*2.1.1 Fungal genome*

The genome of *C. albicans* characterized by numeric rearrangements of chromosomal structures leads to creating genetic rearrangements called chromosome length polymorphisms, reciprocal translocations, and chromosome deletions. These karyotypic modifications followed by changes in the phenotype, which consider a fungal strategy of adaptation. Two species of candida (including *C. albicans* and *C. tropicalis*) have an uncommon trait in which the CUG codon, which usually specifies leucine, in these species it encodes serine. The main feature of *C. albicans* genome is extremely dynamic, and this changeability is a higher benefit for molecular, epidemiological, and population researches for this species [23].
