**3. Diabetic autonomic neuropathy**

DAN is quite common, yet remained mostly undiagnosed and micro-vascular complications of T2DM are affecting many organ systems (gastrointestinal, genitourinary, cardiovascular) of the body [7]. However, CAN is clinically the most important form of DAN as it is associated with life-threatening complications (arrhythmias, silent MI) and sudden death [9]. The underlying pathophysiology of DAN is still unclear; however, it has been attributed to chronic hyperglycemia induced oxidative stress and inflammation with subsequent neuronal injury and death [9, 16–19].
