**1. Introduction**

Chronic disease as defined by the U.S. National Center for Health Statistics is a disease that is pervasive and persists 3 months or more. About 60% of adults in the United States possess a chronic disease meanwhile about 40% possess two or more

diagnoses indicative of chronic disease [1]. By 2030, it is predicted that the U.S. population, predominantly individuals age 65 years and older, could possess three or more chronic diseases [2]. Non-communicable chronic diseases such as: coronary artery disease, ischemic heart disease, asthma, COPD, chronic bronchitis, emphysema, Alzheimer's disease, stroke, hepatic disease, type 1 diabetes, type 2 diabetes, depression, PTSD and an assortment of cancers, possess significant implications pertaining to international health. Chronic disease is a predominant cause of premature death and disability.

In 2016, direct domestic costs related to the medical management of chronic disease approximated 6% of the GDP, including roughly \$3.3 trillion in indirect costs like work loss, worker replacement and diminished economic productivity [3]. Direct costs average approximately \$3300 per person and indirect costs average approximately \$7901 per person [2]. Examples of the financial implications of chronic disease include \$189.6 billion in care expenditures that comprise the management of diabetes and the \$185.9 billion that comprise the management of Alzheimer's disease [3]. These totalities pose significant problems to the patient, the relatives of the patient, employers and the economy. The increase in the prevalence of chronic disease certainly will increase direct costs, indirect costs and expenditures in the U.S. healthcare system.

Several studies have attempted to ascertain the predisposition for chronic disease in particular individuals. The innovative and inventive 1998 CDC-Kaiser Permanente Adverse Childhood Experiences (ACE) study validates the interconnection of chronic disease states and health-harming behaviors subsequent to the exposure of adverse childhood experiences. This retrospective study surveyed 13,494 patients with 9508 respondents by use of their health history and a health appraisal questionnaire. The ACE study and successive similar studies acknowledge the importance of potential prevention of adverse childhood experiences because of their contribution to chronic disease through maladaptive adulthood behaviors that perpetuate pathologic conditions. Through early identification of these interconnections that predispose individuals to costly chronic disease, practitioners and medical organizations anticipate having the ability to address and advocate for the appropriate deterrence of adverse childhood experiences that contributes to the development of chronic disease in adulthood.

#### **2. Methodology**

Previous studies, such as the prominent Adverse Childhood Experiences (ACE) study by CDC-Kaiser Permanente that considers the correlation among chronic disease in adulthood and adverse childhood experiences, employed substantiated surveys. These substantiated surveys included an assortment of adverse exposures, categorized as abuse, neglect or adversity in the household. Said surveys were devised using pre-existing published surveys like the Behavioral Risk Factor Surveillance System (BRFSS) survey. Accordingly, several analogous studies, including prospective study of one's childhood and retrospective study that recalls one's childhood, arose that included use of similar substantiated surveys. Additionally, multivariable logistic regression models were used to adjust odds ratios (OR) and confidence intervals (CI) that assess for associations among ACEs and adulthood chronic disease.

A website search engine was used to assist in the selection of an assortment of studies. Scholarly sources such as the National Library of Medicine, particularly the National Center for Biotechnology Information including peer-reviewed literature catalogs like PubMed was used. Inclusion criteria included: sample sizes of at least

**171**

*The Relationship of Adulthood Chronic Disease and Adverse Childhood Experiences (ACEs)…*

100 patients, a population of patients at least 18 years of age, the ability to assess for multiple ACEs, the ability to assess prevalence of ACEs among a diverse patient population pertaining to age, gender, race, ethnicity and education and statistical analysis of the correlation among the instances of ACEs and likelihood of chronic

Adverse Childhood Experiences (ACEs) are defined as direct or indirect childhood abuse and domestic disruption before the age of 18, denoted by seven categories in the health appraisal questionnaire including: psychological abuse, physical abuse, sexual abuse, substance abuse, domestic violence, psychiatric illness including suicidal ideation or attempt and incarceration. Studies illustrate that individuals that have encountered ACEs are likelier to engage in maladaptive, high-risk, healthharming behaviors that typically commence at the age of adolescence. The maladaptive adulthood behaviors that contribute to chronic disease include: excessive alcohol use, tobacco use, physical inactivity, psychiatric illness including suicidal ideation or attempts, promiscuous sexual behavior (>50 sex partners), history of

