**5.1 Summary and conclusion**

Animal experiments using LIPUS for healing of wounds have shown effective and favorable results with histological evidence. The effects of the ultrasound waves on the cell and molecular biology phenomena of wound healing have further confirmed the fundamental mechanisms underlying this interesting wound healing treatment modality. However, we still lack clinical studies in this field, and our study is one of the few clinical trials of the effect of ultrasound therapy on osseointegration and marginal bone loss around implant-supported prosthesis, which showed favorable results. We have compared and contrasted two groups of patients receiving implant therapy where the first group was given LIPUS during the early healing period and post loading as an additional treatment modality and the second group was allowed to heal in the conventional way. Comparative bone thickness measurements using CBCT images and implant stability measurements using RFA values showed consistently higher stability with an increase in bone thickness (height and width), and the ultrasound therapy group demonstrated much higher implant stability values than the control group.

The overall clinical results contribute to the following findings:

