**6.3 Glutathione determination**

Level of reduced and oxidized glutathione was elevated in both groups compared to controls. However, a lower statistically significant GSH/GSSG ratio was detected only in Group II compared to Group I and controls (p=0.005 and p=0.024, respectively). GSH and GSSG concentrations and GSH/GSSG ratio in the two groups and controls are given in Table 1.


\* p<0.0001, \*\* p<0.024 versus the control group; \*\*\* p<0.045, \*\*\*\* p<0.005 versus Group I

Table 1. The levels of GSH, GSSG, as well as GSH/GSSG ratio in periprosthetic tissues and controls. Values measured in µmol/mg hydroxyproline. Data represented as mean SD.
