**3. Precipitation using supercritical fluids**

In order to design a supercritical precipitation process several aspects must be taken into account. First, the solubility of the solute to micronize in supercritical fluids must be known in order to choose RESS or SAS process. Then, a solvent able to turn the solute soluble must be chosen, and elucidate the ternary phase equilibrium diagram solvent-solute-CO2 or the binary phase equilibrium solvent-CO2 when the solubility of the solute into CO2 is neglected. Volumetric expansion curves and volumetric equilibrium data are required. Not only the thermodynamic data but also the hydrodynamic of the process should be investigated.
