**5. Conclusions**

To sum up, it is of great significance to explore the way of cell transplantation, find a treatment method that can replace the lost neurons, repair the damaged nervous system, increase the secretion of inhibitory neurotransmitter, and effectively control the occurrence and development of epilepsy. At the same time, the method can overcome the shortcomings of drug treatment and surgical treatment, fundamentally cure epilepsy. MSC and Progenitors/Stem cell derived from multiple sources can reduce epileptogenesis and improved cognitive function with grafting performed to epileptic brain regions. This has been demonstrated in animal prototypes of chronic TLE, kindling, SE and absence seizures, and in mutant mice displaying SRS. These abundant studies have laid a solid foundation for the early application of cell transplantation therapy in clinical practice.
