**18. Problems related to the emergence of MDR related abscesses and related clinical management issues**

Experimental methods are used to treat a range of cysts surgical treatments and antimicrobial support. However, high resistance of microorganisms to the antibiotics [96]. Resistant organisms medicines in particular, may complicate the treatment of cSSTI. Between the organisms of multi-drug resistance, MRSA, enterococci resistant to vancomycin (VRE), and gentle stretching act-lactamase (ESBL)—producing isolates of *E. coli* and *Klebsiella* spp. It has the highest incidence of [97]. Strains of CA-MRSA differ genetically apparently from HA-MRSA, and thus involve the risk of more severe infections and ease of transmission of resistance [98].

The presence of Pantone assumed—Valentin Okosidin, Botulinum cellular genes coding in MRSA isolated from infection CA—skin to play an important role in this increased virulence strains associated with tissue necrosis, and necrosis of the severity of the largest local and systemic manifestations [99]. Carrying strains of CA-MRSA is also the genes of chromosome mec (SCCmec) *Staphylococcus aureus* (types IV and V), which gives resistance to methicillin and antimicrobial agents β currently available and help in the transfer of resistance easily between living organisms. Although MRSA infection was considered, HA mainly, recent evidence has appeared on the emergence of CA-MRSA rapid even in hospitals [100].

#### **19. Surgical methods and supportive care**

The secretions of fluid from the abscess and ulcers are the common features of bacterial abscesses. Therefore, aggressive surgical revision dead tissue/infected by using chemical or mechanical methods of preferred whenever possible to stop the spread of infection and promote wound healing. The delay is known in the final revision of the soft tissue infections is considered one of the most important risk

factor for death [101]. Implementation of incision and drainage of inflammatory cysts and purulent [102]. Other roads dressing negative pressure, chronic infection or localized large wounds with excessive secretion [103]. Download closure with the help of the vacuum (as a substitute for wound healing), especially for surgical wounds or subsequent surgery deep infections, infections of the blood clotting involving venous blood clots, and vascular compensation cases involving injuries in the vascular arteries. Supportive care, which includes fluid resuscitation, and members of the support, nutritional, and management to maintain oxygen and tissue perfusion important interventions in the clinical outcomes of these patients are considered [104].
