*1.4.3 Self-isolated*

In a self-isolated system the two cell types form separate assemblies because the work of adhesion between the cell types is smaller than the work of cohesion within either population. In this case each cell type will self-isolate with no intermixing.

Numerous studies with cells expressing different types and amounts of cadherins have demonstrated these sorting schemes [34–36]. These studies show that the differences in homophylic and heterophilic cell–cell adhesions determine the outcome and the origin of these differences on adhesions are not important for the result.