Throughout the years, several studies, including the influential ACE study, have recognized the relationship among early exposure to ACEs and the prevalence of chronic disease. ACE exposure predisposes individuals to poorer physical and mental health in comparison to individuals that do not encounter ACEs because of a higher likelihood that said individuals partake in high-risk behavior that is detrimental to their health [4]. Fifty six percent of individuals that lack exposure to ACE possessed none of the high-risk behaviors that are linked to chronic disease, meanwhile merely 14% of individuals that encountered 4 or more ACEs possessed none of the high-risk behaviors [5]. An average of 54.5% of individuals who encountered one instance of ACE encountered multiple instances of ACEs throughout their childhood. Repeated exposures to ACEs exacerbate the high-risk, health-harming behaviors that increase the likelihood of an individual developing chronic disease in adulthood. Individuals that encountered 6 or more ACEs are 1.7 times more likely to die before the age of 75 [6]. This affirms a dose-dependent relationship among the number of ACEs encountered and the likelihood that an individual possesses the high-risk behavior that results in a higher morbidity and mortality in regard to their chronic disease (**Figure 1**). Unfortunately, ACEs are common in the early years of development with the most prevalent being exposure to substance abuse (25.6%) while the least prevalent is exposure to criminal behavior including incarceration (3.4%). Several studies use an odds ratio (OR) in an attempt to assess the association among ACE exposure and consequent maladaptive behaviors that precipitate the development of chronic disease. To illustrate the association among exposure and outcome, recall that an OR greater than 1 means that there are greater odds of an association among exposure and outcome. A modest association for physical inactivity, severe obesity and diabetes (OR less than 2) is present in individuals encountering at least 4 ACEs. A moderate association (OR 2–3) is present for smoking, excessive alcohol use, tobacco use, cardiovascular disease, respiratory disease and cancer in addition to substandard self-reported health. Likewise, excessive alcohol and tobacco users are approximately six-times likelier to have encountered an ACE. A strong association

), resulting from unhealthy diet.

*DOI: http://dx.doi.org/10.5772/intechopen.93520*

**3. What is an adverse childhood experience?**

STI/STD and severe obesity (BMI > 35 kg/m2

**4. Relationship among ACEs and chronic disease**

disease in adulthood.

*The Relationship of Adulthood Chronic Disease and Adverse Childhood Experiences (ACEs)… DOI: http://dx.doi.org/10.5772/intechopen.93520*

100 patients, a population of patients at least 18 years of age, the ability to assess for multiple ACEs, the ability to assess prevalence of ACEs among a diverse patient population pertaining to age, gender, race, ethnicity and education and statistical analysis of the correlation among the instances of ACEs and likelihood of chronic disease in adulthood.

### **3. What is an adverse childhood experience?**

*Contemporary Developments and Perspectives in International Health Security - Volume 1*

premature death and disability.

tures in the U.S. healthcare system.

development of chronic disease in adulthood.

**2. Methodology**

and adulthood chronic disease.

diagnoses indicative of chronic disease [1]. By 2030, it is predicted that the U.S. population, predominantly individuals age 65 years and older, could possess three or more chronic diseases [2]. Non-communicable chronic diseases such as: coronary artery disease, ischemic heart disease, asthma, COPD, chronic bronchitis, emphysema, Alzheimer's disease, stroke, hepatic disease, type 1 diabetes, type 2 diabetes, depression, PTSD and an assortment of cancers, possess significant implications pertaining to international health. Chronic disease is a predominant cause of

In 2016, direct domestic costs related to the medical management of chronic disease approximated 6% of the GDP, including roughly \$3.3 trillion in indirect costs like work loss, worker replacement and diminished economic productivity [3]. Direct costs average approximately \$3300 per person and indirect costs average approximately \$7901 per person [2]. Examples of the financial implications of chronic disease include \$189.6 billion in care expenditures that comprise the management of diabetes and the \$185.9 billion that comprise the management of Alzheimer's disease [3]. These totalities pose significant problems to the patient, the relatives of the patient, employers and the economy. The increase in the prevalence of chronic disease certainly will increase direct costs, indirect costs and expendi-

