**Author details**

*Type 2 Diabetes - From Pathophysiology to Cyber Systems*

neverending support.

**Dedication**

performance of therapeutic protocols including HbA1c and 10-point glycaemic profiles, H.Z. was responsible for medical reports, files and IT operations, B.D. took

Ferancová, Pavel Kolčava, Eva Malá, Dana Masnikosová, Hana Peniaková, Jiří Podivínský, Jana Svobodová, Rastislav Šramko and their teams for outstanding

of Palacky University Olomouc, compliant persons with diabetes, as well as to

Those who found this chapter worthy of reading surely appreciate the support provided by Palacky University, Teaching Hospital Olomouc, Institute of

Taking into account the dawning observations of Paul Langerhans (1847–1888) [102], Oskar Minkowski (1858–1931) [103], George Ludwig Zülzer (1870–1949) [104], Ernest Lyman Scott (1877–1966) [105] and others in [106, 107], this paper was written in the memory of Nicolae Constantin Paulescu (1869–1931), James Bertram Collip (1892–1965), Frederick Grant Banting (1891–1941), Charles Herbert Best (1899–1978) and John James Rickard Macleod (1876–1935) on the occasion of the 100 year anniversary of insulin (pancrein) discovery (Bucharest, May 1921) [4], and its purification and implementation to human medicine (Toronto, January 1922) [5].

Special thanks to Stanislava Dudová, Emilia Ďurajková, Lenka Kratochvílová,

Final acknowledgement belongs to specialists, nursing and other staff, students

care of laboratory investigations. There is no conflict of interests.

Michaela Nádvorniková, Jana Polcerová, Svatava Tancosová, Jana

Insurance Companies and pharma industry in the Czech Republic.

Specialized Treatments Paseka and other important institutions.

**22**

Rudolf Chlup1,2\*, Richard Kaňa3 , Lada Hanáčková<sup>3</sup> , Hana Zálešáková<sup>3</sup> and Blanka Doubravová3

1 Department of Physiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic

2 2nd Department of Medicine, Teaching Hospital Olomouc, Czech Republic

3 Department of Diabetes Moravský Beroun, Institute of Specialized Treatments, Paseka, Czech Republic

\*Address all correspondence to: rudolf.chlup@fnol.cz

© 2021 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
