**1. Introduction**

Chronic pain is a public health issue, affecting nearly a quarter of our population, and takes different forms such as neuropathic, cancer-related or inflammatory pain [1]. This condition limits patients in their daily activities leading to despair and significant loss in quality of life. The most common methods of treatment include physical therapy, oral medications, injections, surgery and neuromodulation. The injectates that are the most commonly used include local anesthetics and steroids. The use of autologous biologic injectates (e.g., platelet rich plasma, bone marrow aspirate concentrate, tissue grafts, and stem cells) is growing in therapeutic potential and enthusiasm, giving hope to a subset of patients that have either failed conventional therapy or are not candidates for traditional steroid injections. Continued clinical trials are needed to further validate their use and help expand their application in the field of medicine. The theory of using these therapies for painful conditions stems from their cytoprotective properties, as well as their regenerative potential.
