapy with anti-tumor

*Surgery.* Vol. 1, No.4, (December 1971), pp. 256-62, ISSN 0047-1909

agents for advanced cancer of the stomach, colon and rectum. *The Japanese Journal of* 
