*Pathophysiological Changes and Systemic Inflammation in Brain Dead Organ Donors… DOI: http://dx.doi.org/10.5772/intechopen.94360*

donor rat pre-treatment with anti-FB preserved renal function reduced renal damage and inflammation prior to transplantation. Seemingly, high-dose C1-INH treatment of brain-dead rat donors resulted in significantly lower renal gene expression and serum levels of IL-6, which reflected with improved renal function and reduced renal injury [51].

Traumatic brain injury and other inflammatory conditions are currently being treated in preclinical and clinical trials by a number of cellular therapies, among which mesenchymal stem cells (MSC) are of greatest interest due to their widespread usage and ease to isolate and culture [52, 53].

Therefore, strategies targeting cytokine and complement activation in human brain-dead donors pose as a new and promising opportunity to improve organ quantity and quality for successful organ donation and transplantation outcome.
