**2.3 Clinical course or trajectories and complications**

In a recent study using incident cohort of drug resistant epilepsy, which adopt ILAE DRE criteria, there are different patterns of disease progression or trajectories observed [14]. The 30% proportion of patient eventually suffered from DRE was again observed. A long delay from disease onset to failure of second AED was also found. This finding might give insights to the pathogenesis as mentioned earlier.

The mortality and morbidity of DRE, is in general, believed to be higher than that of seizure free patients or patient with good seizure control [15–17]. Even in those that suffered from infrequent seizure, their daily life and subjective wellbeing are also jeopardized in various extents [18].
