**1. Introduction**

Depakin is an anticonvulsant drug (AED) [1, 2] according to the International League Against Epilepsy (ILAE) recommendations [3, 4]. Depakin increases the GABA-ergic inhibition in the neuronal networks of the CNS [5]. VPA derivative depakine (Dep) [6] exerts a combined influence on the brain's neurons. It increases the GABA content through GABA transfers inhibition, reducing the reuptake of GABA in the brain tissue and activating the GABA receptors. [5].

The EEG study during Dep treatment depends on the form of epilepsy [7]. EEG investigation in pediatric population during Dep treatment should be considered as a better approach [8–10] as brain malination is not completed [11–13]. Moreover, nowadays no data base analysis is done to study the correlation between EEG and AED treatment [14]. Another problem is that there are more data on the EEG morphology compared to the quantitative EEG analysis [15–18].

A quantitative analysis of the EEG should reflect the effectiveness of the AED treatment since the EEG disorders are connected with clinical exacerbation [14, 19–21]. Thus, this work's purpose is to investigate the alteration of EEG in epileptic children during AED treatment.
