**4. Risk factors for osteolysis**

Although the final pathway to the development of aseptic loosening is process of mechanical failure of the construct driven by inflammatory-mediated bone loss, multiple factors mediate an individual's susceptibility to this process. These may broadly be divided into patient, surgical, and prosthesis-related factors (Figure 4). Although not an exhaustive list, some of these proposed factors that have been identified and validated will be discussed.

Fig. 4. Summary of risk factors that influence the development of aseptic loosening
