Scope of the Series

Contents

**Section 1**

**Section 2**

*by Akhlash P. Singh*

*by Prasat Kittakoop*

**Section 3**

Bowel Disease?

**Preface XI**

Microbiome Research Technologies **1**

**Chapter 1 3**

Microbiota in Health and Diseases **25**

**Chapter 2 27**

**Chapter 3 43**

**Chapter 4 67**

**Chapter 5 87**

Search for Therapeutic Approaches **127**

**Chapter 6 129**

**Chapter 7 139**

Contribution of Gut Microbiome to Human Health and the Metabolism

Is a Fecal Microbiota Transplant Useful for Treating Inflammatory

*by Andra-Iulia Suceveanu, Andrada Dumitru, Marilena Musat, Claudia Voinea, Felix Voinea, Irinel Parepa, Anca Pantea Stoian,* 

*by Najaf Allahyari Fard, Zakie Mazhary and Nahid Javanshir*

Genomic Techniques Used to Investigate the Human Gut Microbiota

"Dialogue" between the Human Microbiome and the Brain

Intestinal Dysbiosis and Non-Alcoholic Fatty Liver Disease

Skin and Gut Microbiota in Psoriasis: A Systematic Review *by Atiya Rungjang, Jitlada Meephansan and Hok Bing Thio*

*by Natalia Beloborodova and Andrey Grechko*

*by Teresa Auguet, Laia Bertran and Jessica Binetti*

or Toxicity of Drugs and Natural Products

*Laura Mazilu and Adrian Paul Suceveanu*

Probiotic Bacteria in Microbiome against Allergy

Biochemistry, the study of chemical transformations occurring within living organisms, impacts all of the life sciences, from molecular crystallography and genetics, to ecology, medicine and population biology. Biochemistry studies macromolecules - proteins, nucleic acids, carbohydrates and lipids –their building blocks, structures, functions and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins and hormones, which play roles in the life process. Biochemical experimentation, besides coopting the methods of classical chemistry, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the 'big data' omics systems.

Initial biochemical studies have been exclusively analytic: dissecting, purifying and examining individual components of a biological system; in exemplary words of Efraim Racker, (1913 –1991) "Don't waste clean thinking on dirty enzymes." Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe fully a particular biological system. The 'big data' metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the proteins comprising e.g., serum; metagenomics can identify all the genes in a complex environment e.g., the bovine rumen. This Biochemistry Series will address both the current research on biomolecules, and the emerging trends with great promise.
