*Clinical Applications of Strain Imaging in Aortic Valve Disease DOI: http://dx.doi.org/10.5772/intechopen.93341*

[14] Kearney LG, Lu K, Ord M, et al. Global longitudinal strain is a strong independent predictor of all-cause mortality in patients with aortic stenosis. European Heart Journal Cardiovascular Imaging. 2012;**13**:827-833

[15] Kusunose K, Goodman A, Parikh R, et al. Incremental prognostic value of left ventricular global longitudinal strain in patients with aortic stenosis and preserved ejection fraction. Circulation. Cardiovascular Imaging. 2014;**7**:938-945

[16] Salaun E, Casalta AC, Donal E, et al. Apical four-chamber longitudinal left ventricular strain in patients with aortic stenosis and preserved left ventricular ejection fraction: Analysis related with flow/gradient pattern and association with outcome. European Heart Journal Cardiovascular Imaging. 2018;**19**:868-878

[17] Fries B, Liu D, Gaudron P, et al. Role of global longitudinal strain in the prediction of outcome in patients with severe aortic valve stenosis. The American Journal of Cardiology. 2017;**120**:640-647

[18] Goodman A, Kusunose K, Popovic ZB, et al. Synergistic utility of brain natriuretic peptide and left ventricular strain in patients with significant aortic stenosis. Journal of the American Heart Association. 2016;**5**:1-11

[19] Kong WKF, Vollema EM, Prevedello F, et al. Prognostic implications of left ventricular global longitudinal strain in patients with bicuspid aortic valve disease and preserved left ventricular ejection fraction. European Heart Journal Cardiovascular Imaging. 2019;**21**:759-767

[20] Carstensen HG, Larsen LH, Hassager C, Kofoed KF, Jensen JS, Mogelvang R. Association of ischemic heart disease to global and regional longitudinal strain in asymptomatic aortic stenosis. The International Journal of Cardiovascular Imaging. 2015;**31**:485-495

[21] Ilardi F, Marchetta S, Martinez C, et al. Impact of aortic stenosis on layerspecific longitudinal strain: Relationship with symptoms and outcome. European Heart Journal Cardiovascular Imaging. 2019;**21**:408-416

[22] Hyodo E, Arai K, Koczo A, et al. Alteration in subendocardial and subepicardial myocardial strain in patients with aortic valve stenosis: An early marker of left ventricular dysfunction? Journal of the American Society of Echocardiography. 2012;**25**:153-159

[23] Fung MJ, Thomas L, Leung DY. Alterations in layer-specific left ventricular global longitudinal and circumferential strain in patients with aortic stenosis: A comparison of aortic valve replacement versus conservative management over a 12-month period. Journal of the American Society of Echocardiography. 2019;**32**:92-101

[24] Fung MJ, Leung DY, Thomas L. Differential myocardial fibre involvement by strain analysis in patients with aortic stenosis. Heart, Lung & Circulation. 2018;**27**:1357-1367

[25] Delgado V, Tops LF, van Bommel RJ, et al. Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement. European Heart Journal. 2009;**30**:3037-3047

[26] Lee SP, Kim YJ, Kim JH, et al. Deterioration of myocardial function in paradoxical low-flow severe aortic stenosis: Two-dimensional strain analysis. Journal of the American Society of Echocardiography. 2011;**24**:976-983

**56**

*Advances in Complex Valvular Disease*

Lancet. 2006;**368**:1005-1011

2018;**19**:859-867

**References**

Open. 2017;**7**:e012240

2018;**33**:470-478

[4] Ng ACT, Delgado V, Bax JJ. Application of left ventricular strain in patients with aortic and mitral valve disease. Current Opinion in Cardiology.

[5] Mor-Avi V, Lang RM, Badano LP,

echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. Journal of the American Society of Echocardiography. 2011;**24**:277-313

[6] Voigt JU, Pedrizzetti G, Lysyansky P,

echocardiography: Consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. Journal of the American Society of Echocardiography. 2015;**28**:183-193

[7] Nishimura RA, Otto CM, Bonow RO, et al. AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: A report of the American

et al. Definitions for a common standard for 2D speckle tracking

et al. Current and evolving

[1] Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: A population-based study.

