**5. Conclusions**

Glucose, as the main source of energy for the cells of the human body, is regulated by the joint work of several organs. Each organ involved in this glucose regulatory mechanism plays an important role that cannot be disregarded. Metabolic disorders such as diabetes mellitus are supposed to only cause an alteration of the pancreas, but recent studies indicate that when a condition such as diabetes mellitus appears, the rest of the organs are also significantly affected. For this reason, it is important to have a healthy lifestyle both to prevent diseases that cause metabolic disorders if you do not have them or to have better control of blood glucose levels and prevent possible complications that these disorders can cause.

## **Author details**

Laura Lema-Pérez National University of Colombia, Medellín, Colombia

\*Address all correspondence to: llemap@unal.edu.co

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Main Organs Involved in Glucose Metabolism DOI: http://dx.doi.org/10.5772/intechopen.94585*

[1] F. E. T. Al, C. S. Fink, P. Hamosh, and M. Hamosh, "Fat Digestion in the Stomach: Stability of Lingual Lipase in the Gastric Environment," no. 62, 1984. normoglycaemia," *Int. J. Clin. Pract. Suppl.*, vol. 159, pp. 2-7, 2008, doi: 10.1111/j.1742-1241.2007.01686.x.

"Somatostatin secreted by islet deltacells fulfills multiple roles as a paracrine regulator of islet function.," *Diabetes*, vol. 58, no. 2, pp. 403-11, 2009, doi:

[12] S. Y. Kim *et al.*, "SREBP-1c mediates

glucokinase expression," *J. Biol. Chem.*, vol. 279, no. 29, pp. 30823-30829, 2004,

[14] N. A. Syed and R. L. Khandelwal, "Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells.," *Mol. Cell. Biochem.*, vol. 211, no. 1-2, pp. 123-136, Aug. 2000, doi:

[11] A. C. Hauge-Evans *et al.*,

the insulin-dependent hepatic

doi: 10.1074/jbc.M313223200.

[13] T. B. Miller and J. Larner, "Mechanism of control of hepatic glycogenesis by insulin," *J. Biol. Chem.*, vol. 248, no. 10, pp. 3483-3488, 1973.

10.1023/a:1007159422667.

[15] M. Hao, X. Li, M. A. Rizzo, J. V Rocheleau, B. M. Dawant, and D. W. Piston, "Regulation of two insulin granule populations within the reserve pool by distinct calcium sources," *J. Cell Sci.*, vol. 118, no. 24, pp. 5873-5884, 2005, doi: 10.1242/jcs.02684.

[16] Z. Fu, E. R. Gilbert, and D. Liu, "Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes," *Curr. Diabetes Rev.*, vol. 9, no. 1, pp. 25-53, 2013, doi:

[17] A. H. Khan and J. E. Pessin, "Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways.," *Diabetologia*, vol. 45, no. 11,

10.2174/157339913804143225.

10.2337/db08-0792.

[2] K. S. Saladin, *Anatomy & Physiology: The Unity of Form and Function*, 7th Edició. McGraw-Hill Education, 2014.

[3] L. Poretsky, *Principles of Diabetes*, 2nd ed., vol. 53, no. 9. Springer, Boston,

[4] J. A. Fernandez-Tresguerres *et al.*, *Fisiología humana*, 3rd ed. 2005.

[6] P. V. Röder, B. Wu, Y. Liu, and W. Han, "Pancreatic regulation of glucose homeostasis," *Exp. Mol. Med.*, vol. 48, no. November 2015, p. e219, 2016, doi:

[7] M. Brissova *et al.*, "Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.," *J. Histochem. Cytochem. Off. J. Histochem. Soc.*, vol. 53, no. 9, pp. 1087-1097, Sep. 2005, doi: 10.1369/

[8] G. Katsuura, A. Asakawa, and A. Inui, "Roles of pancreatic polypeptide

[9] N. Wierup, H. Svensson, H. Mulder, and F. Sundler, "The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.," *Regul. Pept.*, vol. 107, no. 1-3, pp. 63-69, Jul. 2002, doi: 10.1016/ s0167-0115(02)00067-8.

[10] B. Göke, "Islet cell function: α and β cells - Partners towards

in regulation of food intake," *Peptides*, vol. 23, no. 2, pp. 323-329, 2002, doi: https://doi.org/10.1016/

S0196-9781(01)00604-0.

10.1038/emm.2016.6.

jhc.5C6684.2005.

[5] John E. Hall PhD, *Textbook of Medical Physiology*, 13th ed. Guyton Physiology,

**References**

MA, 2009.

2015.

*Main Organs Involved in Glucose Metabolism DOI: http://dx.doi.org/10.5772/intechopen.94585*
