**Abstract**

The most important microbe in humans is *Staphylococcus aureus*, which has caused worldwide dispersion in both nosocomial and community settings. The impact of Gram-positive *Staphylococcus Aureus* on the host is extremely detrimental to illness development. The life form is noteworthy for its ability to receive anti-toxin protection from a variety of anti-toxin classes. The development and distribution of methicillin-resistant *Staphylococcus Aureus* (MRSA) strains, which are generally multi-drug resistant in clinics and, as a result, in the population, cause severe mortality and bleakness. The research of MRSA illness transmission has advanced since its underlying event, which necessitates a complete clinical approach to dealing with take on this microorganism. For long term use drug of choice is vancomycine nevertheless its efficacy has been put to the test by rise in opposition. More modern anti-MRSA anti-infection medicines have been approved for clinical usage in the last 10 years or so. The aim of this chapter is to offer related data on the genus Staphylococcus and the evolution of antibiotic resistance in addition a discussion of the most important antibiotic resistance mechanisms. Although they are notorious for causing anti-infection blockage, there is a constant need for exploring innovative MRSA antagonists from various sources, including plants, and assessing non-anti-toxin draws close.

**Keywords:** antibiotics, staphylococci, MRSA, environment, livestock infection