Several studies have attempted to ascertain the predisposition for chronic disease in particular individuals. The innovative and inventive 1998 CDC-Kaiser Permanente Adverse Childhood Experiences (ACE) study validates the interconnection of chronic disease states and health-harming behaviors subsequent to the exposure of adverse childhood experiences. This retrospective study surveyed 13,494 patients with 9508 respondents by use of their health history and a health appraisal questionnaire. The ACE study and successive similar studies acknowledge the importance of potential prevention of adverse childhood experiences because of their contribution to chronic disease through maladaptive adulthood behaviors that perpetuate pathologic conditions. Through early identification of these interconnections that predispose individuals to costly chronic disease, practitioners and medical organizations anticipate having the ability to address and advocate for the appropriate deterrence of adverse childhood experiences that contributes to the

Previous studies, such as the prominent Adverse Childhood Experiences (ACE) study by CDC-Kaiser Permanente that considers the correlation among chronic disease in adulthood and adverse childhood experiences, employed substantiated surveys. These substantiated surveys included an assortment of adverse exposures, categorized as abuse, neglect or adversity in the household. Said surveys were devised using pre-existing published surveys like the Behavioral Risk Factor Surveillance System (BRFSS) survey. Accordingly, several analogous studies, including prospective study of one's childhood and retrospective study that recalls one's childhood, arose that included use of similar substantiated surveys. Additionally, multivariable logistic regression models were used to adjust odds ratios (OR) and confidence intervals (CI) that assess for associations among ACEs

A website search engine was used to assist in the selection of an assortment of studies. Scholarly sources such as the National Library of Medicine, particularly the National Center for Biotechnology Information including peer-reviewed literature catalogs like PubMed was used. Inclusion criteria included: sample sizes of at least

**170**

Adverse Childhood Experiences (ACEs) are defined as direct or indirect childhood abuse and domestic disruption before the age of 18, denoted by seven categories in the health appraisal questionnaire including: psychological abuse, physical abuse, sexual abuse, substance abuse, domestic violence, psychiatric illness including suicidal ideation or attempt and incarceration. Studies illustrate that individuals that have encountered ACEs are likelier to engage in maladaptive, high-risk, healthharming behaviors that typically commence at the age of adolescence. The maladaptive adulthood behaviors that contribute to chronic disease include: excessive alcohol use, tobacco use, physical inactivity, psychiatric illness including suicidal ideation or attempts, promiscuous sexual behavior (>50 sex partners), history of STI/STD and severe obesity (BMI > 35 kg/m2 ), resulting from unhealthy diet.

#### **4. Relationship among ACEs and chronic disease**

Throughout the years, several studies, including the influential ACE study, have recognized the relationship among early exposure to ACEs and the prevalence of chronic disease. ACE exposure predisposes individuals to poorer physical and mental health in comparison to individuals that do not encounter ACEs because of a higher likelihood that said individuals partake in high-risk behavior that is detrimental to their health [4]. Fifty six percent of individuals that lack exposure to ACE possessed none of the high-risk behaviors that are linked to chronic disease, meanwhile merely 14% of individuals that encountered 4 or more ACEs possessed none of the high-risk behaviors [5]. An average of 54.5% of individuals who encountered one instance of ACE encountered multiple instances of ACEs throughout their childhood. Repeated exposures to ACEs exacerbate the high-risk, health-harming behaviors that increase the likelihood of an individual developing chronic disease in adulthood. Individuals that encountered 6 or more ACEs are 1.7 times more likely to die before the age of 75 [6]. This affirms a dose-dependent relationship among the number of ACEs encountered and the likelihood that an individual possesses the high-risk behavior that results in a higher morbidity and mortality in regard to their chronic disease (**Figure 1**).

Unfortunately, ACEs are common in the early years of development with the most prevalent being exposure to substance abuse (25.6%) while the least prevalent is exposure to criminal behavior including incarceration (3.4%). Several studies use an odds ratio (OR) in an attempt to assess the association among ACE exposure and consequent maladaptive behaviors that precipitate the development of chronic disease. To illustrate the association among exposure and outcome, recall that an OR greater than 1 means that there are greater odds of an association among exposure and outcome. A modest association for physical inactivity, severe obesity and diabetes (OR less than 2) is present in individuals encountering at least 4 ACEs. A moderate association (OR 2–3) is present for smoking, excessive alcohol use, tobacco use, cardiovascular disease, respiratory disease and cancer in addition to substandard self-reported health. Likewise, excessive alcohol and tobacco users are approximately six-times likelier to have encountered an ACE. A strong association

