**3.7 Dose and duration of exposure to EDCs**

The intensity of exposure to EDCs varies between the United States of America (USA) and the EU because of differences in regulations. For example, EDC exposure is much higher for organophosphate pesticides in the EU and for polybrominated diphenyl ethers in the USA [47].

Humans are at the top of food chain. They may store large doses of multiple EDCs according to the process of bioaccumulation and bioamplification, generating effects with unknown consequences [12]. No safe dose of EDC exposure can be established. Information on chronic low-dose exposure to EDCs is relatively limited.
