**10. Conclusion**

*Staphylococcus aureus* has vital importance in the ruminants, as it is one of the major causes of Mastitis. Along with that, it also affects the health of animals, Pets, and Poultry in several ways as the diseases of bones in poultry. The Regulation of Virulence in the Staphylococci mainly are the exoproteins and surface proteins, and capsule, agr, sar 16 loci, and Alpha toxin. Bacteria potentiates cytokines for host resistance [97–101]. IFN-g and TNF play a protective role against Listeria monocytogenes, Mycobacterium species, Salmonella typhimurium, and Francisella tularensis. IFN-g and TNF also mediate gram-negative septic shock and endotoxin shock. Staphylococci induce TNF, interleukin-1, IFN-g, IL-2, and IL-6 in humans and animals [101, 102].
