**Chapter 7 117**

Clinical Validation of a Whole Exome Sequencing Pipeline *by Debra O. Prosser, Indu Raja, Kelly Kolkiewicz, Antonio Milano and Donald Roy Love*

#### **Chapter 8 131**

Integrating Evolutionary Genetics to Medical Genomics: Evolutionary Approaches to Investigate Disease-Causing Variants *by Ugur Sezerman, Tugce Bozkurt and Fatma Sadife Isleyen*

Preface

Understanding disease pathology and physiological pathways depends on research that examines how certain genes become abnormal. Disease processes with personal patterns can be elucidated through molecular medicine. The crux of the cure lies in precise detection and predisposition of the disease. Revealing molecular mechanisms helps create an effective personalized treatment and minimize side effects. Treatment risk and response to therapy prediction can be forecasted through early diagnosis, which improves prognosis reliability, and the effectiveness of therapies. Using this concept, monitoring health is a way to both make predictions and devise prevention. This book covers contemporary advances in molecular markers,

disease-causing variants, retroelements, and the basis of distinct diseases.

**Dr. Yusuf TUTAR**

University of Health Sciences,

Professor,

Turkey
