**6. Future perspectives**

At least 50% of periodontitis vulnerability is attributed to heredity or genetic factors [20]. Clinical observations and scientific studies have demonstrated that the heredity of a host response pattern may be an important susceptibility factor in developing periodontal diseases [20, 79, 80]. Added information from new technologies, such as micro-arrays and DNA-sequencing, lead to the identification of specific genetic, environmental, and behavioural factors that influence periodontitis susceptibility [81].

In order to enhance the therapeutic management of periodontal disease, we must not only be able to identify genetic determinants, but also learn to modify, control or modulate the host response either by stimulating a desired immune response, or by decreasing the activating factors of bone resorption,both of which hinders the progression of the disease by [82–84].
