**3.1 Cytotoxicity**

Cytotoxicity assay results showed that negative and positive controls behaved as expected (i.e., percent viability ≥70% for the negative control groups and <70% for the positive control groups). The average percent viability for negative and positive controls were 94 and 4%, respectively. The average percent viability of L-MDF (91%) was above the 70% threshold, and thus, based on the criteria of the protocol and ISO 10993-5 guidelines, L-MDF are considered to be non-cytotoxic.