College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2017,

[8] Baumgartner H, Falk V, Bax JJ, et al. ESC/EACTS guidelines for the management of valvular heart disease. European Heart Journal. 2017,

[9] Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography. 2015;**28**:1-39 e14

[10] Vollema EM, Sugimoto T, Shen M, et al. Association of left ventricular global longitudinal strain with asymptomatic severe aortic stenosis: Natural course and prognostic value. JAMA Cardiology. 2018;**3**:839-847

[11] Iwahashi N, Nakatani S, Kanzaki H, Hasegawa T, Abe H, Kitakaze M. Acute improvement in myocardial function assessed by myocardial strain and strain rate after aortic valve replacement for aortic stenosis. Journal of the American Society of Echocardiography.

[12] Miyazaki S, Daimon M, Miyazaki T, et al. Global longitudinal strain in relation to the severity of aortic stenosis: A two-dimensional speckle-tracking study. Echocardiography. 2011;**28**:703-708

[13] Magne J, Cosyns B, Popescu BA, et al. Distribution and prognostic significance of left ventricular global longitudinal strain in asymptomatic significant aortic stenosis: An individual participant data meta-analysis. JACC: Cardiovascular Imaging. 2019;**12**:84-92

2006;**19**:1238-1244

2017;**70**:252-289

2017;**38**:2739-2791

[2] Ng ACT, Prihadi EA, Antoni ML, et al. Left ventricular global longitudinal strain is predictive of all-cause mortality independent of aortic stenosis severity and ejection fraction. European Heart Journal Cardiovascular Imaging.

[3] Marciniak A, Glover K, Sharma R. Cohort profile: Prevalence of valvular heart disease in community patients with suspected heart failure in UK. BMJ [27] Bartko PE, Heinze G, Graf S, et al. Two-dimensional strain for the assessment of left ventricular function in low flow-low gradient aortic stenosis, relationship to hemodynamics, and outcome: A substudy of the multicenter TOPAS study. Circulation. Cardiovascular Imaging. 2013;**6**:268-276

[28] Sato K, Seo Y, Ishizu T, et al. Prognostic value of global longitudinal strain in paradoxical low-flow, lowgradient severe aortic stenosis with preserved ejection fraction. Circulation Journal. 2014;**78**:2750-2759

[29] Holmes AA, Taub CC, Garcia MJ, Shan J, Slovut DP. Paradoxical lowflow aortic stenosis is defined by increased ventricular hydraulic load and reduced longitudinal strain. Journal of Cardiovascular Medicine (Hagerstown, Md.). 2017;**18**:87-95

[30] Dahou A, Bartko PE, Capoulade R, et al. Usefulness of global left ventricular longitudinal strain for risk stratification in low ejection fraction, low-gradient aortic stenosis: Results from the multicenter true or pseudo-severe aortic stenosis study. Circulation. Cardiovascular Imaging. 2015;**8**:e002117

[31] Dahou A, Clavel MA, Capoulade R, et al. Right ventricular longitudinal strain for risk stratification in low-flow, lowgradient aortic stenosis with low ejection fraction. Heart. 2016;**102**:548-554

[32] Tadic M, Cuspidi C, Pencic B, et al. The impact of arterial hypertension on left ventricular strain in patients with aortic stenosis and preserved ejection fraction. Journal of Hypertension. 2018;**37**:747-753

[33] Cramariuc D, Gerdts E, Hjertaas JJ, Cramariuc A, Davidsen ES, Matre K. Myocardial function in aortic stenosis— Insights from radial multilayer Doppler strain. Cardiovascular Ultrasound. 2015;**13**:8

[34] Poulsen SH, Sogaard P, Nielsen-Kudsk JE, Egeblad H. Recovery of left ventricular systolic longitudinal strain after valve replacement in aortic stenosis and relation to natriuretic peptides. Journal of the American Society of Echocardiography. 2007;**20**:877-884

[35] Dahl JS, Videbaek L, Poulsen MK, Rudbaek TR, Pellikka PA, Moller JE. Global strain in severe aortic valve stenosis: Relation to clinical outcome after aortic valve replacement. Circulation. Cardiovascular Imaging. 2012;**5**:613-620

[36] Marcus KA, de Korte CL, Feuth T, et al. Persistent reduction in left ventricular strain using two-dimensional speckle-tracking echocardiography after balloon valvuloplasty in children with congenital valvular aortic stenosis. Journal of the American Society of Echocardiography. 2012;**25**:473-485

