**Table 1.**

**107**

*lncRNAs in Hallmarks of Cancer and Clinical Applications*

be promising as biomarkers and potential therapeutic targets.

Leandro Garcia, Erika Zambalde, Carolina Mathias, Jéssica Barazetti,

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

\*Address all correspondence to: jaqueline.genetica@gmail.com

The authors declare no conflict of interest.

The vast number of studies describing lncRNAs associated with several tumor types and regulating several processes of cancer cells is shown here. The great advance in RNA sequencing technology allows us to identify new molecules and characterized better lncRNAs. From the discovery of these molecules, in the beginning, they appeared to have no important functions; however, today many researches in this area propose that more information about these molecules may help us understand numerous characters of tumor cells that are still unknown. Some lncRNAs are associated with several hallmarks of cancer demonstrating the importance of these molecules in the mechanism of disease, like MALAT and HOTAIR. Other are already utilized as biomarker in prostate cancer like PCA3. Considering the challenges for *in vivo* experimental designs, lncRNAs continue to

*DOI: http://dx.doi.org/10.5772/intechopen.88903*

**4. Conclusion**

**Conflict of interest**

**Author details**

Daniela Gradia and Jaqueline Oliveira\* Federal University of Parana, Curitiba, Brazil

provided the original work is properly cited.

*lncRNAs with potential to be used as biomarkers, in several types of cancer.*
