**Author details**

*Quinazolinone and Quinazoline Derivatives*

tion, pathogenic viruses, and fungi [30].

toxic:

methyluracil [32].

with chloroquin [35].

inflammatory mechanisms.

anti-inflammatory and analgesic activity [36].

revealed that Compound D is an anti-hypoxic agent [37].

biological activities of quinazolinone and quinazoline derivatives.

Liv-52 [33].

2-Styril-4-aminoquinazolinones are characterized by strong activity in respect of gram-positive bacteria, *Mycobacterium tuberculosis*, pathogenic proterozoic infec-

Pharmacological screening of some derivatives of quinazolinone-4 has allowed revealing for analeptic, anti-inflammatory, and anti-hypoxic activity and slightly

4-Amino-4′-[2-phenyl-4-oxoquinazoline-3]-diphenylsulfone (QPhD) and 4,4'-bis-[2-phenyl-4-oxoquinazoline-3]-diphenylsulfone (BisQPhD) have analeptic, anti-inflammatory, and anti-hypoxic activities and are slightly toxic [21, 31]. In one study 4-amino-4′-[2-phenyl-4-oxoquinazoline-3]-diphenylsulfone (QPhD) shows strong immunotropic activity surpassing the comparing drug

In one study 4-(4-Oxo-2-phenyl-4H-quinazolin-3-yl)-N-pyrimidin-2-ylbenzenesulfonamide (Compound A) and N-(4,6-Dimethyl-pyrimidin-2-yl)-4- (4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzenesulfonamide (Compound B) show strong hepatoprotective and antioxidant activity surpassing the comparing drug

Accessibility of quinazoline derivatives and versatility of their biological activity attract well-earned attention to similar class of substances. The similarity is not only physicochemical properties of pyrimidine and quinazolinone, but also spectrum of biological activity opens the new possibilities for searching for high active compounds in these class substances [10, 34]. The extensive array of information, denoted synthesis, and study of the biological activity of derivatives of quinazolinon-4 is indicative of exclusive possibility of the synthesis of new biologically active compounds. Synthesis of 4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-N-pyrimidin-2-yl-benzenesulfonamide (Compound A) and N-(4,6-dimethyl-pyrimidin-2-yl)-4-(4-oxo-2-phenyl-4H-quinazolin-3-yl) benzenesulfonamide (Compound B) showed high antimalarial activity compared

The synthesis of 4-(4-oxo-2-phenyl-4H-quinazolin-3-yl) benzene sulfonamide (Compound A) and N-acetyl-4-(4-oxo-2-phenyl-4H-quinazolin-3-yl) benzenesulfonamide (Compound C) having analgesic and anti-inflammatory activities but Compound C showed a significant activity than Compound A; also the Compound A has a pharmacological activity more significant than standard drug diclofenac. Further studies are important to ensure their analgesic and anti-

The docking study explains the inhibitory effect of the A and C compounds against the in vivo anti-inflammatory and analgesic activity. The compounds A and C have similar effect as diclofenac and indomethacin reference drugs in the in vivo

sulfonamide (Compound B) and N-(4,6-dimethyl-pyrimidin-2-yl)-4-(4-oxo-2 phenyl-4H-quinazolin-3-yl)-benzene sulfonamide (Compound D) gave a Pa < 0.5 as nootropic by the PASS program, but experiments on animals confirmed the antihypoxic activity of the compounds, which means they might occur as new chemical entities. Compound D has shown the strongest anti-hypoxic activity. A docking study of the synthesized derivatives with GluA3 confirmed the result in vitro and

Our aim is to focus on all the methods for synthesis and different interesting

Our major objective of this project is to give the information in a lucid, condensed, and cohesive form and to specially cater the needs of readers in medicine

Synthesis of 4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-N-pyrimidin-2-yl-benzene

**6**

and pharmacy.

Ali Gamal Al-kaf Medicinal Chemistry Department, Faculty of Pharmacy, Sana'a University, Sana'a, Yemen

\*Address all correspondence to: alialkaf21@gmail.com

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
