**4.5 Antihyperglycemic and antidiabetic activities**

Cunha et al. [74] evaluated, *in vivo*, the control of postprandial hyperglycemia by performing a test of oral glucose tolerance in normoglycemic mice. After glucose overload, the mice treated with *A. mellifera* showed, after 30 min, reduced hyperglycemia peak and blood glucose values, as well as normalization of water intake. These results are similar to that showed by metformin, a first-line medication for the treatment of type 2 diabetes. Control of postprandial hyperglycemia has been linked with reduced vascular damage in diabetic patients.
