*3.4.2 Therapeutic management of DFUs: main principles*

Management of DFUs is aimed at correcting the pathogenic triad of neuropathy, PAD and infection. Off-loading with appropriate footwear and/or casts, debridement of callus and/or necrotic tissue, revascularization (by-pass grafting or intraluminal angioplasty) and infection control are the top priorities [86, 96, 97]. These may be aided by special dressings, skin substitutes, growth factors and other modalities [111–116]. Special care must be taken to recognize and promptly deal with emergencies requiring surgery and other urgent interventions [117].
