**Chapter 9**

*Sugar Intake - Risks and Benefits and the Global Diabetes Epidemic*

and diabetic sujbjects.," *J. Clin. Invest.*, vol. 46, no. 12, pp. 1954-1962, Dec. 1967, doi: 10.1172/JCI105685.

[57] D. J. Drucker and M. A. Nauck, "The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.," *Lancet (London, England)*, vol. 368, no. 9548, pp. 1696-1705, Nov. 2006, doi: 10.1016/

[58] J. J. Holst and J. Gromada, "Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans.," *Am. J. Physiol. Endocrinol. Metab.*, vol. 287, no. 2, pp. E199-206, Aug. 2004, doi: 10.1152/

[59] C. Howarth, P. Gleeson, and D. Attwell, "Updated energy budgets for neural computation in the neocortex and cerebellum," *J. Cereb. Blood Flow Metab.*, vol. 32, no. 7, pp. 1222-1232, 2012, doi: 10.1038/jcbfm.2012.35.

[60] P. Mergenthaler, U. Lindauer, G. A. Dienel, and A. Meisel, "Sugar for the brain: the role of glucose in physiological and pathological brain function," *Trends Neurosci.*, vol. 36, no. 10, pp. 587-597, 2014, doi: 10.1016/j.

tins.2013.07.001.Sugar.

S0140-6736(06)69705-5.

ajpendo.00545.2003.

*J Physiol Endocrinol Metab*, vol. 282, pp.

[50] G. Pehling, P. Tessari, J. E. Gerich, M. W. Haymond, F. J. Service, and R. A. Rizza, "Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy," *J. Clin. Invest.*, vol. 74, no. 3, pp. 985-991, 1984, doi:

[51] G. Jiang and B. B. Zhang, "Glucagon and regulation of glucose metabolism," *Am. J. Physiol. Metab.*, vol. 284, no. 4, pp. E671–E678, 2003, doi: 10.1152/

[52] J. J. Holst, "Glucagon-like Peptide 1 (GLP-1): An Intestinal Hormone, Signalling Nutritional Abundance, with an Unusual Therapeutic Potential.," *Trends Endocrinol. Metab.*, vol. 10, no. 6, pp. 229-235, Aug. 1999, doi: 10.1016/

419-427, 2002.

10.1172/JCI111519.

ajpendo.00492.2002.

s1043-2760(99)00157-5.

physiol.59.1.243.

jcem-63-2-492.

[53] J. J. Meier, M. A. Nauck, W. E. Schmidt, and B. Gallwitz, "Gastric Inhibitory Polypeptide: the neglected incretin revisited," *Regul. Pept.*, vol. 107, no. 1, pp. 1-13, 2002, doi: https://doi. org/10.1016/S0167-0115(02)00039-3.

[54] G. Sachs, N. Zeng, and C. Prinz, "PHYSIOLOGY OF ISOLATED

[55] M. A. Nauck *et al.*, "Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses.," *J. Clin. Endocrinol. Metab.*, vol. 63, no. 2, pp. 492-498, Aug. 1986, doi: 10.1210/

[56] M. J. Perley and D. M. Kipnis, "Plasma insulin responses to oral and intravenous glucose: studies in normal

GASTRIC ENDOCRINE CELLS," *Annu. Rev. Physiol.*, vol. 59, no. 1, pp. 243- 256, Oct. 1997, doi: 10.1146/annurev.

**134**
