*Epigenetic DOI: http://dx.doi.org/10.5772/intechopen.99964*

glucocorticoid receptor gene methylation: a systematic review. Biol Psychiatry. 2016;79(2):87-96.

[33] A comprehensive review of the literature describing experiencedependent changes in DNA methylation patterns at the NR3C1 locus in humans and model organisms.

[34] McGowan PO, Sasaki A, D'Alessio AC, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci. 2009;12(3):342-348.

[35] Radtke KM, Ruf M, Gunter HM, et al. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry. 2011;1:e21.

[36] Mulligan CJ, D'Errico NC, Stees J, Hughes DA. Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight. Epigenetics. 2012;7(8):853-857.

[37] Labonte B, Yerko V, Gross J, et al. Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry. 2012;72(1):41-48.

[38] Tyrka AR, Parade SH, Eslinger NM, et al. Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children. Dev Psychopathol. 2015;27(2):577-585.

[39] Weder N, Zhang H, Jensen K, et al. Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry. J Am Acad Child Adolesc Psychiatry. 2014;53(4): 417-424.e415.

[40] van der Knaap LJ, Riese H, Hudziak JJ, et al. Glucocorticoid receptor gene (NR3C1) methylation following stressful events between birth and adolescence. The TRAILS study. Transl Psychiatry. 2014;4:e381.

[41] Braithwaite EC, Kundakovic M, Ramchandani PG, Murphy SE, Champagne FA. Maternal prenatal depressive symptoms predict infant NR3C1 1F and BDNF IV DNA methylation. Epigenetics. 2015;10(5):408-417.

[42] Murgatroyd C, Quinn JP, Sharp HM, Pickles A, Hill J. Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene. Transl Psychiatry. 2015;5:e560.

[43] Radtke KM, Schauer M, Gunter HM, et al. Epigenetic modifications of the glucocorticoid receptor gene are associated with the vulnerability to psychopathology in childhood maltreatment. Transl Psychiatry. 2015;5:e571.

[44] Kertes DA, Kamin HS, Hughes DA, Rodney NC, Bhatt S, Mulligan CJ. Prenatal maternal stress predicts methylation of genes regulating the hypothalamic–pituitary–adrenocortical system in mothers and newborns in the Democratic Republic of Congo. Child Dev. 2016;87(1):61-72.

[45] Kino T, Hurt DE, Ichijo T, Nader N, Chrousos GP. Noncoding RNA gas5 is a growth arrest- and starvationassociated repressor of the glucocorticoid receptor. Sci Signal. 2010;3(107):ra8.

[46] Hudson WH, Pickard MR, de Vera IM, et al. Conserved sequencespecific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nat Commun. 2014;5:5395.

[47] Vreugdenhil E, Verissimo CS, Mariman R, et al. MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain. Endocrinology. 2009;150(5):2220-2228.

[48] Pan-Vazquez A, Rye N, Ameri M, et al. Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety. Mol Brain. 2015;8:40.

[49] Melas PA, Wei Y, Wong CC, et al. Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. Int J Neuropsychopharmacol. 2013;16(7): 1513-1528.

[50] Cao-Lei L, Massart R, Suderman MJ, et al. DNA methylation signatures triggered by prenatal maternal stress exposure to a natural disaster: Project Ice Storm. PLoS One. 2014;9(9):e107653.

[51] Khulan B, Manning JR, Dunbar DR, et al. Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state. Transl Psychiatry. 2014;4:e448.

[52] Non AL, Hollister BM, Humphreys KL, et al. DNA methylation at stress-related genes is associated with

exposure to early life institutionalization. Am J Phys Anthropol. 2016;161(1):84-93.

[53] Houtepen LC, Vinkers CH, Carrillo-Roa T, et al. Genomewide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans [•• Evidence is presented which indicates that increased DNA methylation at the KITLG locus is a mediator of childhood trauma-induced blunting of the cortisol response to stress in adulthood.]. Nat Commun. 2016;7:10967.

[54] Suderman M, Borghol N, Pappas JJ, et al. Childhood abuse is associated with methylation of multiple loci in adult DNA. BMC Med Genomics. 2014;7:13.

[55] Miller CA, Sweatt JD. Covalent modification of DNA regulates memory formation. Neuron. 2007;53:857-869.

[56] Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH. Recovery of learning and memory is associated with chromatin remodelling. Nature. 2007;447:178-182.

[57] Kuzumaki N, Ikegami D, Tamura R, Hareyama N, Imai S, Narita M, et al. Hippocampal epigenetic modification at the brainderived neurotrophic factor gene induced by an enriched environment. Hippocampus. 2011;21:127-132.

[58] Roth TL, Zoladz PR, Sweatt JD, Diamond DM. Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of posttraumatic stress disorder. J Psychiatr Res. 2011;45:919-926.

[59] sankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9:519-25.

[60] Covington HE 3rd, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O, et al. Antidepressant actions of histone deacetylase inhibitors. J Neurosci. 2009;29:11451-11460.

