*6.2.3 Surface topography*

It is stated that surface roughness may enhance adhesion between cell and extracellular matrix. At the same time, too rough surface of the scaffold may exhaust the cell adhesion capability. On the other side, if the scaffold material is too sharp, the cells may get damaged. However, choosing a smooth surfaced scaffold material may require consideration of further modification or coating, as this feature does not facilitate cell adhesion.
