**3. Conclusion**

The author has reported the synthesis of novel series of quinazolines based Schiff bases from hydroxynaphthanones and 3-amino-2-methyl-3H-quinazolin-4-one using classical procedure under slightly acidic conditions.

## **4. Result and discussion**

Quinazoline derivatives are further classified into the following main five categories. This classification is on the basis of their substitution patterns present in the ring system [3]. These are 2-substituted-4(3*H*)-quinazolinones, 3-substituted-4(3*H*)-quinazolinones, 4-substituted-quinazolines, 2,3-disubstituted-4(3*H*) quinazolinones, and 2,4-disubstituted-4(3*H*)-quinazolinones. In view of the importance of quinazoline derivatives, the present study describes the synthesis of some important quinazoline based imines. The mixture of corresponding 3-amino-2-methyl-3*H*-quinazolin-4-one and substituted naphthnones treated in presence slightly acidic condition under reflux for 3 h to give formation imines (**Figure 2**). The formation of imines confirmed on the basis of spectral data, the IR spectra reveals the stretching band around 1630 cm<sup>−</sup><sup>1</sup> is due to imines C=N. The NMR reveals the absence of –NH2 protons around δ 5.2 confirms the condensation reaction carried successfully. The mass spectrum of compounds **2a–d** gives molecular ion which is corresponding to molecular weight of products.

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**Author details**

Maharashtra, India

Sainath Bhanudas Zangade

Department of Chemistry, Madhavrao Patil ACS College, Parbhani,

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

\*Address all correspondence to: drsbz@rediffmail.com

provided the original work is properly cited.

*Quinazoline Based Synthesis of some Heterocyclic Schiff Bases*

The authors confirm that this article content has no conflict of interest.

*DOI: http://dx.doi.org/10.5772/intechopen.89871*

**Conflict of interest**