**Figure 1.**

*ACEs effects on health and well-being as adapted from Felitti et al. [5].*

(OR 3–6) is present for promiscuous sexual behavior, the presence of an STD/STI and mental illness including depression or PTSD. The strongest association (OR greater than 7) is present for substance abuse and suicidal ideation or attempt secondary to a diagnosis of mental illness like depression or PTSD. Notably, individuals that have a pre-existing diagnosis of PTSD possess twice the odds of coronary artery calcification, contributing to poor cardiovascular health and complications of chronic disease. In general, an OR for maladaptive, high-risk behavior and morbidities increased as ACE scores increased to 4 or more. This affirms that a strong dose-response relationship exists pertaining to the number of ACEs encountered and the likelihood that health-harming behavior contributes to premature death in individuals diagnosed as having a chronic disease [7].

Aside from studies that assess for a direct correlation among instances of ACE and the development of chronic disease, incidences of international health detriments like food insecurity, armed conflict and displacement are higher in populations that admit to one or more ACEs. In the United States, 19.5% of households with children reported food insecurity [7]. In comparison, the Central African Republic comprised of the countries: Burundi, Comoros, Democratic Republic of Congo, Eritrea, Libya, Papua New Guinea, Somalia, South Sudan and Syria, reported food insecurity in 46% of households, secondary to famine [7]. Individuals that encountered 4 or more ACEs were five times more likely to encounter food insecurity in their household versus individuals that denied encountering an ACE [8]. Also, individuals that endorse 4 or more ACEs in addition to depression are associated to an approximate 30-fold increase in food insecurity. This illustrates that ACEs are an important predictor for food insecurity, regardless of the presence or absence of depression. Displacement, a common consequence of armed conflict and violence, is an international concern. Internationally, more than 1 in 10 children are affected by armed conflict. The SABE-Columbia survey, comprised of 23,694 Columbian respondents, 60 years and older, illustrates that displacement throughout one's childhood correlates with at least one chronic illness

**173**

*The Relationship of Adulthood Chronic Disease and Adverse Childhood Experiences (ACEs)…*

in approximately 68% of respondents [9]. A 2018 study surveying approximately 8000 children that encountered armed conflict or displacement exposed significant prevalence of PTSD (47%), depression (43%) and anxiety (27%) [10]. Several studies illustrate a predisposition and an increased risk of ill-health into adulthood as a result of an inappropriate activation of biological and behavioral mechanisms commonly identified in conditions like PTSD and the aforementioned mood disorders. Therefore, it is fundamental to recognize at-risk patient populations in regard to their exposure to international health detriments to mitigate their high risk of

ACE exposure results in a higher likelihood of developing chronic disease as an adult because of proposed mechanisms that alter an individual's development. This is resultant of recurrent physiologic and biomolecular damage, termed allostatic load. A proposed mechanism pertaining to allostatic load, accepted by the ACE study, is the Biological Embedding of Childhood Adversity Model. This model states that as stress accumulates from abuse, maltreatment or abandonment, a threshold is attained [11]. Attainment of this threshold promotes pro-inflammatory cellular predispositions including a disproportionate cytokine response to the posed challenge that desensitizes the inhibition of hormone signals. Studies suggest that inflammation is the fundamental mediator that translates an adolescent's altered psychosocial influences into biological predisposition for chronic disease. Adults that incurred adverse childhood experiences encountered an elevation in inflammation biomarkers, exacerbated by concurrent mood disorders like depression at the time of assessment. The lack of hormone inhibition and resultant hormonal deregulation stimulates impaired self-regulation in an individual that is already likely to possess genetic predisposition to develop adulthood chronic disease. The Biological Embedding of Childhood Adversity Model explains the alteration of an individual's neural, endocrine, immune, metabolic axes through recurrent negative stressors in the stages of life that are susceptible to such insults. These changes mediate one's cognition and emotional

wellbeing as an adult that pose complications in and of itself (**Figure 2**).

