**7.8 Vaccination**

Staphylococcal bacterins [81, 94], strain 115 [95], aerosol vaccine S. epidermidis 115 [71, 95–98] and PNSG are available with an aim to prevent the Staphylococcal infections. The capsule of live or dead cells of the Smith diffuse strain of S. aureus is most antigenic and was proved and used as the earliest potent vaccinal candidate, as the antibodies produced against the capsule can deal with the strategy of this bacteria of dodging the phagocytosis [13–19]. The single intraperitoneal injection can protect from the challenge of a lethal dose of 108 CFU [26–27]. Anti-microcapsule vaccines are not proved to be as effective as capsular candidates. Bivalent vaccines are also been approved to be the effective ones. The capsule requires a monophosphoryl lipid A as adjuvant and a booster dose to show an optimal antibody response [98–102].
