**5. Conclusion**

L-MDF were engineered with the ideal characteristics of a DBM in mind. The cortical bone fibers are demineralized to target optimal levels of residual calcium to yield tissue with osteoinductive potential, and also terminally sterilized to minimize the risk of disease transmission. The results presented here demonstrate that L-MDF exhibit the osteoinductive potential and osteoconductive properties desirable to promote bone formation while also being easy to handle for surgical procedures. These characteristics suggest that L-MDF are a suitable option to treat bone defects in a number of orthopedic, spinal, trauma, craniomaxillofacial, and dental applications.
