**Acknowledgements**

We thank all the patients in this work, Prof. Houxuan Li and Dr. Juan Liu from department of periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University. This work was supported in part by the Nanjing Medical Science and Technology Development Program (YKK18121 to JW), the Natural Science Foundation of Jiangsu Province (BK20200149 to JW), and the Health and Medical Research Fund, Hong Kong Special Administrative Region, China (02132216 to WKL).
