*2.7.2 Mechanism of resistance*

Mupirocin-resistant (mupR) *S. aureus* was first reported in the United Kingdom in 1987.

Mupirocin resistance is classified into two types.

	- 1.Acquiring an alternate isoleucine tRNA synthetase i.e. by acquisition of a plasmid mediated mupA or isleS2 gene.
	- 2.Acquisition of mupB gene [58, 59].
