Contents

#### **Preface XIII**

#### **Part 1 Disease Etiology 1**

	- **Part 2 Microrganisms in Atopic Dermatits 105**

X Contents


Contents VII

Chapter 19 **Improvement of Atopic Dermatitis** 

Chapter 20 **Probiotics and Atopic Dermatitis 325** 

Chapter 21 **The Role of Probiotics in Atopic**

Öner Özdemir

Feriel Hacini-Rachinel, Ivana Jankovic, Anurag Singh and Annick Mercenier

**Dermatitis Prevention and Therapy 353**

**Associated with Atopic Dermatitis 387** Reuven Rasooly and Mendel Friedman

Chapter 22 **Food Compounds Inhibit** *Staphylococcus Aureus* **Bacteria** 

**and the Toxicity of Staphylococcus Enterotoxin A (SEA)** 

**by Human Sebaceous Fatty Acids and Related Lipids 309** 

Hiroyuki Araki, Yoshiya Sugai and Hirofumi Takigawa


VI Contents

Chapter 8 **Atopic Dermatitis and Skin Fungal Microorganisms 123** 

Ryoji Tsuboi, Yoshio Ishibashi, Akemi Nishikawa

Chapter 9 **Fungus as an Exacerbating Factor of Atopic Dermatitis,** 

Takuji Nakashima and Yoshimi Niwano

**Part 3 Diagnosis and Clinical Management 159** 

Nicola Fuiano and Cristoforo Incorvaia

Hong-Duo Chen and Xing-Hua Gao

Chapter 12 **Physical and Chemical Factors that Improve** 

Chapter 11 **Advances in Assessing the Severity of Atopic Dermatitis 169**

Mitsuhiro Denda

Evmorfia Ladoyanni

Chapter 14 **Food Allergy in Atopic Dermatitis 229**  Geunwoong Noh and Jae Ho Lee

Chapter 15 **Clinical Management of Atopic Dermatitis 251**

Angela Singh and Todd Woodard

Chapter 16 **Occlusive Therapy in Atopic Dermatitis 269**

Wilson Liao and John Y. M. Koo

T. Abe and O. Arisaka

Massimo Milani

Chapter 13 **Trigger Factors, Allergens**

**Part 4 New Treatments 267**

Chapter 10 **Atopic Dermatitis:** 

Takashi Sugita, Enshi Zhang, Takafumi Tanaka, Mami Tajima,

**and Control of Fungi for the Remission of the Disease 141** 

**From Pathophysiology to Diagnostic Approach 161** 

Zheng-Hong Di, Li Zhang, Ya-Ni Lv, Li-Ping Zhao,

**Epidermal Permeability Barrier Homeostasis 197** 

**and Allergy Testing in Atopic Dermatitis 213**

Soheyla Mahdavian, Patty Ghazvini, Luis Pagan,

Misha M. Heller, Eric S. Lee,Faranak Kamangar,

Chapter 17 **Suplatast Tosilate for Prophylaxis of Pediatric Atopy 289**  S. Yoshihara, M. Ono, Y. Yamada, H. Fukuda,

Chapter 18 **Thinking Atopic Dermatitis Treatment Differently: Specific Immunotherapy as an Option 299**


Preface

Atopic Dermatitis is a common disease characterized by inflamed, itching and dry skin. This relapsing allergic disorder has complex etiology and shows a remarkably high clinical heterogeneity which complicates the diagnosis and clinical management.

This book is divided into 4 sections. The first section (Disease Etiology) describes some of the physiological mechanisms underlying Atopic Dermatitis, including alterations in the immune system and the skin-barrier function. The important role of host-microorganism interactions on the pathophysiology of Atopic Dermatitis is discussed in the second section (Microorganisms in Atopic Dermatitis). An overview of the clinical diagnostic criteria and the disease management protocols commonly used is given in the third section (Diagnosis and Clinical Management). The last section (New Treatments) describes new therapeutic approaches that are not widely used but are currently being studied due to preliminary evidence showing a clinical benefit for Atopic Dermatitis.

As a co-editor, it was my greatest pleasure to work with Dr Jorge Esparza-Gordillo on this book, which handles cutting-edge ideas on atopic dermatitis, provided by ambitious specialists. Every chapter is a real pearl of the subject, and as a clinicianscientist, I was delighted to read the manuscript one by one. I believe clinicians and researchers worldwide will benefit from this book as a unique free online publication.

Thanks to Ms. Bojana Zelenika and Mr. Dejan Grgur of InTech - Open Access Publisher, this book is published with a very quick publication process, and will thus reach the reader with the latest information. Last but not least, I thank my wife Shoko

**Itaru Dekio, MD, PhD**

Japan

Shimane University, Izumo,

Department of Dermatology, Faculty of Medicine,

for her enormous support during this project.
