**5. Conclusion**

The rapid evolution of resistance in *Staphylococcus aureus* toward almost every antibiotic makes it a most challenging threat for human health as well as for the microbiology scientists. This bacteraemia has been reported to possess resistance mechanisms on the exposure of antibiotics only. Staphylococcus aureus quickly develop the defense/survival mechanism for even the new antibiotics which probably due to their fast structural and genetical alterations. Keeping this in view, several novel compounds are in pipeline to combat the resistant strains of *Staphylococcus aureus*. Moreover, identification of additional drug targets, better stewardship and combination therapies are also in process for the treatment of resistant strains of *Staphylococcus aureus*.