The brain and neural development in the first 2 years of life is crucial. The brain acquires 80–90% of gray and white matter throughout this time prior to adulthood advancement [12]. Aside from possible changes in the acquisition of gray and white matter, normal neurodevelopment of the brain enables environmental alterations to essentially inactivate neural synapses. This is referred to as "pruning." This illustrates the susceptibility that the young developing brain has regarding adverse experiences. ACEs are linked to pervasive and calculable changes in the structure and the function of the brain. Functional MRI has illustrated the structural and functional implications of ACE-mediated risk on psychopathologies including maladaptive adulthood behavior like substance use/abuse as depicted by changes in reward-related cognition including the prefrontal complex and mesolimbic systems. Brain anatomy including the prefrontal cortex, critical in regard to higher-level cognition, is diminished in individual's that experience ACEs as seen in functional MRI studies [12]. Additionally, the limbic system, i.e. the hippocampus and the amygdala, are instrumental in an individual's ability to recall, regulate emotion and learn. This is diminished as a result of adverse experiences, since the limbic system is deemed "stress sensitive" because of the overabundance of glucocorticoid receptors. The neurotoxicity hypothesis implies that early elevation in glucocorticoids in the anatomical regions of the brain that includes the pre-frontal cortex and limbic system, hinders the development of neurons through oxidative stress subsequent to

*DOI: http://dx.doi.org/10.5772/intechopen.93520*

chronic disease development.

**5. Proposed mechanisms**

*The Relationship of Adulthood Chronic Disease and Adverse Childhood Experiences (ACEs)… DOI: http://dx.doi.org/10.5772/intechopen.93520*

in approximately 68% of respondents [9]. A 2018 study surveying approximately 8000 children that encountered armed conflict or displacement exposed significant prevalence of PTSD (47%), depression (43%) and anxiety (27%) [10]. Several studies illustrate a predisposition and an increased risk of ill-health into adulthood as a result of an inappropriate activation of biological and behavioral mechanisms commonly identified in conditions like PTSD and the aforementioned mood disorders. Therefore, it is fundamental to recognize at-risk patient populations in regard to their exposure to international health detriments to mitigate their high risk of chronic disease development.

## **5. Proposed mechanisms**

*Contemporary Developments and Perspectives in International Health Security - Volume 1*

(OR 3–6) is present for promiscuous sexual behavior, the presence of an STD/STI and mental illness including depression or PTSD. The strongest association (OR greater than 7) is present for substance abuse and suicidal ideation or attempt secondary to a diagnosis of mental illness like depression or PTSD. Notably, individuals that have a pre-existing diagnosis of PTSD possess twice the odds of coronary artery calcification, contributing to poor cardiovascular health and complications of chronic disease. In general, an OR for maladaptive, high-risk behavior and morbidities increased as ACE scores increased to 4 or more. This affirms that a strong dose-response relationship exists pertaining to the number of ACEs encountered and the likelihood that health-harming behavior contributes to premature death in

Aside from studies that assess for a direct correlation among instances of ACE and the development of chronic disease, incidences of international health detriments like food insecurity, armed conflict and displacement are higher in populations that admit to one or more ACEs. In the United States, 19.5% of households with children reported food insecurity [7]. In comparison, the Central African Republic comprised of the countries: Burundi, Comoros, Democratic Republic of Congo, Eritrea, Libya, Papua New Guinea, Somalia, South Sudan and Syria, reported food insecurity in 46% of households, secondary to famine [7]. Individuals that encountered 4 or more ACEs were five times more likely to encounter food insecurity in their household versus individuals that denied encountering an ACE [8]. Also, individuals that endorse 4 or more ACEs in addition to depression are associated to an approximate 30-fold increase in food insecurity. This illustrates that ACEs are an important predictor for food insecurity, regardless of the presence or absence of depression. Displacement, a common consequence of armed conflict and violence, is an international concern. Internationally, more than 1 in 10 children are affected by armed conflict. The SABE-Columbia survey, comprised of 23,694 Columbian respondents, 60 years and older, illustrates that displacement throughout one's childhood correlates with at least one chronic illness

individuals diagnosed as having a chronic disease [7].

*ACEs effects on health and well-being as adapted from Felitti et al. [5].*

**172**

**Figure 1.**

ACE exposure results in a higher likelihood of developing chronic disease as an adult because of proposed mechanisms that alter an individual's development. This is resultant of recurrent physiologic and biomolecular damage, termed allostatic load. A proposed mechanism pertaining to allostatic load, accepted by the ACE study, is the Biological Embedding of Childhood Adversity Model. This model states that as stress accumulates from abuse, maltreatment or abandonment, a threshold is attained [11]. Attainment of this threshold promotes pro-inflammatory cellular predispositions including a disproportionate cytokine response to the posed challenge that desensitizes the inhibition of hormone signals. Studies suggest that inflammation is the fundamental mediator that translates an adolescent's altered psychosocial influences into biological predisposition for chronic disease. Adults that incurred adverse childhood experiences encountered an elevation in inflammation biomarkers, exacerbated by concurrent mood disorders like depression at the time of assessment. The lack of hormone inhibition and resultant hormonal deregulation stimulates impaired self-regulation in an individual that is already likely to possess genetic predisposition to develop adulthood chronic disease. The Biological Embedding of Childhood Adversity Model explains the alteration of an individual's neural, endocrine, immune, metabolic axes through recurrent negative stressors in the stages of life that are susceptible to such insults. These changes mediate one's cognition and emotional wellbeing as an adult that pose complications in and of itself (**Figure 2**).

