**4. Conclusions and future direction**

As a summary, this chapter has explained on the relationship of food intake pathway and adipocytokine hormone effecting CVD in MetS. Adiponectin and resistin were found to have good correlation in the condition of high fat intake. High fat intake such as saturated fat and LDL food sources would potentially induce the level of resistin while polyunsaturated fatty acids and HDL food type potentially increase the level of adiponectin. High level of resistin and low level of adiponectin would contribute to the cardiovascular disease via AMPK and TLR4 pathways, respectively.

There were many studies done in investigating the action of adiponectine and resistin related to MetS and suggested various signaling pathways and mechanisms supporting effect of both protein hormones on CVD. Study believes that food intake would play a huge role in adjusting the level of adiponectin and resistin at various levels such as gene modification. Therefore, there is a scope for future studies to investigate narrowly on the mechanisms affecting adiponectin and resistin single nucleotide polymorphisms (SNPs) towards the development of Mets at cellular level.
