**2.1 Overview of multi-drug resistance**

Multi-Drug Resistance (MDR) is a global concern that is having a very bad impact on health care. Microbes are getting resistant to antibiotic therapies due to the constant exposure of antimicrobial drugs. In the past decade, microbial infections have raised enormously and this has led to an increased amount of resistance [1]. Multi drug resistance is the phenomenon in which pathogenic organisms are resistant to multiple chemotherapeutic agents [2]. The emergence of MDR rises the mortality and morbidity rates for which they are known as 'Superbugs'. It is said that MDR is a very natural process among microorganisms but the increasing amount of this process is due to several reasons like the use of undefined antimicrobial agents, unhygienic sanitary conditions, poor health care facilities. The omnipresent threat of antibiotic-resistant pathogens entails having very few antimicrobial agents for other infections [2, 3].
