*Spatiotemporal Regulation of Cell–Cell Adhesions DOI: http://dx.doi.org/10.5772/intechopen.97009*

The CarH tetramer irreversibly degrades when exposed to blue-green light and hence the CarH based cell–cell adhesion can only be reversed once [59, 60].

Light responsive heterophilic cell–cell adhesions, can be achieved by proteins that heterodimerize under light to form cell–cell adhesions. For this purpose, different heterodimerization pairs that form under blue light and reverse in the dark were used. These include the binding of the improved light-induced dimer (iLID) to Nano [61], the binding of the Vivid-based proteins nMag and pMag and the previously-described binding of CRY2 to CIBN. These different protein pairs provide different interaction strengths, reversion kinetics in the dark, and protein–protein dynamics.
