**Abstract**

Staphylococcus is an adaptable pathogen and leads to rapid development of antibiotic resistance. The major targets for antibiotics are (i) the cell wall, (ii) the ribosome and (iii) nucleic acids. Resistance can either develop intrinsically or extrinsically via horizontal gene transfer, drug site modification, and efflux pumps etc. This review focuses on development of resistance to currently used antibiotics in Staphylococcal infection, novel therapeutic approaches resistance pattern of antibiotics and also the future prospectus for new antibiotics usage.

**Keywords:** Staphylococcus aureus, MRSA, antibiotic resistant
