**Abstract**

**References**

*Oral Diseases*

jcpe.12935

[1] Newman MG, Takei HH,

13th ed. Philadelphia: Elsevier Saunders; 2019. pp. 55-79

[2] Newman MG, Takei HH,

13th ed. Philadelphia: Elsevier Saunders; 2019. pp. 248-302

Klokkevold PR, Carranza FA. Newman and Carranza's Clinical Periodontology. 10th ed. Ontario: BC Decker Inc; 2003.

[10] Greenberg MS, Glick M. Burket's Oral Medicine Diagnosis & Treatment. 10th ed. Ontario: BC Decker Inc; 2003.

[11] Pundir A, Farista S, Afroz SA. Calcifying fibroblastic granuloma—A rare case report. International Journal of Scientific and Research Publications.

pp. 441-490

pp. 552-555

2013;**3**:1-3

Klokkevold PR, Carranza FA. Newman and Carranza's Clinical Periodontology.

[3] Caton J, Armitage G, Berglundh T, et al. A new classification scheme for periodontal and periimplant diseases and conditions—Introduction and key changes from the 1999 classification. Journal of Clinical Periodontology. 2018; **45**(Suppl 20):S1-S8. DOI: 10.1111/

[4] Chapple ILC. Dental plaque–induced gingival conditions. Journal of Clinical Periodontology. 2018;**45**(Suppl 20): S17-S27. DOI: 10.1111/jcpe.12937

Klokkevold PR, Carranza FA. Newman and Carranza's Clinical Periodontology.

[6] Mani A, Anarthe R, Marawar PP, Mustilwar RG, Bhosale A. Diagnostic kits: An aid to periodontal diagnosis. Journal of Dental Research and Review.

[7] Holmstrup P, Plemons J, Meyle J. Non–plaque-induced gingival diseases. Journal of Clinical Periodontology. 2018; **45**(Suppl 20):S28-S43. DOI: 10.1111/

[8] Greenberg MS, Glick M. Burket's Oral Medicine Diagnosis & Treatment. 10th ed. Ontario: BC Decker Inc; 2003.

[9] Greenberg MS, Glick M. Burket's Oral Medicine Diagnosis & Treatment.

[5] Newman MG, Takei HH,

13th ed. Philadelphia: Elsevier Saunders; 2019. pp. 378-396

2016;**3**:107-113

jcpe.12938

pp. 50-118

**48**

Host modulation is considered to be new research area in dentistry. In medicine, host modulation was introduced way before dentistry in treating arthritis and osteoporosis. It is mainly focusing on the host part during host-bacteria interaction. Although there are many agents introduced for this purpose, the most well-studied host modulation therapy in dentistry is doxycycline. It shows less tissue destruction when used for few months along with periodontal therapy. It has anticollagenase properties which shows a promising effect when used to treat chronic inflammation.

**Keywords:** host modulation, doxycycline, anticollagenase, matrix metalloproteinases enzymes
