**Acknowledgements**

*Quinazolinone and Quinazoline Derivatives*

At the end of the experiment, we wanted to see if the new quinazolinones had any influence on the anxious natural behavior of the mice. It is well known that placed in the plus maze, mice prefer to explore closed and secure arms instead of open ones, associated with imminent danger. The results in elevated plus maze test evidenced a slight anxiolytic effect for two new compounds, Q3 and Q5. They increased the time spent in the open arms of the maze with 20.74 and 15.61% compared with control group. The mean results can be observed in **Figure 4**.

*Time in closed arms of EPM after 15 days of administration (the columns represent the mean + SD).*

Also, the same two compounds produced a decrease of the time spent in closed

We obtained five new 4(3H)-quinazolinone derivatives through a standardized synthesis process. The compounds were characterized by measuring the melting points, by determining the infrared and NMR spectra, and by elemental

The pharmacological tests evidenced that the five new quinazolinones have a

Regarding the results obtained in pharmacological tests for evaluation of antidepressant and anxiolytic effects, the compounds had different actions, probably

Thus, Q1 which have the nitro group in structure manifested the highest antidepressant effect, with a reduction of immobilization time in FST with 20.39% and in

On the other hand, compounds Q3 and Q5, with two groups methoxy, respective ethoxy, had a slight anxiolytic effect, highlighted by increasing the time spent in

The five new compounds have been shown to have central nervous system activity, and we consider that they deserve further testing in order to detect other effects

very low acute toxicity, lethal doses being >2000 mg/kg bw.

influenced by the presence of different radicals on the nucleus.

open arms, with 20.74 and 15.61% compared with control.

TST with 20.13% compared with control.

arms of the maze, with 5.92 and 4.92% compared with control (**Figure 5**). The preference of the animals for the open arms instead of closed ones is a sign of lower anxiety, thus we can affirm that compounds Q3 and Q5 have a slight anxiolytic effect. The other compounds did not influence the parameters in EPM.

**102**

of interest.

**4. Conclusion**

analysis.

**Figure 5.**

We would like to thank Mr. Miron Teodor Căproiu from The Organic Chemistry Center of Romanian Academy "C.D. Neniţescu," for performing the physicochemical determinations.
