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## Meet the editor

Prof. Dr. Patricia Bozzetto Ambrosi graduated with degrees in Medicine from the University of Caxias do Sul, Brazil, and the University of Rome Tor Vergata, Italy. She is a former researcher in morphophysiology at the University of Córdoba/Reina Sofia Hospital, Córdoba, Spain. She graduated in Neurology/Neurosurgery at the Hospital of Restauração, SES, Brazil, and Neuroradiology/Radiodiagnostics at Pierre and Marie Curie University,

France. She holds a master's degree in Medicine from the University of Nova Lisboa, Portugal, and in Behavioral Sciences and Neuropsychiatry from the University of Pernambuco, Brazil. She also has a Ph.D. in Biological Sciences from the University of Pernambuco/Paris Diderot University, France. She is a former fellow in Interventional Neuroradiology in France at the Ophthalmological Foundation Adolphe de Rothschild, Beaujon Hospital, and Hospices Civils de Strasbourg. She was Praticien Associé in Interventional Neuroradiology at Neurologique Hospital Pierre Wertheimer, University of Lyon Claude Bernard, France, and visiting professor of the University of Paris Diderot-Neuri Beaujon. Dr. Ambrosi is an independent consultant/supervisor in neurology, neuroradiology, neuroendovascular, and imaging, and a clinical professor of medicine. She has also been an academic collaborator researcher in the Cardiovascular Department, University of Leicester, England. She has experience in innovative research for the development of new technologies and neurosciences. She is also an academic editor and reviewer of several scientific publications about neurological diseases.

Contents

**Section 1**

**Section 2**

**Section 3**

*by Roxana Deleanu*

*and Hideki Nakano*

Anatomy of Cerebellum

*by Rajasekhar Sajja Srinivasa Siva Naga*

Impact of Nutrition in Spinocerebellar Ataxia

**Preface XI**

Background: Concepts and Features **1**

**Chapter 1 3**

**Chapter 2 15**

Classification: Subtypes and Symptoms **29**

**Chapter 3 31**

Interventions: Medical and Non Medical **47**

**Chapter 4 49**

**Chapter 5 89**

**Chapter 6 111**

Living and Coping with Spinocerebellar Ataxia: Palliative Care Approach

*by Donnette Alicia Wright and Kadiann Peta-Gay Hewitt-Thompson*

International Classification of Functioning, Health and Disability (ICF) Conceptual Approach towards Spinocerebellar Ataxia *by Kevin Triangto, Steven Setiono and Herdiman Bernard Purba*

Human Pluripotent Stem Cell-Derived Cerebellar Neurons:

*by Akiyoshi Matsugi, Kyota Bando, Yutaka Kikuchi, Yuki Kondo* 

*by Caroline Bozzetto Ambrosi and Patricia Bozzetto Ambrosi*

From Development to Modeling Cerebellar Ataxias

Rehabilitation for Spinocerebellar Ataxia

### Contents


Preface

Spinocerebellar ataxia (SCA) is a neurological pathology that is among the most challenging pathologies in the current medical scenario. SCA has a wide spectrum of clinical presentations, including degenerative and progressive forms with a decline in functional capacity, life-threatening characteristics, and long-standing presentation with great variability in symptoms and clinical severity. Our book addresses the background concepts, generalities, and particularities related to SCA, including clinical, neurological, genetic, and functional aspects. The book also gathers necessary information for functional classification, new approaches to medical and non-medical treatment, and rehabilitation/support, including aspects

The book is divided into three sections. The first section, "Background: Concepts and Features" begins with Chapter 1, "Anatomy of Cerebellum." This chapter examines the functional features, main pathways, and blood supply of the cerebellum as well as clinical generalities and particularities when progressive and slow degeneration of the cerebellum occurs and certain parts of the spinal cord. Chapter 2 discusses the impact of nutrition on SCA, implementing the cyclical impact of this neurological condition on nutritional status and its corresponding impact on disease progression. It also includes recommendations and standardized guidance crucial to expanding the healthcare approach and the overall wellness

In the second section, Chapter 3, aims to help physicians identify the activity and participation aspects of SCA, mainly around the function of mobility that can become a focus of rehabilitation intervention. Neuroplasticity through self-recognition of

The final section deals with medical and non-medical interventions. Chapter 4 approaches the therapies of cerebellar neurons derived from human pluripotent stem cells (PSCs), from development to modeling of cerebellar ataxias. It is noteworthy that PSC technology has emerged as an important tool for the generation of different types of neurons, which are used to better understand the development and pathologies of the human nervous system. Strategies for differentiating human PSCs into cerebellar neurons are presented, followed by a perspective for their further optimization and diversification through the implementation of knowledge of cerebellar development and new cell culture approaches. The reported iPSC-derived in vitro models for cerebellar ataxias are reviewed, followed by a perspective on how to improve these models by generating and exporting cerebellar neurons. Chapter 5 presents a narrative review of rehabilitation, which is an important treatment for SCA. The lack of improvement in ataxia, motor learning deficit, and unstable balance cause incapacity for activities of daily living

of palliative supportive care.

of individuals with SCA.

errors is the main physiology of recovery in SCA.
