**Figure 5.**

*Cardiac Diseases - Novel Aspects of Cardiac Risk, Cardiorenal Pathology and Cardiac Interventions*

genotype, which was associated with elevated levels of glycated hemoglobin and with a high concentration of LDL cholesterol and fibrinogen and with multivessel atherosclerosis, while the other genotypes of PAI-1 were not correlated with these

direct correlation with the inflammatory parameters – **Figure 5**.

In our studied group, 65% of patients had the PAI-1 4G/4G genotype, while 15% of patients had a heterozygote 4G/5G genotype. Not only did PAI-1 4G/4G genotype associate more frequently with atherogenic dyslipidemia, but it also showed a slight

As a consequence we can assume that the prothrombotic status found in patients with myocardial infarction seems to be modulated by the genomic polymorphism of clotting factor XIII, which is responsible for the formation of a more stable cruoric thrombus which is more resistant to fibrinolysis. Even more, these patients show a deficiency of the endogenous fibrinolysis, which predisposes the development of a thrombophilic status. This decrease in the thrombolytic process seems to derive from the genomic polymorphism of plasminogen activator inhibitor type 1. The most common genotype of PAI-1 associated with an increased cardiovascular risk is PAI-1 4G genotype. These polymorphisms are correlated with the presence of metabolic disorders and an abnormal inflammatory process in patients with acute coronary syndrome, thereby inducing an increased cardiovascular risk in

**8**

**Figure 4.**

**Figure 3.**

these patients.

changes – **Figures 3** and **4**.

*The relationship between PAI-1 polymorphism and the plasmatic level of fibrinogen.*

*The relationship between PAI-1 polymorphism and the plasmatic level of LDL-cholesterol.*

*Identification of PAI-1 polymorphism.*

In conclusion, a better understanding of the inflammatory and thrombotic processes that lead to myocardial infarction can help improve the manner of treatment for this patients, thus increasing their quality of life and their prognostic.
