**11.1 miRNA-based therapeutics in osteoporosis**

During osteoporosis, the balance between bone formation and bone elimination is disrupted [89]. Bone dissolution dominates the bone formation and thereby results in the weakened matrix and compromised bone strength. miRNA attempts to correct the imbalance and preserves the bone homeostasis towards bone development during the process of remodeling. miRNAs suppress the genes or proteins involved in the biological signaling pathway and hence aid the pathway to proceed in accurate and normal fashion [90]. This normalization of the pathway further facilitates the optimum differentiation of the mesenchymal stem cells to the osteoblastic lineage. In the past few years, several investigations have emerged which conveys the role of miRNAs in the prognosis and treatment of osteoporosis (**Table 4**).


**Table 4.**

*Representation of the current studies where miRNAs are used as therapeutics in the treatment of osteoporosis.*
