Meet the editor

Xianquan Zhan received his MD and PhD in Preventive Medicine from West China University of Medical Sciences in 1989– 1999. He received his post-doctoral training in Oncology and Cancer Proteomics at Central South University and University of Tennessee Health Science Center (UTHSC). He worked at UTHSC and Cleveland Clinic from 2001 to 2012, and achieved the rank of Associate Professor at UTHSC. Currently, he is a full

professor at Central South University and Shandong First Medical University, and an advisor for MS/PhD graduate students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine, fellow of EPMA, a European EPMA National Representative, full member of the American Society of Clinical Oncology (ASCO), member of the American Association for the Advancement of Science (AAAS), editor-in-chief of *International Journal of Chronic Diseases & Therapy*, associate editors of *EPMA Journal* and *BMC Medical Genomics*, and guest editor of *Frontiers in Endocrinology* and *Mass Spectrometry Reviews*. Dr. Zhan has published more than 100 articles, seventeen book chapters, three books, and two US patents in the field of clinical proteomics and biomarkers.

Contents

*by Xianquan Zhan*

for Identification

Mass Spectrometry

*and Hartmut Schlüter*

Introductory Chapter: Proteoforms

**Preface XI**

**Chapter 1 1**

**Chapter 2 7**

**Chapter 3 27**

**Chapter 4 47**

**Chapter 5 61**

Proteoforms: General Concepts and Methodological Process

Preparing Proteoforms of Therapeutic Proteins for Top-Down

*by Jucélia da Silva Araújo and Olga Lima Tavares Machado*

*by Siti Nurul Hidayah, Manasi Gaikwad, Laura Heikaus* 

Prolactin Proteoform Pattern Changed in Human Pituitary

Proteoforms in Acute Leukemia: Evaluation of Age- and

*by Fieke W. Hoff, Anneke D. van Dijk and Steven M. Kornblau*

Adenoma Relative to Control Pituitary Tissues

*by Xianquan Zhan and Shehua Qian*

Disease-Specific Proteoform Patterns
