**3.3 Role of breathing in brain cooling**

The arteriovenous pressure difference described above can lead to the potential role of breathing on the dynamics of CSF flow within the extensive paravascular system. The close relationship of the paranasal sinuses with the basal cisterns provides an excellent radiation chamber that can help in buffering the thermal environment of the brain through continuous evaporation of the mucosa-lined sinus surfaces in contact with the external atmosphere, hence the hypothesis of breathing playing an important role in the cooling of the brain and possibly the clearance of molecules within the paravascular system.
