**Author details**

*Clinical Implementation of Bone Regeneration and Maintenance*

In this chapter, we attempted to describe the basic pathophysiology of metabolic processes at the site of orthopedic infection. Knowledge of peculiarities of such processes is important for an orthopedic surgeon because the general success of treatment relies not only on surgery and antibiotic therapy but also etiologic therapy of bone metabolism impairment. This thesis is supported not only by

*(a-c) "Box-and-whiskers" plots illustrating the duration (in days) of bone consolidation in patients that underwent treatment of the fractures of different segments exacerbated by orthopedic infection using the external fixation apparatus. Left (a): humerus; in the middle (b): femur; right (c): tibia. Blue box and whiskers (at the left at all figures) represent data for the main study group that received surgery, antibiotic and etiologic metabolism impairment therapy; red box and whiskers (at the right at all figures) represent the control group that received surgery and antibiotic therapy, but no treatment of bone metabolism impairment.*

Metabolic disorders of bone tissue associated with orthopedic infection are complex and yet poorly understood. Research of this topic will improve not only the existing treatment strategy but also the philosophy of it and will greatly contribute

pathophysiological rationale but also by the results of our study.

to development of traumatology and orthopedics.

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**9. Conclusion**

**Figure 6.**

Archil Tsiskarashvili\*, Nikolay Zagorodny, Svetlana Rodionova and Dmitry Gorbatyuk National Medical Research Center of Traumatology and Orthopedics, Moscow, Russia

\*Address all correspondence to: archil.tsiskarashvili@gmail.com

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
