Contents


Preface

*Candida albicans*, a fungal pathobiont, is the major component of the microbiota communities in healthy adults. It resides in the host's gastrointestinal tract and mouth. *C. albicans* can become pathogenic via overgrowth of the fungus under a variety of conditions. Infection caused by *C. albicans* can form a biofilm that is resistant to antifungal therapeutics and the host immune system. The epithelial cells in mucosa help develop elaborate immune responses again *C. albicans* infection. Genetic mutations play an important role in the virulence of *C. albicans*. Whole-genome sequencing has revealed more identifications of population structure, epidemiological investigations,

This book reviews recent knowledge and the latest research on *C. albicans*, including the mechanism of candidiasis infection, host response, antifungal strategies, biofilms,

Chapter 1 examines several factors of *C. albicans* pathogenesis. It surveys all the underlying variables and components of pathogenesis to improve understanding of these

Chapter 2 discusses the molecular mechanisms of resistance to antifungal agents at the molecular level described in *C. albicans*. The information presented may be helpful for

Chapter 3 reviews current advances in model construction, target identification, and validation. It presents several examples of successful metabolic model construction and

Chapter 4 examines the effect of cell-mediated (T cells) and immune cells (macrophages, neutrophils, and natural killer cells) on *C. albicans* infection. The chapter adds to the understanding of immune responses and antibody-mediated responses fighting infection.

Chapter 5 discusses onychomycosis, a common fungal infection affecting nails. Caused by *C. albicans*, onychomycosis is frequently associated with local or systemic immune disturbances. Microscopic examination and fungal cultures are the gold standard

Chapter 6 discusses *C. albicans* and the risk of miscarriage. Excessive growth of *C. albicans* can cause vulvovaginal candidiasis, which, if chronic and recurrent in pregnant

Understanding the mechanism of *C. albicans* infection can aid in developing proper

**Xinhui Wang**

Xining, China

School of Computer Science, Qinghai Normal University,

and phylogenetic analyses of *Candida* species.

these models' utility in rational drug design.

methods for diagnosing onychomycosis.

treatment and discovering novel drugs.

genetics, and molecular epidemiology of immune responses.

factors' effects on modulate virulence and consequent infection.

discovering new antifungal agents or targets to combat candidiasis.

persons, may contribute to spontaneous abortion or miscarriage.