The brain and neural development in the first 2 years of life is crucial. The brain acquires 80–90% of gray and white matter throughout this time prior to adulthood advancement [12]. Aside from possible changes in the acquisition of gray and white matter, normal neurodevelopment of the brain enables environmental alterations to essentially inactivate neural synapses. This is referred to as "pruning." This illustrates the susceptibility that the young developing brain has regarding adverse experiences. ACEs are linked to pervasive and calculable changes in the structure and the function of the brain. Functional MRI has illustrated the structural and functional implications of ACE-mediated risk on psychopathologies including maladaptive adulthood behavior like substance use/abuse as depicted by changes in reward-related cognition including the prefrontal complex and mesolimbic systems. Brain anatomy including the prefrontal cortex, critical in regard to higher-level cognition, is diminished in individual's that experience ACEs as seen in functional MRI studies [12]. Additionally, the limbic system, i.e. the hippocampus and the amygdala, are instrumental in an individual's ability to recall, regulate emotion and learn. This is diminished as a result of adverse experiences, since the limbic system is deemed "stress sensitive" because of the overabundance of glucocorticoid receptors. The neurotoxicity hypothesis implies that early elevation in glucocorticoids in the anatomical regions of the brain that includes the pre-frontal cortex and limbic system, hinders the development of neurons through oxidative stress subsequent to

#### *Contemporary Developments and Perspectives in International Health Security - Volume 1*

**Figure 2.**

*The biological embedding of childhood adversity model resultant of early exposure psychosocial stressors as adapted from Berens [12].*

elevated cortisol. An elevation in cortisol and the subsequent elevation in inflammatory cytokines and excitatory amino acids like glutamate potentiate this hindrance.

The Hypothalamic-Pituitary-Adrenal (HPA) axis and the autonomic axes, involving the sympathetic and parasympathetic nervous system, are fundamental in an individual's response to stressors through release of molecular mediators like corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and glucocorticoids. An individual's exposure to ACEs promotes adulthood HPA deregulation through an exaggerated hyper- or hypoactive response secondary to an increased allostatic load. Increased allostatic load promotes physiologic and biomolecular changes related to the development of chronic disease [13]. Sympathetic activation by the brainstem induces adrenal-medullary epinephrine/norepinephrine output to organs like the heart, liver, pancreas. Conversely, parasympathetic activation significantly mitigates this response to stressors. Autonomic dysregulation and imbalance implies deleterious stress-sensitive alterations by an increased allostatic load which has the propensity to predispose individuals to chronic disease through a predictable response by stress-sensitive organ to the excess hormones. This results in cardiovascular and metabolic derangements. Detrimental metabolic changes include severe obesity, dyslipidemia and diabetes. These changes transpire through the dysregulation of catabolism and anabolism. The balance between catabolism and anabolism is achieved through the regulation of hormones, i.e. cortisol, glucagon, epinephrine/norepinephrine and insulin. Exposure to ACEs stimulates inflammation and the hypersecretion of cortisol, stimulating catabolism. This results in resistance of peripheral tissues to insulin and an ensuing increase in blood glucose levels.

The response to internal and external stimuli is mediated by innate and adaptive immune systems. Regularly, this response results in an appropriate elevation in inflammatory mediators that include tumor necrosis factor, nuclear factors and interleukins. Conversely, chronic elevation in inflammation results in a prevailing immunosuppressed state secondary to cytotoxic, oxidative stress. Studies affirm

**175**

*The Relationship of Adulthood Chronic Disease and Adverse Childhood Experiences (ACEs)…*

that this state of immunosuppression, portrayed as a "pro-inflammatory phenotype," potentiates the anti-inflammatory action of cortisol through the resistance of downstream receptors [14]. The pro-inflammatory state that promotes immunosuppression has implications on predisposing individuals to chronic ailments related to the development of oncologic disease through the inability of the immune system to impede oncogenic viruses. This increases an individual's likelihood that a precursory, precancerous condition becomes malignant. Additionally, the role of a pro-inflammatory state is apparent in cardiovascular and metabolic diseases like

**6. Examples of inflammation and allosteric load in chronic disease**

tion considerably worsens an individual's cardiovascular condition.

opposed to anti-inflammatory state in the presence of mediators.

