**3. Results and discussion**

As a model for studying the dynamics of immunological parameters in normal and complicated osteogenesis, the study used laboratory parameters in patients with lesions of the facial skeleton. Injury of facial skeleton, especially with slow consolidation of bone tissue, leads to disturbances of body functions and generating esthetic defects. Therefore, the creation of forecasting system complications of osteogenesis in the recovery of fractures of the lower jaw becomes important. To address the issue of participation of immunological reactions in the restoration of bone tissue, first consider the dynamics of the main laboratory parameters during normal consolidation lesions of the mandible. Before operation values, immunological parameters were compared to known literature data [58, 59].

#### **3.1 Features of immune responses of peripheral blood in normal bone consolidation**

Before surgery, along with a slight increase in the relative number of CD45<sup>+</sup> CD3<sup>+</sup> -, CD45<sup>+</sup> CD19<sup>+</sup> -cells revealed increased production of IgA and IgM (**Table 1**). There was also a decrease in the activity of oxygen-dependent (nitro blue


**Laboratory**

**163**

IL-8, pg/ml IL-10, pg/ml Ceruloplasmin,

C-reactive protein, mg/l

*\**

*p < 0.05 compared with preoperative*

**Table 1.** *Immunological*

 *parameters*

 *of peripheral*

 *blood in the regeneration*

 *of bone tissue.*

 *levels.*

 g/l

 **parameters**

**Normal values Before surgery**

0–50

<1.0

0.24–0.42

0–8

 11.50

5.50

 7.50

2.95

 30.84

13.40

 1.40

0.25\*

0.61

0.02\*

*Immunological Monitoring of Osteogenesis Disorder DOI: http://dx.doi.org/10.5772/intechopen.92099*

> 0.53

0.02

 0.40

0.05\*

0.55

0.10

 0.29

0.04\*

0.33

0.07\*

 2.31

0.08

 0.07

0.02\*

0.02

0.01\*

0.09

0.03\*

0.92

0.04\*

 42.88

3.64

 76.03

3.60\*

415.12

11.98\*

70.47

2.65\*

39.74

2.99

 **3 days**

 **10 days**

 **1 month**

 **3 months**


#### **Table 1.**

*Immunological parameters of peripheral blood in the regeneration of bone tissue.*
