**8. Conclusion**

Ischemia reperfusion injury is a well-defined threat to the liver during periods of interruption and restoration of oxygen delivery as occurs in certain procedures as hepatic resections and orthotopic liver transplantations. Relative NO deficiency is central in the pathogenesis of this injury. Replacing NO per se either by inhalation, nitrate anion or via donor drugs represents a novel means in ameliorating IRI. Further randomized controlled drugs are needed to evaluate this therapy in patients undergoing operative procedures causing IRI.

#### **9. References**


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