[37] Kafa R, Kusunose K, Goodman AL, et al. Association of abnormal postoperative left ventricular global longitudinal strain with outcomes in severe aortic stenosis following aortic valve replacement. JAMA Cardiology. 2016;**1**:494-496

[38] Naji P, Shah S, Svensson LG, et al. Incremental prognostic use of left ventricular global longitudinal strain in asymptomatic/minimally symptomatic patients with severe bioprosthetic aortic stenosis undergoing redo aortic valve replacement. Circulation. Cardiovascular Imaging. 2017;**10**:1-10

[39] Lisi M, Henein MY, Cameli M, et al. Severity of aortic stenosis predicts early post-operative normalization of left atrial size and function detected by myocardial strain. International Journal of Cardiology. 2013;**167**:1450-1455

[40] Cameli M, Lisi M, Reccia R, et al. Pre-operative left atrial strain predicts post-operative atrial fibrillation in patients undergoing aortic valve

**59**

*Clinical Applications of Strain Imaging in Aortic Valve Disease*

of left ventricular global longitudinal strain in asymptomatic patients with significant chronic aortic regurgitation and preserved left ventricular ejection fraction. JACC: Cardiovascular Imaging.

[48] Alashi A, Khullar T, Mentias A, et al. Long-term outcomes after aortic valve surgery in patients with asymptomatic chronic aortic regurgitation and preserved LVEF: Impact of baseline and follow-up global longitudinal strain. JACC: Cardiovascular Imaging. 2020;**13**:12-21

[49] Gorgulu S, Norgaz T, Nurkalem Z, et al. Comparison of left ventricular contractility in pressure and volume overload: A strain rate study in the clinical model of aortic stenosis and regurgitation. Echocardiography.

[50] Broch K, de Marchi SF, Massey R, et al. Left ventricular contraction pattern in chronic aortic regurgitation and preserved ejection fraction: Simultaneous stress-strain analysis by three-dimensional echocardiography. Journal of the American Society of Echocardiography. 2017;**30**:422-430 e2

[51] Levy-Neuman S, Meledin V, Gandelman G, et al. The association between longitudinal strain at rest and stress and outcome in asymptomatic patients with moderate and severe aortic stenosis. Journal of the American

Society of Echocardiography.

[52] Dahl JS, Barros-Gomes S,

Videbaek L, et al. Early diastolic strain rate in relation to systolic and diastolic function and prognosis in aortic

stenosis. JACC: Cardiovascular Imaging.

2019;**32**:722-729

2016;**9**:519-528

2018;**11**:673-682

2010;**27**:798-802

*DOI: http://dx.doi.org/10.5772/intechopen.93341*

replacement for aortic stenosis. The International Journal of Cardiovascular

[41] Gelsomino S, Luca F, Parise O, et al. Longitudinal strain predicts left ventricular mass regression after aortic valve replacement for severe aortic stenosis and preserved left ventricular function. Heart and Vessels.

[42] Marciniak A, Sutherland GR, Marciniak M, Claus P, Bijnens B, Jahangiri M. Myocardial deformation abnormalities in patients with aortic regurgitation: A strain rate imaging study. European Journal of Echocardiography. 2009;**10**:112-119

[43] Smedsrud MK, Pettersen E, Gjesdal O, et al. Detection of left ventricular dysfunction by global longitudinal systolic strain in patients with chronic aortic regurgitation. Journal of the American Society of Echocardiography. 2011;**24**:1253-1259

[44] Di Salvo G, Rea A, Mormile A, et al. Usefulness of bidimensional strain imaging for predicting outcome in asymptomatic patients aged </= 16 years with isolated moderate to severe aortic regurgitation. The American Journal of

Cardiology. 2012;**110**:1051-1055

strain imaging and transmural myocardial strain profile. European Heart Journal Cardiovascular Imaging.

[46] Park SH, Yang YA, Kim KY, et al. Left ventricular strain as predictor of chronic aortic regurgitation. Journal of Cardiovascular Ultrasound.

[47] Alashi A, Mentias A, Abdallah A, et al. Incremental prognostic utility

2013;**14**:339-346

2015;**23**:78-85

[45] Kaneko A, Tanaka H, Onishi T, et al. Subendocardial dysfunction in patients with chronic severe aortic regurgitation and preserved ejection fraction detected with speckle-tracking

Imaging. 2014;**30**:279-286

2013;**28**:775-784
