**Chapter 7**

*Recent Advances in Bone Tumours and Osteoarthritis*

study. Osteoarthritis and Cartilage.

[25] Brosseau L, Taki J, Desjardins B, et al. The Ottawa panel clinical practice

[26] Kang Y-H et al. Natural products as sources of novel drug candidates for the pharmacological management of osteoarthritis: A narrative review. Biomolecules & Therapeutics.

[27] Gersing A, Schwaiger B, Nevitt M, et al. Is weight loss associated with less progression of changes in knee articular cartilage among obese and overweight patients as assessed with MR imaging over 48 months? Data from the osteoarthritis initiative. Radiología.

[28] Volkow N, McLellan A. Opioid abuse in chronic pain-misconceptions

[29] DeMik D, Bedard N, Dowdle S, et al. Are we still prescribing opioids for osteoarthritis? The Journal of Arthroplasty. 2017;**S0883-5403**(17):30666

and mitigation strategies. The New England Journal of Medicine.

2016;**374**(13):1253-1263

guidelines for the management of knee osteoarthritis. Part one: Introduction, and mind-body exercise programs. Clinical Rehabilitation.

2017;**25**:839-845

2017;**31**(5):582-595

2019;**27**(6):503-513

2017;**284**(2):508-520

osteoarthritis: Outcomes of a systematic review and meta-analysis. Drugs & Aging. 2019;**36**(Suppl 1):S65-S99

[18] Pavelka K, Bruyere O, Cooper C, Kanis JA, Leeb BF, Maheu E, et al. Diacerein: Benefits, risks and place in the management of osteoarthritis. An opinion-based report from the ESCEO. Drugs & Aging. 2016;**33**(2):75-85

[19] Delbarre A, Amor B, Bardoulat I, Tetafort A, Pelletier-Fleury N. Do intraarticular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis—A cox model analysis. PLoS One. 2017;**12**(11):e0187227

[20] Bannuru RR, Osani M, Vaysbrot EE, McAlindon TE. Comparative safety profile of hyaluronic acid products for knee osteoarthritis: A systematic review and network meta-analysis. Osteoarthritis and Cartilage. 2016;**24**(12):2022-2041

[21] Strand V, McIntyre LF, Beach WR, Miller LE, Block JE. Safety and efficacy of US-approved viscosupplements for knee osteoarthritis: A systematic review and meta-analysis of randomized, saline-controlled trials. Journal of Pain

[22] Bartels EM, Juhl CB, Christensen R, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane

Database of Systematic Reviews.

[23] Goh S-L et al. Relative efficacy of different exercises for pain, function, performance and quality of life in knee and hip osteoarthritis: Systematic review and network meta-analysis. Sports Medicine. 2019;**49**:743-761

[24] Wink AE, Gross KD, Brown CA, et al. Varus thrust during walking and the risk of incident and worsening medial tibiofemoral MRI lesions: The multicenter osteoarthritis

Research. 2015;**8**:217-228

2016;**3**:CD005523

**106**