Chronic inflammation is a hallmark of cardiovascular disease. Initially, cardiovascular disease, specifically coronary artery disease, was deemed a cholesterol storage disorder described by the accumulation of cholesterol in the walls of the arteries. Nonetheless, studies have shown that the presence of an elevated serum inflammatory marker is a significant predictor of cardiovascular risk irrespective of an individual's lipid profile. Also, elevated inflammatory markers correlate to a recurrent risk of complications including myocardial infarction, peripheral artery disease and stroke in individuals diagnosed as having acute coronary syndrome. Common cardiovascular risk factors like hypertension, hyperglycemia and tobacco use promote a pro-inflammatory phenotype through vascular injury. The propagation of the pro-inflammatory state through recruitment of inflammatory mediators transpires through transformation of lipoproteins to fatty streaks. The accumulation of coagulation factors promotes the propagation of inflammation and destabilizes the plaque. This state promotes cardiac complications like myocardial infarction, peripheral artery disease and stroke. This cascade of chronic inflamma-

Several studies have illustrated the importance of inflammation in pathophysiology of type 1 (T1D) and type 2 diabetes (T2D). The pathophysiology of T1D is described as an autoimmune phenomenon caused by the inflammation of beta cells of the pancreas, referred to as insulitis. The predominance of inflammation is mediated through inflammatory mediators that increase in metabolic stress. A peri-islet inflammation cascade is triggered that subsequently destroys pancreatic beta cells causing type 1 diabetes. The pathophysiology of T2D is described as insulin resistance balanced by the hypersecretion of insulin by pancreatic beta cells. Unfortunately, throughout the disease process progression, the beta cells are unable to attain a balance, causing a pathologic state to be present. Inflammation of the pancreatic beta cells increases the number of dysfunctional beta cells. This is predominantly achieved through the activation of a pro-inflammatory state as

A 2000 study by A. A. Alonzo examined the addition of adverse experiences to an initially identified trauma as an example of the negative implications allosteric load has on chronic illness. Alonzo defines the term "cumulative adversity" as the propagation of physiologic changes like a pro-inflammatory state, more pronounced in increasing instances of adversity, through maladaptive behavior and an incapacity to cope. Additionally, increasing instances of adversities or ACEs predispose individuals to the triggering of PTSD. The prevalence of PTSD and exposure to trauma throughout one's childhood into adulthood is 40–75%, often occurring with other comorbid conditions [16]. Therefore, it is imperative to identify the role of ACEs and PTSD in the development of adulthood chronic illness in addition to the role chronic illness has itself as a traumatogenic burden that has the ability

*DOI: http://dx.doi.org/10.5772/intechopen.93520*

coronary artery disease and diabetes [15].

*The Relationship of Adulthood Chronic Disease and Adverse Childhood Experiences (ACEs)… DOI: http://dx.doi.org/10.5772/intechopen.93520*

that this state of immunosuppression, portrayed as a "pro-inflammatory phenotype," potentiates the anti-inflammatory action of cortisol through the resistance of downstream receptors [14]. The pro-inflammatory state that promotes immunosuppression has implications on predisposing individuals to chronic ailments related to the development of oncologic disease through the inability of the immune system to impede oncogenic viruses. This increases an individual's likelihood that a precursory, precancerous condition becomes malignant. Additionally, the role of a pro-inflammatory state is apparent in cardiovascular and metabolic diseases like coronary artery disease and diabetes [15].

