**Dedication**

Taking into account the dawning observations of Paul Langerhans (1847–1888) [102], Oskar Minkowski (1858–1931) [103], George Ludwig Zülzer (1870–1949) [104], Ernest Lyman Scott (1877–1966) [105] and others in [106, 107], this paper was written in the memory of Nicolae Constantin Paulescu (1869–1931), James Bertram Collip (1892–1965), Frederick Grant Banting (1891–1941), Charles Herbert Best (1899–1978) and John James Rickard Macleod (1876–1935) on the occasion of the 100 year anniversary of insulin (pancrein) discovery (Bucharest, May 1921) [4], and its purification and implementation to human medicine (Toronto, January 1922) [5].

**23**

**Author details**

Rudolf Chlup1,2\*, Richard Kaňa3

and Blanka Doubravová3

Olomouc, Czech Republic

Paseka, Czech Republic

*Pathophysiologic Approach to Type 2 Diabetes Management: One Centre Experience 1980–2020*

, Lada Hanáčková<sup>3</sup>

1 Department of Physiology, Faculty of Medicine and Dentistry, Palacky University

2 2nd Department of Medicine, Teaching Hospital Olomouc, Czech Republic

\*Address all correspondence to: rudolf.chlup@fnol.cz

provided the original work is properly cited.

3 Department of Diabetes Moravský Beroun, Institute of Specialized Treatments,

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

, Hana Zálešáková<sup>3</sup>

*DOI: http://dx.doi.org/10.5772/intechopen.96237*

*Pathophysiologic Approach to Type 2 Diabetes Management: One Centre Experience 1980–2020 DOI: http://dx.doi.org/10.5772/intechopen.96237*
