Antimicrobial Activity of Essential Oils

**141**

preparation of drugs.

*Pseudomonas aeruginosa*, *Staphylococcus aureus*

**Abstract**

**Chapter 8**

Chemical Composition and

Antibacterial Activity of the

*Gledson Ferreira Macedo, Janete de Souza Bezerra,* 

*Viviane Bezerra da Silva, Isabella Hevily Silva Torquato,* 

*Niwiarakelly da Silva Monte, Luciano Temoteo dos Santos* 

*Mesosphaerum suaveolens* (Lamiaceae) is a medicinal plant commonly used in Brazil for the treatment of diseases related to the digestive tract and respiratory diseases, so we hypothesized that the essential oil of this species may have antibacterial activity. Thus, we aimed to evaluate the *in vitro* antibacterial and modulatory activity of the essential oil of *M. suaveolens* as well as to characterize its chemical composition. The identification of the constituents was performed by gas chromatography-flame ionization detector (GC-FID) and the antibacterial and modulating activity by the plate microdilution method. We found the oil had sesquiterpene β-caryophyllene as the major component. This compound may account for the antibacterial activity against *Staphylococcus aureus* strains, since the essential oil had a MIC of 64 μg/mL for the standard strain and 256 μg/mL for the multiresistant strain, demonstrated that the oil does not exhibit drug modulating activity. Thus, *M. suaveolens* oil has bioactive compounds which can be used in the

**Keywords:** bacteria, *Hyptis suaveolens*, bamburral, β-caryophyllene, *Escherichia coli*,

*suaveolens* (Lamiaceae)

*Ma Aparecida Barbosa Ferreira Gonçalo,* 

*Marcos Aurélio Figuereido dos Santos,* 

*Priscilla Augusta de Sousa Fernandes,*

*Emanoel Messias Pereira Fernando,* 

*Carlos Henrique Silva de Oliveira,* 

*and Henrique Douglas Melo Coutinho*

Essential Oil of *Mesosphaerum* 

*José Weverton Almeida Bezerra, Felicidade Caroline Rodrigues,* 

**Chapter 8**
