**Conflict of interest**

*Quinazolinone and Quinazoline Derivatives*

1775, 1628, 1547, 1465, 815, 668. <sup>1</sup>

EI) *m/z* (%): 453 (M+, 57%).

2-methylquinazolin-4(3H)-one.

1772, 1630, 1549, 1460, 818, 663. <sup>1</sup>

(MS, EI) *m/z* (%): 406 (M+, 69%).

2-methylquinazolin-4(3H)-one.

1774, 1632, 1544, 1462, 816, 665. <sup>1</sup>

EI) *m/z* (%): 361.5 (M+, 65%).

2-methylquinazolin-4(3H)-one.

1773, 1635, 1546, 1465, 818, 667. <sup>1</sup>

(MS, EI) *m/z* (%): 327(M+, 64%).

reveals the stretching band around 1630 cm<sup>−</sup><sup>1</sup>

ion which is corresponding to molecular weight of products.

**3. Conclusion**

**4. Result and discussion**

Appearance: light yellow solid, FT-IR (KBr, ν, cm<sup>−</sup><sup>1</sup>

Appearance: light yellow solid, FT-IR (KBr, ν, cm<sup>−</sup><sup>1</sup>

Appearance: light yellow solid, FT-IR (KBr, ν, cm<sup>−</sup><sup>1</sup>

• (E)-3-((1-(1-hydroxynaphthalen-2-yl)ethylidene)amino)-

Appearance: light yellow solid, FT-IR (KBr, ν, cm<sup>−</sup><sup>1</sup>

4-one using classical procedure under slightly acidic conditions.

• (E)-3-((1-(4-bromo-1-hydroxynaphthalen-2-yl)ethylidene)amino)-

• (E)-3-((1-(4-chloro-1-hydroxynaphthalen-2-yl)ethylidene)amino)-

(s, 2H, OH), 6.69–8.29 (m, 9H, ArH), 3.26 (s, 3H, CH3)2.61 (s, 3H, CH3). (MS,

12.5 (s, 2H, OH), 6.67–8.29 (m, 9H, ArH), 3.26 (s, 3H, CH3)2.61 (s, 3H, CH3).

(s, 2H, OH), 6.68–8.29 (m, 9H, ArH), 3.27 (s, 3H, CH3)2.61 (s, 3H, CH3). (MS,

(s, 2H, OH), 6.68–8.29 (m, 10H, ArH), 3.25 (s, 3H, CH3)2.62 (s, 3H, CH3).

The author has reported the synthesis of novel series of quinazolines based Schiff bases from hydroxynaphthanones and 3-amino-2-methyl-3H-quinazolin-

Quinazoline derivatives are further classified into the following main five categories. This classification is on the basis of their substitution patterns present in the ring system [3]. These are 2-substituted-4(3*H*)-quinazolinones, 3-substituted-4(3*H*)-quinazolinones, 4-substituted-quinazolines, 2,3-disubstituted-4(3*H*) quinazolinones, and 2,4-disubstituted-4(3*H*)-quinazolinones. In view of the importance of quinazoline derivatives, the present study describes the synthesis of some important quinazoline based imines. The mixture of corresponding 3-amino-2-methyl-3*H*-quinazolin-4-one and substituted naphthnones treated in presence slightly acidic condition under reflux for 3 h to give formation imines (**Figure 2**). The formation of imines confirmed on the basis of spectral data, the IR spectra

reveals the absence of –NH2 protons around δ 5.2 confirms the condensation reaction carried successfully. The mass spectrum of compounds **2a–d** gives molecular

): 3237, 3065, 2925,

): 3242, 3068, 2933,

): 3247, 3063, 2935,

): 3242, 3067, 2937,

H NMR (300 MHz, DMSO-*d*6, δ, ppm): 12.5

H NMR (300 MHz, DMSO-*d*6, δ, ppm):

H NMR (300 MHz, DMSO-*d*6, δ, ppm): 12.5

H NMR (300 MHz, DMSO-*d*6, δ, ppm): 12.5

is due to imines C=N. The NMR

**110**

The authors confirm that this article content has no conflict of interest.
