**4. Conclusion**

The study revealed that the stages of regeneration of bone tissue (inflammation, proliferation of osteoblasts, collagenogenesis and ossification) are accompanied by changes in the immunological status. When delayed consolidation of bone tissue revealed differences of response of individual parts of the immune system, a comparative study of the immunological parameter dynamics at normal and slow osteogenesis is possible to establish criteria for delayed consolidation of bone tissue. Prognostic criteria to the operations include increasing the concentration of IgM

and decreasing in concentration of C-reactive protein in the early postoperative period-increasing the number of leukocytes, the concentration of tumor necrosis factor, IgM, the production of superoxide anion in nitro blue tetrazolium test, as well as reducing the number of CD45<sup>+</sup> CD3<sup>+</sup> -cells, complement activity and the content of lactoferrin.

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