[61] Hollis F, Wang H, Dietz D, Gunjan A, Kabbaj M. The effects of repeated social defeat on long-term depressive-like behavior and shortterm histone modifications in the hippocampus in male Sprague-Dawley rats. Psychopharmacology (Berl). 2010;211:69-77.

### *Epigenetic DOI: http://dx.doi.org/10.5772/intechopen.99964*

[62] Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A. Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice. Nat Neurosci. 2010;13:1351-1353.

[63] Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, et al. Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron. 2011;69:359-372.

[64] Champagne FA. Epigenetic mechanisms and the transgenerational effects of maternal care. Front Neuroendocrinol. 2008;29:386-397.

[65] Champagne FA, Meaney MJ. Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model. Biol Psychiatry. 2006;59:1227-1235.

[66] Champagne FA, Meaney MJ. Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behav Neurosci. 2007;121:1353-1363.

[67] Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry. 2009;65:760-769.

[68] Weaver JR, Susiarjo M, Bartolomei MS. Imprinting and epigenetic changes in the early embryo. Mamm Genome. 2009;20:532-543.

[69] Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 2005;308:1466-1469.

[70] Franklin TB, Russig H, Weiss IC, Graff J, Linder N, Michalon A, et al. Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry. 2010;68:408-415.

[71] Wilkinson R, Pickett K. The Spirit Level: Why Equality is Better for Everyone. London, UK: Penguin; 2010.

[72] Marmot M. The Health Gap: the Challenge of an Unequal World. London, UK: Bloomsbury Publishing; 2015.

[73] Bourdieu P. The Forms Of Capital. In: Handbook Of Theory And Research For The Sociology Of Education. Greenwood, New York, NY, USA, 241-258 (1986).

[74] Coleman J. Foundations of Social Theory. Cambridge, USA: Harvard University Press; 1994.

[75] Putnam RD. Bowling Alone: The Collapse and Revival of American Community. NY, USA: Simon and Schuster; 2001.

[76] Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull. 2004;130(3):355-391.

[77] Gilbert P, McEwan K, Bellew R, Mills A, Gale C. The dark side of competition: how competitive behaviour and striving to avoid inferiority are linked to depression, anxiety, stress and self-harm. Psychol Psychother. 2009;82(Pt 2):123-136.

[78] Layte R. The association between income inequality and mental health: testing status anxiety, social capital, and neo-materialist explanations. Eur Sociol Rev. 2011;28(4):498-511.

[79] Layte R, Whelan CT. Who feels inferior? A test of the status anxiety hypothesis of social inequalities in health. Eur Sociol Rev. 2014;30(4): 525-535.

[80] Mascaro O, Csibra G. Representation of stable social dominance relations by

human infants. Proc Natl Acad Sci USA. 2012;109(18):6862-6867.

[81] Frankel D, Arbel T. Group formation by two-year olds. Int J Behav Dev. 1980;3(3):287-298.

[82] Dickerson SS, Gable SL, Irwin MR, Aziz N, Kemeny ME. Social-evaluative threat and proinflammatory cytokine regulation: an experimental laboratory investigation. Psychol Sci. 2009;20(10):1237-1244.

[83] Chiang JJ, Eisenberger NI, Seeman TE, Taylor SE. Negative and competitive social interactions are related to heightened proinflammatory cytokine activity. Proc Natl Acad Sci USA. 2012;109(6):1878-1882.

[84] Packard CJ, Bezlyak V, McLean JS, et al. Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study. BMC Public Health. 2011;11:42.

[85] Kumari M, Shipley M, Stafford M, Kivimaki M. Association of diurnal patterns in salivary cortisol with all-cause and cardiovascular mortality: findings from the Whitehall II study. J Clin Endocrinol Metab. 2011;96(5): 1478-1485.

[86] Kiecolt-Glaser JK, Gouin JP, Hantsoo L. Close relationships, inflammation, and health. Neurosci Biobehav Rev. 2010;35(1):33-38.

[87] Aslund C, Starrin B, Nilsson KW. Social capital in relation to depression, musculoskeletal pain, and psychosomatic symptoms: a cross-sectional study of a large population-based cohort of Swedish adolescents. BMC Public Health. 2010;10:715.

[88] Aslund C, Starrin B, Nilsson KW. Psychosomatic symptoms and low psychological well-being in relation to employment status: the influence of social capital in a large cross-sectional study in Sweden. Int J Equity Health. 2014;13:22.

[89] Youm Y, Laumann EO, Ferraro KF, et al. Social network properties and self-rated health in later life: comparisons from the Korean social life, health, and aging project and the national social life, health and aging project. BMC Geriatr. 2014;14:102.

[90] Uphoff EP, Pickett KE, Cabieses B, Small N, Wright J. A systematic review of the relationships between social capital and socioeconomic inequalities in health: a contribution to understanding the psychosocial pathway of health inequalities. Int J Equity Health. 2013;12:54.

[91] Fisher PA, Gunnar MR, Chamberlain P, Reid JB. Preventive intervention for maltreated preschool children: impact on children's behavior, neuroendocrine activity, and foster parent functioning. J Am Acad Child Adolesc Psychiatry. 2000;39(11): 1356-1364.

[92] Evans GW, Kim P, Ting AH, Tesher HB, Shannis D. Cumulative risk, maternal responsiveness, and allostatic load among young adolescents. Dev Psychol. 2007;43(2):341-351.

[93] Chen E, Miller GE, Kobor MS, Cole SW. Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Mol Psychiatry. 2011;16(7):729-737.

[94] Miller GE, Brody GH, Yu T, Chen E. A family-oriented psychosocial intervention reduces inflammation in

## *Epigenetic DOI: http://dx.doi.org/10.5772/intechopen.99964*

low-SES African American youth. Proc Natl Acad Sci USA. 2014;111(31):11287-11292.

[95] Hostinar CE, Sullivan RM, Gunnar MR. Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitaryadrenocortical axis: a review of animal models and human studies across development. Psychol Bull. 2014;140(1):256-282.

[96] Borghol N, Suderman M, McArdle W, et al. Associations with early-life socio-economic position in adult DNA methylation. Int J Epidemiol. 2012;41(1):62-74.

[97] Lam LL, Emberly E, Fraser HB, et al. Factors underlying variable DNA methylation in a human community cohort. Proc Natl Acad Sci USA. 2012;109 Suppl. 2:17253-17260.

[98] McGuinness D, McGlynn LM, Johnson PC, et al. Socioeconomic status is associated with epigenetic differences in the pSoBid cohort. Int J Epidemiol. 2012;41(1):151-160.

[99] Needham BL, Smith JA, Zhao W, et al. Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: the multi-ethnic study of atherosclerosis. Epigenetics. 2015;10(10):958-969.

[100] Stringhini S, Polidoro S, Sacerdote C, et al. Life-course socioeconomic status and DNA methylation of genes regulating inflammation. Int J Epidemiol. 2015;44(4):1320-1330.

[101] Fryers T, Melzer D, Jenkins R, Brugha T. The distribution of the common mental disorders: social inequalities in Europe. Clin Pract Epidemiol Ment Health. 2005;1:14.

[102] Swartz JR, Hariri AR, Williamson DE. An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents. Mol Psychiatry. 2016; https://doi.org/10.1038/ mp.2016.82.; Epub ahead of print.

[103] Beach SR, Brody GH, Todorov AA, Gunter TD, Philibert RA. Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet B Neuropsychiatr Genet. 2010;153b(2): 710-3.

[104] Beach SR, Brody GH, Lei MK, Kim S, Cui J, Philibert RA. Is serotonin transporter genotype associated with epigenetic susceptibility or vulnerability? Examination of the impact of socioeconomic status risk on African American youth. Dev Psychopathol. 2014;26(2):289-304.

[105] Zhao J, Goldberg J, Bremner JD, Vaccarino V. Association between promoter methylation of serotonin transporter gene and depressive symptoms: a monozygotic twin study. Psychosom Med. 2013;75(6):523-529.

[106] Nikolova YS, Koenen KC, Galea S, et al. Beyond genotype: serotonin transporter epigenetic modification predicts human brain function. Nat Neurosci. 2014;17(9):1153-1155.

[107] Swartz JR, Knodt AR, Radtke SR, Hariri AR. A neural biomarker of psychological vulnerability to future life stress. Neuron. 2015;85(3): 505-511.

[108] Swartz JR, Williamson DE, Hariri AR. Developmental change in amygdala reactivity during adolescence: effects of family history of depression and stressful life events. Am J Psychiatry. 2015;172(3):276-283.

[109] Yehuda R, Flory JD, Bierer LM, et al. Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with post-traumatic stress disorder. Biol Psychiatry. 2015;77(4):356-364.

[110] Sadeh N, Spielberg JM, Logue MW, et al. SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans. Mol Psychiatry. 2016;21(3):357-363.

[111] Boks MP, Rutten BP, Geuze E, et al. SKA2 methylation is involved in cortisol stress reactivity and predicts the development of post-traumatic stress disorder (PTSD) after military deployment. Neuropsychopharmacology. 2016;41(5):1350-1356.

[112] Guintivano J, Brown T, Newcomer A, et al. Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. Am J Psychiatry. 2014;171(12):1287-1296.

[113] Kaminsky Z, Wilcox HC, Eaton WW, et al. Epigenetic and genetic variation at SKA2 predict suicidal behavior and posttraumatic stress disorder. Transl Psychiatry. 2015;5:e627.

[114] Yehuda R, Daskalakis NP, Bierer LM, et al. Holocaust exposure induced intergenerational effects on FKBP5 methylation. Biol Psychiatry. 2016;80(5):372-380.

[115] Cunliffe VT. The epigenetic impacts of social stress: how does social adversity become biologically embedded? Epigenomics. 2016;8(12):1653-1669.

Section 3
