**Abstract**

Dietary and exercise interventions are the mainstay of prevention, and they constitute important part in the treatment of type 2 diabetes (DM2) and its complications. Automated, continuous, individualized non-invasive measurement of pathological processes leading to DM2 and complications are needed in terms of self-explaining metrics for improved individualized lifestyle management. Our company, the Ori Diagnostic Instruments, LLC is using tools of Medical Cybernetics (MC) to monitor non-invasive indicators of insulin resistance, exercise capacity, and autonomic dysfunction. The MC approach utilizes mathematical process and measurement models which are connected to a wearable sensor system. This chapter has the purpose to show how already widely available information technologies like smart phones, cloud computing, and sensor devices of the fitness industry could be put together into an integrated cyber-physical system (ICPS) to support fitness goals like fighting cardiometabolic conditions including high insulin resistance and low level of cardiorespiratory fitness and help building resilience with improved physiological reserve capacity. We want to demonstrate also how ICPS can be not only used for fitness self-management but can be extended to become a platform of noninvasive monitoring devices and become a medical software to support person-centered, outcome driven treatments for DM2 and complications in primary care.

**Keywords:** medical cybernetics, non-invasive monitoring, insulin resistance, exercise capacity, cardiorespiratory fitness, cardio-vegetative stress, metabolic syndrome, atherosclerotic disease, autonomic dysfunction, anemia, heart failure
