**Abstract**

Dengue is the most important arbovirus, many research have contributed to the diagnosis, management, prevention and control of this disease, which will be described in this chapter, for example: the importance of serotypes and genotypes for the development of the disease, the relationship of the viral load between symptomatic and asymptomatic people, the influence of antibodies on the development of the disease, co-infections with microorganisms and chronic diseases, possible reservoirs, the diagnostic assays, cross-reactions in the diagnosis, the influence of climate change on the disease and the vector, mechanisms of transmission of the disease, new drugs and plant extracts with antiviral activity, the dengue vaccine, the results of immunizations, etc. This information gives a concrete idea of the advances and challenges against this disease.

**Keywords:** dengue, dengue virus, arbovirus, flavivirus, *Flaviviridae*
