Meet the editor

Pier Paolo Piccaluga, Prof., MD, Ph.D., is currently Associate Professor of Pathology at the Department of Experimental, Diagnostic and Specialty Medicine, Bologna University School of Medicine—Institute of Hematology and Medical Oncology, and has been responsible for many years for the Molecular Pathology Laboratory. In 2018, he was appointed for teaching at the Queen Mary University of London and Jomo Kenyatta University of Ag-

riculture and Technology, Nairobi, Kenya. He is the author of several international publications in journals such as Nature Medicine, Journal of Clinical Investigation, Journal of Experimental Medicine, Journal of Clinical Oncology, Blood, Lancet Oncology, and Lancet Infectious Diseases. Dr. Piccaluga is ranked a Top Italian Scientist (TIS) by VIA-Academy.

Contents

**Section 1**

**Section 2**

Leukemia

of Acute Leukemias

*and Jenny Y. Wang*

*by Pier Paolo Piccaluga*

*by Ashraf Abdullah Saad*

**Preface XI**

Introduction **1**

**Chapter 1 3**

Biology and Diagnosis of Acute Leukemias **11**

**Chapter 2 13**

**Chapter 3 35**

**Chapter 4 57** The Key Role of the Phosphatase PP2A in the Development of Acute Myeloid

**Chapter 5 75**

**Chapter 6 97**

**Chapter 7 109**

Reactive Oxygen Species and Metabolic Re-Wiring in Acute Leukemias

Melanin, from an Evolutionary Remnant to the Myeloid Lineage Cell's Main Energy Source. The Unsuspected Intrinsic Property of Melanin to Dissociate the Molecule from Water. Possible Implications in the Context

*by Jonason Yang, Nunki Hassan, Sheng Xiang Franklin Chen, Jayvee Datuin* 

Introductory Chapter: A Brief History of Acute Leukemias Treatment

Juvenile Myelomonocytic Leukemia (JMML): A Mimicker of *KMT2A*-Rearranged Acute Myeloid Leukemia (AML)

*by Andrew J. Robinson, Richard L. Darley and Alex Tonks*

*by Javier Marco, Irene Peris, Carmen Vicente and Elena Arriazu*

*by Arturo Solís Herrera, Ruth I. Solís Arias and Luis F. Torres Solís*

Self-Renewal Pathways in Acute Myeloid Leukemia Stem Cells

MicroRNAs and Their Role in Acute Lymphoblastic Leukemia *by Edgardo Becerra Becerra and Guadalupe García-Alcocer*
