**9. Conclusion**

It is very clear that bacterium including *Staphylococcus aureus* shows extraordinary adaptability to cope with antibiotic effect and emerge drug resistance against antibiotics. The phenomenon of drug resistance was first observed when β-lactam antibiotics became ineffective after indiscriminative uses and plasmidresponsive β-lactamase (penicillinase) synthesis. The second wave of resistance against methicillin has been primarily contributed by the stable integration of a *mecA* gene-encoded penicillin-binding protein and penicillin-binding protein 2a or 2′ (PBP2a or PBP2′) into the staphylococcal chromosomal cassette (SCC*mec*) element. Cephalosporins have been proven as an effective drug preventing MRSA infections but failed. In progression to antibiotics, carbapenems have been used for preventing *S. aureus* infections, but multidrug resistance (MDR) strains developed. The common cause of bacterial resistance involves horizontal gene transfer, target alteration by point mutations, and expression of efflux pump, which made a variety of antibiotics ineffective and induces persistent infections in both hospital and community settings. Moreover, the prolonged and widespread use of different antibiotics, lack of awareness, and insanitation, primarily contribute in rapidly developing multiple drug resistance (MDR) in developing countries that causes a major financial burden in the treatment of infectious diseases. Though a lot of toiling is involved in devising an effective treatment against staphylococcal infections particularly for the elimination of MRSA and VRSA, the new search of bioactive molecules and their judicious use may be proven significantly to prevent the problem of drug resistance.
