**5. Conclusions**

This chapter presented an innovative family of nanocomposite magnetic biomaterials and their biomedical applications. Mixing magnetic nanoparticles with traditional biomaterials, e.g., polymer or ceramics, or chemically doping them allows the manufacturing of a magnetic-responsive biomaterial with multifunctional properties. The so-called magnetic scaffolds have been studied for their ability to transduce an external magnetic signal into mechanical and biological outcome, thus proving to be a powerful platform for cell and tissue stimulation [1–4]. Exploiting the ability of the MNPs embedded in the biomaterial to dissipate power when exposed to a radio-frequency magnetic field makes MagS a valid candidate to perform local hyperthermia treatment on residual cancer cells. In this chapter the physical properties and the magnetic susceptibility of these novel composite nanosystems are investigated. Then an in silico model to study the feasibility of employing MagS in the treatment of bone cancers, such as osteosarcomas and fibrosarcomas, is presented [14]. The results indicate that further research on the nanomaterial is required to develop an effective and tailored magnetic scaffold. Finally, the potential of MagS to serve as an in vivo attraction site to enhance the magnetic drug delivery of growth factors is faced. To predict the final concentration pattern, a mathematical model which relates the nonlinear magnetic problem and the mass transport issue is presented. Furthermore, the link between these two aspects and the biological influence on cellular migration is challenged [13]. The results indicate that MagS are able to attract MNPs and exert an indirect action on MSCs in a way dependent on the geometrical and material properties.
