Lipids Abnormality and Type 2 Diabetes Mellitus: Causes and Consequences

*Kan Wang and Fariba Ahmadizar*

## **Abstract**

Dyslipidemia and diabetes both are important risk factors for cardiovascular disease. Emerging evidence suggests that these two are closely related to each other, the so-called "dyslipidemia-insulin resistance-hyperinsulinemia" cycle. Recently, several new lipid subfractions, such as apolipoprotein (Apo)B, and ApoJ, have been reported to associate with insulin resistance and incident diabetes, which further claim the role of lipid in the pathophysiology of diabetes. Besides, dyslipidemia is also one of the most prevalent diabetic complications. Clinical guidelines have widely recommended lipid management among diabetic patients through lifestyle intervention and lipid-lowering medications, especially statins, to prevent cardiovascular outcomes.

**Keywords:** Lipid, dyslipidemia, diabetes, cardiovascular disease, statins