#### **6. Examples of inflammation and allosteric load in chronic disease**

Chronic inflammation is a hallmark of cardiovascular disease. Initially, cardiovascular disease, specifically coronary artery disease, was deemed a cholesterol storage disorder described by the accumulation of cholesterol in the walls of the arteries. Nonetheless, studies have shown that the presence of an elevated serum inflammatory marker is a significant predictor of cardiovascular risk irrespective of an individual's lipid profile. Also, elevated inflammatory markers correlate to a recurrent risk of complications including myocardial infarction, peripheral artery disease and stroke in individuals diagnosed as having acute coronary syndrome. Common cardiovascular risk factors like hypertension, hyperglycemia and tobacco use promote a pro-inflammatory phenotype through vascular injury. The propagation of the pro-inflammatory state through recruitment of inflammatory mediators transpires through transformation of lipoproteins to fatty streaks. The accumulation of coagulation factors promotes the propagation of inflammation and destabilizes the plaque. This state promotes cardiac complications like myocardial infarction, peripheral artery disease and stroke. This cascade of chronic inflammation considerably worsens an individual's cardiovascular condition.

Several studies have illustrated the importance of inflammation in pathophysiology of type 1 (T1D) and type 2 diabetes (T2D). The pathophysiology of T1D is described as an autoimmune phenomenon caused by the inflammation of beta cells of the pancreas, referred to as insulitis. The predominance of inflammation is mediated through inflammatory mediators that increase in metabolic stress. A peri-islet inflammation cascade is triggered that subsequently destroys pancreatic beta cells causing type 1 diabetes. The pathophysiology of T2D is described as insulin resistance balanced by the hypersecretion of insulin by pancreatic beta cells. Unfortunately, throughout the disease process progression, the beta cells are unable to attain a balance, causing a pathologic state to be present. Inflammation of the pancreatic beta cells increases the number of dysfunctional beta cells. This is predominantly achieved through the activation of a pro-inflammatory state as opposed to anti-inflammatory state in the presence of mediators.

A 2000 study by A. A. Alonzo examined the addition of adverse experiences to an initially identified trauma as an example of the negative implications allosteric load has on chronic illness. Alonzo defines the term "cumulative adversity" as the propagation of physiologic changes like a pro-inflammatory state, more pronounced in increasing instances of adversity, through maladaptive behavior and an incapacity to cope. Additionally, increasing instances of adversities or ACEs predispose individuals to the triggering of PTSD. The prevalence of PTSD and exposure to trauma throughout one's childhood into adulthood is 40–75%, often occurring with other comorbid conditions [16]. Therefore, it is imperative to identify the role of ACEs and PTSD in the development of adulthood chronic illness in addition to the role chronic illness has itself as a traumatogenic burden that has the ability

*Contemporary Developments and Perspectives in International Health Security - Volume 1*

elevated cortisol. An elevation in cortisol and the subsequent elevation in inflammatory cytokines and excitatory amino acids like glutamate potentiate this hindrance. The Hypothalamic-Pituitary-Adrenal (HPA) axis and the autonomic axes, involving the sympathetic and parasympathetic nervous system, are fundamental in an individual's response to stressors through release of molecular mediators like corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and glucocorticoids. An individual's exposure to ACEs promotes adulthood HPA deregulation through an exaggerated hyper- or hypoactive response secondary to an increased allostatic load. Increased allostatic load promotes physiologic and biomolecular changes related to the development of chronic disease [13]. Sympathetic activation by the brainstem induces adrenal-medullary epinephrine/norepinephrine output to organs like the heart, liver, pancreas. Conversely, parasympathetic activation significantly mitigates this response to stressors. Autonomic dysregulation and imbalance implies deleterious stress-sensitive alterations by an increased allostatic load which has the propensity to predispose individuals to chronic disease through a predictable response by stress-sensitive organ to the excess hormones. This results in cardiovascular and metabolic derangements. Detrimental metabolic changes include severe obesity, dyslipidemia and diabetes. These changes transpire through the dysregulation of catabolism and anabolism. The balance between catabolism and anabolism is achieved through the regulation of hormones, i.e. cortisol, glucagon, epinephrine/norepinephrine and insulin. Exposure to ACEs stimulates inflammation and the hypersecretion of cortisol, stimulating catabolism. This results in resistance of peripheral tissues to insulin and an ensuing increase in blood glucose levels. The response to internal and external stimuli is mediated by innate and adaptive immune systems. Regularly, this response results in an appropriate elevation in inflammatory mediators that include tumor necrosis factor, nuclear factors and interleukins. Conversely, chronic elevation in inflammation results in a prevailing immunosuppressed state secondary to cytotoxic, oxidative stress. Studies affirm

*The biological embedding of childhood adversity model resultant of early exposure psychosocial stressors as* 

**174**

**Figure 2.**

*adapted from Berens [12].*

to accumulate because of disease trajectory, intrusive or invasive procedures and administrative annoyances.
