**8. miRNA regulation in osteoblast proliferation**

Most often, miRNA binds to 3′UTR regions of the genes and executes its action. miRNAs are generally regarded as post-transcriptional regulators that check the process of proliferation, apoptosis, differentiation and development [64]. Several miRNAs are documented to regulate the process of osteogenic proliferation, such as excessive expression of miR-221 and miR-215 in the mouse osteoblast cells encourages the proliferative capacity of the cells [65, 66]. Likewise, downregulation of miR-185 results in the declined osteoblast proliferation [67]. Besides, increased expression of miR-495 in osteoblasts results in diminished proliferation and stimulated apoptosis in the cells [68].
