**Author details**

Sonia Aroui\* and Abderraouf Kenani Unité de Recherche UR 12ES08 "Signalisation Cellulaire et Pathologies", Faculté de Médecine de Monastir, Monastir, Tunisie

\*Address all correspondence to: sonia\_aroui2002@yahoo.fr

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Cell-Penetrating Peptides: A Challenge for Drug Delivery DOI: http://dx.doi.org/10.5772/intechopen.91684*

> [10] Wu X, Gehring W. Cellular uptake of the *Antennapedia homeodomain* polypeptide by macropinocytosis. Biochemical and Biophysical Research

[11] Ziegler A, Nervi P, Durrenberger M, Seelig J. The cationic cell-penetrating peptide CPP TAT derived from the

Communications. 2013;**13**:1-1

HIV-1 protein tat is rapidly

Optical, biophysical and

2005;**44**:138-148

1988;**55**:1179-1188

1997;**272**:16010-16017

2004;**6**:189-196

2000;**469**:179-185

peptides: From technology to physiology. Nature Cell Biology.

[15] Fajloun Z, Kharrat R, Chen L, Lecomte C, Di Luccio E, Bichet D, et al. Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca(2+) release channel/ ryanodine receptors. FEBS Letters.

[16] Esteve E, Smida-Rezgui S, Sarkozi S, Szegedi C, Regaya I, Chen L, et al. Critical amino acid residues determine the binding affinity

and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. The Journal of Biological Chemistry.

2003;**278**:37822-37831

transported into living fibroblasts:

metabolic evidence. Biochemistry.

[12] Green M, Loewenstein PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein. Cell.

[13] Vives E, Brodin P, Lebleu B. A truncated HIV-1 tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. The Journal of Biological Chemistry.

[14] Joliot A, Prochiantz A. Transduction

[1] El-Sayed A, Futaki S, Harashima H. The AAPS Journal. 2009;**11**:13-22

**References**

[2] Moon JI, Han MJ, Yu SH, Lee EH, Kim SM, Han K, et al. Enhanced delivery of protein fused to cell penetrating peptides to mammalian cells. BMB Reports. May 2019;**52**(5):324-329

[3] Aroui S, Ram N, Appaix F, Ronjat M, Kenani A, Pirollet F, et al. Maurocalcine as a non toxic drug carrier overcomes doxorubicin resistance in the cancer cell line MDA-MB 231. Pharmaceutical

Research. 2008;**10**:9782-9801

[4] Aroui S, Brahim S, De Waard M, Bréard J, Kenani A. Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231. Cancer Letters. 2009;**285**:28-38

[5] Lönn P, Dowdy SF. Cationic PTD/ CPP-mediated macromolecular delivery: Charging into the cell. Expert Opinion on Drug Delivery. 2015;**12**(10):1627-1636

[6] Schroeder JA, Bitler BG. Anti-cancer therapies that utilize cell penetrating peptides. Recent Patents on Anti-Cancer

[7] Jarver P, Langel U. Cell-penetrating

[8] Lehto T, Kurrikoff K, Langel U. Cellpenetrating peptides for the delivery of nucleic acids. Expert Opinion on Drug

Drug Discovery. 2010;**5**:1-10

peptides-a brief introduction. Biochimica et Biophysica Acta.

2006;**1758**:260-263

Delivery. 2012;**9**:823-836

2008;**29**:24274-24284

[9] Ram N, Aroui S, Jaumain E, Bichraoui H, Mabrouk K, Ronjat M, et al. Direct peptide interaction with surface glycosaminoglycans contributes to the cell penetration of maurocalcine. The Journal of Biological Chemistry.

*Cell-Penetrating Peptides: A Challenge for Drug Delivery DOI: http://dx.doi.org/10.5772/intechopen.91684*
