**Chapter 7**

*Acute Leukemias*

2007;282(21):15903-11.

Biol Cell. 2008;19(6):2588-96.

[52] Bendell J, Eckhardt GS,

2016;69:S29-S30.

[51] Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N,

Augustin HG, et al. The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 2008;135(22):3655-64.

Hochster HS, Morris VK, Strickler J, Kapoun AM, et al. Initial results from a phase 1a/b study of OMP-131R10, a first-in-class anti-RSPO3 antibody, in advanced solid tumors and previously treated metastatic colorectal cancer (CRC). European Journal of Cancer.

is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling. J Biol Chem.

[50] Kim KA, Wagle M, Tran K, Zhan X, Dixon MA, Liu S, et al. R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol

**108**
