**3. Conclusions**

MRSA represents a global threat due to its progressive resistance to antimicrobials, as well as the future prospect of no effective antibiotics. The use of lytic bacteriophages and their by-products are promising alternatives for bacterial control, since they infect and lyse the pathogen without the inconvenience of side effects, as well as contributing to lower consumption of antimicrobials, reflecting in the reduction of antibiotic resistance rates. The study of phages has always occurred in countries such as Georgia and Russia, where phage-based commercial products are relevant antibacterial alternatives. Although different *in vivo* studies have already evidenced the efficacy of phage therapy in prophylaxis and treatment of staphylococcal infections, including those caused by MRSA, some aspects should be considered before its clinical use. Among them, the restriction and scarcity of clinical trials along with the lack of robust randomized clinical trials evaluating the safety and efficacy of phage therapy are important limitations for the therapeutic use of these viruses. We highlight the need to foster studies in the area of phage therapy, especially given the scenario of increasing multi-resistant bacteria worldwide and the scarcity of new antimicrobial drugs.
