*2.8.2 Mechanism of resistance*

Two major Fusidic acid resistance mechanisms are discovered in *S. aureus*:

1.Alteration of the drug target site which is due to the mutations in fusA gene (encoding elongation factor G, EF-G), rplF or fusE (encoding ribosome protein L6)

2.Point mutation in fusA gene occurs in domain III of EF-G.

Other resistant mechanisms include:

