**Abstract**

Medications are prescribed throughout the world for a variety of reasons including pain. NSAIDs, opioids, and other non-opioid modalities have been used to treat both acute and chronic pain. In this chapter we will discuss the pharmacokinetics, indications, function and associated complications for commonly used pain medications to include NSAIDs, opioids, antidepressants, cannabinoids, and ketamine.

**Keywords:** acute pain, chronic pain, NSAIDs, opioids, antidepressants, cannabinoids, ketamine
