**4.4 Clinical significance**


**23**

*Marginal Bone Changes around Dental Implants after LIPUS Application: CBCT Study*

Animal experiments using LIPUS for healing of wounds have shown effective and favorable results with histological evidence. The effects of the ultrasound waves on the cell and molecular biology phenomena of wound healing have further confirmed the fundamental mechanisms underlying this interesting wound healing treatment modality. However, we still lack clinical studies in this field, and our study is one of the few clinical trials of the effect of ultrasound therapy on osseointegration and marginal bone loss around implant-supported prosthesis, which showed favorable results. We have compared and contrasted two groups of patients receiving implant therapy where the first group was given LIPUS during the early healing period and post loading as an additional treatment modality and the second group was allowed to heal in the conventional way. Comparative bone thickness measurements using CBCT images and implant stability measurements using RFA values showed consistently higher stability with an increase in bone thickness (height and width), and the ultrasound therapy group demonstrated much higher

*DOI: http://dx.doi.org/10.5772/intechopen.87220*

implant stability values than the control group.

The overall clinical results contribute to the following findings:

may be attributed to the design of the US delivery probe.

• LIPUS enhances bone formation around dental implants as confirmed by radiological investigations, RFA values, and pre and post prosthetic loading

• LIPUS technique employed in this study promoted increased in buccal bone plate height and width much more than that occurred in the palatal side. This

• With an increase in bone height and width, we expect a simultaneous increase in bone-implant contact that leads to higher osseointegration as evidenced by

This work was supported by Research University Individual (RUI) grant,

account no. 1001/PPSG/812207 from Universiti Sains Malaysia (USM).

**5.1 Summary and conclusion**

**5. Conclusion**

behaviors.

RFA values.

**Acknowledgements**

**Abbreviations**

μCT micro-CT 2-D two dimensional 3-D three dimensional AB apico-buccal AD apico-distal

ALP alkaline phosphatase

BMP bone morphogenetic proteins

AM apico-mesial AP apico-palatal

CB corono-buccal

*Marginal Bone Changes around Dental Implants after LIPUS Application: CBCT Study DOI: http://dx.doi.org/10.5772/intechopen.87220*
