**3.1 Enamel matrix proteins, growth factors, and bone morphogenetic proteins**

The locally administered host modulation therapy is used mainly to improve wound healing, increase bone formation, and to produce new periodontal tissue including periodontal ligament and cementum. They have been applied locally along with periodontal surgery. The FDA approved local host modulatory agents includes enamel matrix proteins (Emdogain), recombinant human platelet-derived growth factor-BB (GEM 21S), and BMP-2 (rhBMP-2 [Infuse]). These materials have been proved to provide some clinical benefits when used during periodontal surgical procedures. The focus of this chapter is on the non-surgical therapy of gingivitis and periodontitis.
