**Author details**

*Essential Oils - Bioactive Compounds, New Perspectives and Applications*

lic acids, which was evaluated by inhibition of free radical DPPH.

**4.5 Antihyperglycemic and antidiabetic activities**

linked with reduced vascular damage in diabetic patients.

**4.4 Antioxidant activity**

**5. Conclusions**

yield and chemical composition.

(SAIC/Embrapa: 22500.18/0015-7).

**Acknowledgements**

**Conflict of interest**

publication of this paper.

coating before and after surgery. This property may be due to its hypertonicity, acceleration of epithelization, low pH, and the presence of inhibin and catalase.

In the work of Souza et al. [72], *A. mellifera* extracts, obtained by hydrodistillation, exhibited high antioxidant activity evaluated by free radical DPPH sequestration and β-carotene/linoleic acid methods. The authors linked these results to the presence of the following compounds: prenylated benzophenones, epinemorosone, xanthochymol, gambogenone, and aristophenone A. Wiwekowati et al. [73] also attributed the high antioxidant potential of *A. mellifera* to the structure of its flavonoids and pheno-

Cunha et al. [74] evaluated, *in vivo*, the control of postprandial hyperglycemia by performing a test of oral glucose tolerance in normoglycemic mice. After glucose overload, the mice treated with *A. mellifera* showed, after 30 min, reduced hyperglycemia peak and blood glucose values, as well as normalization of water intake. These results are similar to that showed by metformin, a first-line medication for the treatment of type 2 diabetes. Control of postprandial hyperglycemia has been

Propolis essential oil presents various biological properties, being active against

microorganisms such as bacteria, fungi, and viruses. It is evident that climatic factors are able to influence the chemical composition of the *Apis mellifera* propolis essential oil. In addition, the extraction technique chosen may also influence its

Jorddy Neves Cruz appreciates the support of the Eliseu Alves Foundation

The authors declare that there are no conflicts of interest regarding the

**130**

Jorddy Neves Cruz1,2\*, Adriane Gomes da Silva2 , Wanessa Almeida da Costa<sup>3</sup> , Ely Simone Cajueiro Gurgel4 , Willison Eduardo Oliveira Campos2 , Renan Campos e Silva<sup>3</sup> , Marcos Ene Chaves Oliveira<sup>2</sup> , Antônio Pedro da Silva Souza Filho2 , Daniel Santiago Pereira<sup>2</sup> , Sebastião Gomes Silva1 , Eloisa Helena de Aguiar Andrade1 and Mozaniel Santana de Oliveira1,4\*

1 Adolpho Ducke Laboratory, Emílio Goeldi Paraense Museum, Belém, PA, Brazil

2 Laboratory of Agro-Industry, Embrapa Eastern Amazon, Belém, Pará, Brazil

3 Program of Post-Graduation in Chemistry, Federal University of Para, Belém, PA, Brazil

4 Postgraduate Program in Biological Sciences - Tropical Botany, Federal Rural University of Amazonia and Emílio Goeldi Paraense Museum, Belém, PA, Brazil

\*Address all correspondence to: jorddynevescruz@gmail.com and mozaniel.oliveira@yahoo.com.br

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
