**1.6 E-selectin inhibitors**

The endothelial cell adhesion molecule E-selectin is a key component of the bone marrow hematopoietic stem cell (HSC) vascular niche regulating balance between HSC self-renewal and commitment. E-selectin is expressed transiently in the normal vasculature during an inflammatory response and constitutively in the bone marrow. E-selectin directly triggers signaling pathways that promote malignant cell survival and regeneration. In vivo AML blasts with highest E-selectin binding potential are 12-fold more likely to survive chemotherapy and main contributors to disease relapse [99, 100].
