**3. Strategies to maintain pathophysiological changes in organ donors**

The current recommendations and guidelines for the management of a potential organ donor in the intensive care unit (ICU) are based on pathophysiological reasoning and experience gained from general ICU management strategies, and not on evidence from randomized controlled trials (**Table 1**) [17]. The protection and optimization of organ functions in order to provide for a maximum number of quality organs that can be offered for donation is the essential goal of intensive care donor management. The purpose of this paper is not to describe the management of the donor in detail, as this was already summarized recently by Meyfroidt et al. [18]. A more simplified and easy-to-remember series of goals was established a decade ago, known as the "rule of 100": systolic arterial pressure > 100 mmHg, urine output >100 ml/hr., arterial partial pressure of oxygen (PaO2) >100 mmHg, hemoglobin concentration > 100 g/L, and blood sugar 100% normal [15].
