*2.7.1 Mechanism of action*

Mupirocin is a mixture of several pseudomonic acids. It binds to its target site of the enzyme isoleucyl-tRNA synthetase and inhibits protein synthesis. However it does not bind to the mammalian enzyme counterparts, making it non-toxic for human beings. The synthesis of bacterial isoleucine tRNA gets depleted which leads to cessation of protein and RNA synthesis in the bacteria. At the concentrations near Minimum Inhibitory Concentration (MIC) Mupirocin is bacteriostatic and at higher concentrations it becomes bactericidal. It is mainly used against the gram positive bacteria [57].
