**Abstract**

*C. albicans* is by far the most common Candida species causing infection in humans which include superficial and a life- threatening systemic infections. Despite the public health significance of candida infections, phenotypic switching of *C. albicans*, slow mycological diagnosis, limitation of use of antifungal agents due to toxicity, high cost and emergence of resistance have impeded effective treatment. Therefore, a need for safe and potent strategy to prevent this disease is necessary. This chapter discusses the roles of white blood cells as the first line defense mechanism against inactivated *C. albicans*.

**Keywords:** white blood cells, *Candida albicans*, immune response
