**8. Complications of immunosuppression**

Clinical immunosuppression strategies involve striking a balance between freedom from rejection episodes and freedom from the toxicity and complications of immunosuppressive treatment regimens. As the number of rejection episodes decreases, the likelihood of opportunistic infections, late malignancy and drug toxicity increases.

The specific toxicities of the immunosuppressive drugs are described in the sections pertaining to each drug. In general, the goal of multidrug therapy is to decrease the toxicities that are seen with higher doses of individual drugs.
