**5. Conclusions**

This chapter depicts different methods of synthesis of quinazolinone derivatives starting from affordable and easily accessible substrates including 2-aminobenzoic acid, 2-aminobenzamide, o-substituted aniline in addition to the synthetic methods of spiroquinazolinones and heterocycle-fused quinazolinones. Also, the chapter discusses different biological applications of both natural and synthetic quinazolinones. The last section in this chapter lists common quinazolinone drugs that have been approved in the market.

#### **Acknowledgements**

This book chapter was supported by King Saud University, Vice Deanship of Research Chairs, Kayyali Chair for Pharmaceutical Industry, through grant number AW-2019.

**29**

**Author details**

University, Egypt

Riydh, Saudi Arabia

Awwad A. Radwan1,2\* and Fars K. Alanazi1,3

provided the original work is properly cited.

1 Kayyali Chair, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

2 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut

3 Department of Pharmaceutics, College of Pharmacy, King Saud University,

\*Address all correspondence to: aradwan@ksu.edu.sa; dhna\_2001@hotmail.com

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

*Biological Activity of Quinazolinones*

*DOI: http://dx.doi.org/10.5772/intechopen.90621*

## **Conflict of interest**

The authors declare no conflict of interest.

*Biological Activity of Quinazolinones DOI: http://dx.doi.org/10.5772/intechopen.90621*

*Quinazolinone and Quinazoline Derivatives*

*Chemical structure of marketed quinazolinone drugs.*

muscle relaxant drug.

**Figure 18.**

**5. Conclusions**

the counter supplements.

been approved in the market.

**Acknowledgements**

**Conflict of interest**

The authors declare no conflict of interest.

AW-2019.

The brand name of afloqualone is Arofuto® (**138**; **Figure 18**) [113]. It is marketed by Mitsubishi Tanabe Pharma pharmaceutical company as sedative and

Evodiamine (**139**; **Figure 18**) [114] has been isolated from the Evodia plants and was found to reduce fat uptake in animal model. It is used for bodybuilding as over

This chapter depicts different methods of synthesis of quinazolinone derivatives starting from affordable and easily accessible substrates including 2-aminobenzoic acid, 2-aminobenzamide, o-substituted aniline in addition to the synthetic methods of spiroquinazolinones and heterocycle-fused quinazolinones. Also, the chapter discusses different biological applications of both natural and synthetic quinazolinones. The last section in this chapter lists common quinazolinone drugs that have

This book chapter was supported by King Saud University, Vice Deanship of Research Chairs, Kayyali Chair for Pharmaceutical Industry, through grant number

**28**
